Patents by Inventor Xiaozhang Zheng

Xiaozhang Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230365562
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 31, 2023
    Publication date: November 16, 2023
    Inventors: Nello MAINOLFI, Chris DE SAVI, Matthew M. WEISS, Xiao ZHU, Xiaozhang ZHENG, Bruce C. FOLLOWS
  • BICYCLIC [4,6,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20230357216
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formulae I or Formula II: where R, L, X1, X2, X3, X4, X5, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: May 12, 2023
    Publication date: November 9, 2023
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Aleksandra Rudnitskaya, David R. Lancia, JR.
  • IRAK degraders and uses thereof
    Patent number: 11807636
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: November 7, 2023
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20230346753
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: December 2, 2022
    Publication date: November 2, 2023
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230303526
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 28, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
  • 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
    Patent number: 11730721
    Abstract: The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: August 22, 2023
    Assignee: Valo Health, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Mary-Margaret Zablocki
  • DEUTERATED IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230250110
    Abstract: The present invention provides deuterium-enriched compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 3, 2021
    Publication date: August 10, 2023
    Inventor: Xiaozhang ZHENG
  • ISOINDOLINES AS HDAC INHIBITORS
    Publication number: 20230242512
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs), having the formula: wherein Z, X1, X2, Y1, Y2, Y3, L, Z, and R are described herein.
    Type: Application
    Filed: November 9, 2022
    Publication date: August 3, 2023
    Inventors: Xiaozhang Zheng, Matthew W. Martin, Pui Yee Ng, Jennifer R. Thomason, Bingsong Han, Aleksandra Rudnitskaya, David R. Lancia, JR.
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230234953
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 20, 2022
    Publication date: July 27, 2023
    Inventors: Matthew M. WEISS, Xiaozhang Zheng, Xiao Zhu
  • Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
    Patent number: 11702412
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formulae I or Formula II: where R, L, X1, X2, X3, X4, X5, Y1, Y2, Y3, and Y4 are described herein.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: July 18, 2023
    Assignee: Valo Health, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Aleksandra Rudnitskaya, David R. Lancia, Jr.
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230219945
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 13, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING, Xiao ZHU
  • Crystalline forms of IRAK degraders
    Patent number: 11685750
    Abstract: The present disclosure relates generally to various forms, salts and compositions of compounds useful for the modulation of one or more interleukin-1 receptor-associated kinases (“IRAK”) via ubiquitination and/or degradation and uses of the same in the treatment various diseases.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: June 27, 2023
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Xiaozhang Zheng, Don Corson
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230190940
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 9, 2020
    Publication date: June 22, 2023
    Inventors: Yi ZHANG, Xiaozhang ZHENG, Xiao ZHU
  • Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
    Patent number: 11649242
    Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: May 16, 2023
    Assignee: FORMA THERAPEUTICS, INC.
    Inventors: Anna Ericsson, Neal Green, Gary Gustafson, Bingsong Han, David R. Lancia, Jr., Lorna Mitchell, David Richard, Tatiana Shelekhin, Chase C. Smith, Zhongguo Wang, Xiaozhang Zheng
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230132715
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 17, 2020
    Publication date: May 4, 2023
    Inventors: Nan JI, Michael D. SINTCHAK, Yi ZHANG, Xiaozhang ZHENG
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230122219
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 3, 2021
    Publication date: April 20, 2023
    Inventors: Matthew M. WEISS, Xiaozhang ZHENG
  • CDK2 DEGRADERS AND USES THEREOF
    Publication number: 20230110180
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 6, 2022
    Publication date: April 13, 2023
    Inventors: Xiaozhang ZHENG, Yi ZHANG, Rober AVERSA, Xiao ZHU, Philip COLLIER
  • PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
    Publication number: 20230110003
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: September 9, 2022
    Publication date: April 13, 2023
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Bingsong Han, Judith D. Kuntz, Jian Lin, Dominic J. Reynolds, Chase C. Smith, Zhongguo Wang, Xiaozhang Zheng
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230096599
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 9, 2021
    Publication date: March 30, 2023
    Inventors: Xiaozhang ZHENG, Xiao ZHU
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230101353
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 30, 2021
    Publication date: March 30, 2023
    Inventors: Nello Mainolfi, Nan Ji, Matthew M. Weiss, Xiaozhang Zheng, Yi Zhang, Paul R. Fleming, Xiao Zhu