Patents by Inventor Xiaozhong Qian

Xiaozhong Qian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING TUMOR
    Publication number: 20220195046
    Abstract: The disclosure provides a method for treating a subject afflicted with a tumor comprising administering to the subject a therapeutically effective amount of an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or anti-gen-binding portion thereof, wherein the subject is identified as having a high inflammatory gene signature score and a tumor that has a high tumor mutation burden (TMB) status. In some embodiments, the high inflammatory gene signature score is determined by measuring the expression of a panel of inflammatory genes in a tumor sample obtained from the subject, wherein the inflammatory gene panel comprises CD274 (PD-L1), CD8A, LAG3, and STAT1.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 23, 2022
    Applicant: Bristol-Myers Squibb Company
    Inventors: Ming LEI, Nathan O. SIEMERS, Dimple PANDYA, Han CHANG, Teresa K. SANCHEZ, Christopher T. HARBISON, Peter M. SZABO, Zachary S. BOYD, Xiaozhong QIAN, Samy Abdel SACI, Tina C. YOUNG, Sujaya SRINIVASAN, Megan M. WIND-ROTOLO, Jasmine RIZZO, Donald G. JACKSON, Alice M. WALSH
  • ROFLUMILAST COMPOSITIONS FOR THE TREATMENT OF COPD
    Publication number: 20150164916
    Abstract: The present invention relates to pharmaceutical compositions comprising roflumilast in combination with a corticosteroid and/or a leukotriene receptor antagonist. The invention also relates to the use of such compositions for the treatment of Chronic Obstructive Pulmonary Disorder (COPD).
    Type: Application
    Filed: February 25, 2015
    Publication date: June 18, 2015
    Inventors: Jose Freire, Xiaozhong Qian, Colin Scott
  • Novel proteins and nucleic acids encoding same
    Publication number: 20060084054
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 4, 2003
    Publication date: April 20, 2006
    Inventors: John Alsobrook, David Anderson, Jason Baumgartner, Constance Berghs, Ferenc Boldog, Catherine Burgess, Stacie Casman, Elina Catterton, Mohanraj Dhanabal, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, William Grosse, Erik Gunther, Xiaojia Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Nikolai Khramtsov, William LaRochelle, Li Li, Hongping Liang, Kenneth Low, John MacDougall, Timothy Maclachlan, Uriel Malyankar, Kelly McQueeney, Amanda Mezick, Charles Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, John Peyman, Xiaozhong Qian, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Sujatha Sukumaran, Edward Szekeres, Corine Vernet, Edward Voss, Adam Wolenc, Mei Zhong, Haihong Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040029226
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 6, 2003
    Publication date: February 12, 2004
    Inventors: John Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, Ammitabha Chaudhuri, Steven D. Colman, Shlomit R. Edinger, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia Sasha Guo, Ramesh Kekuda, Li Li, Timothy Z. MacLachlan, Uriel M. Malyankar, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, John A. Peyman, Xiaozhong Qian, Luca Rastelli, Daniel K. Rieger, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Sujatha Sukumaran, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong