Patents by Inventor Xiaozhuo Chen
Xiaozhuo Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210317068Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: ApplicationFiled: June 16, 2021Publication date: October 14, 2021Inventors: XIAOZHUO CHEN, STEPHEN BERGMEIER
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Patent number: 11072576Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: GrantFiled: July 25, 2019Date of Patent: July 27, 2021Assignee: OHIO UNIVERSITYInventors: Xiaozhuo Chen, Stephen Bergmeier
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Patent number: 10774079Abstract: Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.Type: GrantFiled: August 8, 2019Date of Patent: September 15, 2020Assignee: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.Inventors: Ying Shi, Qingzhi Gao, Xiaozhuo Chen, Yi Mi, Yaran Zhang, Hanyu Yang, Yujie Chen, Chunlei Liu, Guorui Mi, Yuxiu Ma, Dongmin Shen, Yang Guo, Linjing Fan
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Patent number: 10647654Abstract: Compounds that inhibit or reduce glucose transport and methods of using the compounds to treat cancer are provided herein.Type: GrantFiled: June 23, 2017Date of Patent: May 12, 2020Assignee: Ohio UniversityInventors: Stephen Bergmeier, Xiaozhuo Chen
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Patent number: 10550073Abstract: The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R1, Z and Q are as described in the description.Type: GrantFiled: September 30, 2016Date of Patent: February 4, 2020Assignee: CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.Inventors: Ying Shi, Yi Mi, Hanyu Yang, Xuliang Wang, Denghuang Gong, Min Bai, Xiaozhuo Chen, Yujie Chen, Xuejiao Zhang, Yuxiu Ma, Qingzhi Gao
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Publication number: 20190367500Abstract: Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.Type: ApplicationFiled: August 8, 2019Publication date: December 5, 2019Inventors: Ying SHI, Qingzhi GAO, Xiaozhuo CHEN, Yi MI, Yaran ZHANG, Hanyu YANG, Yujie CHEN, Chunlei LIU, Guorui MI, Yuxiu MA, Dongmin SHEN, Yang GUO, Linjing FAN
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Publication number: 20190345094Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: ApplicationFiled: July 25, 2019Publication date: November 14, 2019Inventors: XIAOZHUO CHEN, STEPHEN BERGMEIER
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Publication number: 20190322613Abstract: Compounds that inhibit or reduce glucose transport and methods of using the compounds to treat cancer are provided herein.Type: ApplicationFiled: June 23, 2017Publication date: October 24, 2019Inventors: STEPHEN BERGMEIER, XIAOZHUO CHEN
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Patent number: 10421754Abstract: Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.Type: GrantFiled: August 11, 2015Date of Patent: September 24, 2019Assignee: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.Inventors: Ying Shi, Qingzhi Gao, Xiaozhuo Chen, Yi Mi, Yaran Zhang, Hanyu Yang, Yujie Chen, Chunlei Liu, Guorui Mi, Yuxiu Ma, Dongmin Shen, Yang Guo, Linjing Fan
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Patent number: 10385005Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: GrantFiled: June 1, 2018Date of Patent: August 20, 2019Assignee: Ohio UniversityInventors: Xiaozhuo Chen, Stephen Bergmeier
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Publication number: 20180346406Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: ApplicationFiled: June 1, 2018Publication date: December 6, 2018Inventors: XIAOZHUO CHEN, STEPHEN BERGMEIER
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Publication number: 20180312462Abstract: The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R1, Z and Q are as described in the description.Type: ApplicationFiled: September 30, 2016Publication date: November 1, 2018Inventors: Ying SHI, Yi MI, Hanyu YANG, Xuliang WANG, Denghuang GONG, Min BAI, Xiaozhuo CHEN, Yujie CHEN, Xuejiao ZHANG, Yuxiu MA, Qingzhi GAO
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Patent number: 10000443Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: GrantFiled: November 9, 2015Date of Patent: June 19, 2018Assignee: Ohio UniversityInventors: Xiaozhuo Chen, Stephen Bergmeier
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Publication number: 20170226099Abstract: Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.Type: ApplicationFiled: August 11, 2015Publication date: August 10, 2017Inventors: Ying SHI, Qingzhi GAO, Xiaozhuo CHEN, Yi MI, Yaran ZHANG, Hanyu YANG, Yujie CHEN, Chunlei LIU, Guorui MI, Yuxiu MA, Dongmin SHEN, Yang GUO, Linjing FAN
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Publication number: 20160137585Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: ApplicationFiled: November 9, 2015Publication date: May 19, 2016Applicant: OHIO UNIVERSITYInventors: XIAOZHUO CHEN, STEPHEN BERGMEIER
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Patent number: 9181162Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: GrantFiled: March 24, 2011Date of Patent: November 10, 2015Assignee: Ohio UniversityInventors: Xiaozhuo Chen, Stephen Bergmeier
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Publication number: 20120121536Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.Type: ApplicationFiled: March 24, 2011Publication date: May 17, 2012Applicant: OHIO UNIVERSITYInventors: Xiaozhuo Chen, Stephen Bergmeier
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Patent number: 7888042Abstract: Methods are provided for identifying and selecting candidate molecules that activate glucose transport through binding of the insulin receptor at a site other than the insulin binding site. The methods include analyzing the properties of one or more candidate molecules in terms of the ability to bind the insulin receptor and activate glucose transport. Optionally the methods include, competitive assays in the presence of the glucose receptor, a candidate molecule, and one or more of insulin, alpha PGG and beta PGG.Type: GrantFiled: August 31, 2006Date of Patent: February 15, 2011Assignee: Ohio UniversityInventor: Xiaozhuo Chen
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Patent number: 7687472Abstract: Methods of treating hyperglycemic, hyperlipidemic, and hyperinsulinemic disorders are provided. Compositions for treating such disorders are also provided. The compositions can include hexose and pentose variants having acid moieties and a substituent Y linked to the six position of a hexose or the five position of the pentose.Type: GrantFiled: September 23, 2005Date of Patent: March 30, 2010Assignee: Ohio UniversityInventors: Xiaozhuo Chen, Klaus Himmeldirk, Yulin Ren
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Publication number: 20090203150Abstract: Methods are provided for identifying and selecting candidate molecules that activate glucose transport through binding of the insulin receptor at a site other than the insulin binding site. The methods include analyzing the properties of one or more candidate molecules in terms of the ability to bind the insulin receptor and activate glucose transport. Optionally the methods include, competitive assays in the presence of the glucose receptor, a candidate molecule, and one or more of insulin, alpha PGG and beta PGG.Type: ApplicationFiled: August 31, 2006Publication date: August 13, 2009Applicant: OHIO UNIVERSITYInventor: Xiaozhuo Chen