Patents by Inventor Xiayang Qiu

Xiayang Qiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PCSK9 ANTAGONISTS
    Publication number: 20100068199
    Abstract: The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
    Type: Application
    Filed: September 11, 2009
    Publication date: March 18, 2010
    Inventors: Hong Liang, Yasmina Noubia Abdiche, Javier Fernando Chaparro Riggers, Bruce Charles Gomes, Julie Jia Li Hawkins, Jaume Pons, Xiayang Qiu, Pavel Strop, Yuli Wang
  • Murine IL-18 crystal structure
    Publication number: 20060177871
    Abstract: A novel murine IL-18 native crystalline structure is identified.
    Type: Application
    Filed: August 13, 2003
    Publication date: August 10, 2006
    Inventors: Cheryl Janson, Xiayang Qiu, Ward Smith
  • Crystal structure of homo sapiens adipocyte lipid binbing protein and uses thereof
    Publication number: 20040219653
    Abstract: The invention is directed generally to the structure of lipid binding proteins, particularly human lipid binding protein (aP2), a protein important in adipocyte function. The invention also relates to the use of a crystal structure of human lipid binding protein or mutants and the interaction with ligands for the design of inhibitors. Furthermore, the invention relates to the structure of ligand binding sites.
    Type: Application
    Filed: April 30, 2004
    Publication date: November 4, 2004
    Applicant: Pfizer Inc
    Inventor: Xiayang Qiu
  • Crystal structures of streptococcus undecaprenyl pyrophosphate synthase and uses thereof
    Publication number: 20040191271
    Abstract: The invention is directed generally to the structure of prenyltransferases, particularly undecaprenyl pyrophosphate synthase, an enzyme important in bacterial cell wall synthesis. The invention relates to the crystal structure of undecaprenyl pyrophosphate synthase from Streptococcus pneumoniae and its interaction with cofactors and ligands. The invention also relates to the structure of ligand and cofactor binding sites of undecaprenyl pyrophosphate synthase.
    Type: Application
    Filed: March 31, 2004
    Publication date: September 30, 2004
    Applicant: Pfizer Inc
    Inventors: Kimberly F. Fennell, Mahmoud N. Mansour, Xiayang Qiu
  • Novel fabh enzyme, compositions capable of binding to said enzyme and methods of use thereof
    Publication number: 20040181038
    Abstract: A novel E. coli FabH crystalline structure is identified. Also disclosed are methods of identifying inhibitors of these enzymes and/or active sites, and inhibitors identified by these methods.
    Type: Application
    Filed: March 17, 2004
    Publication date: September 16, 2004
    Applicant: SmithKline Beecham Corporation
    Inventors: Cheryl Ann Janson, Xiayang Qiu
  • Methods using the staphylococcus aureus glycyl tRNA synthetase crystalline structure
    Patent number: 6197495
    Abstract: A novel Staphylococcus glycyl tRNA synthetase crystalline structure is identified. Also disclosed are methods of identifying inhibitors of these synthetases and/or active sites, and inhibitors identified by these methods.
    Type: Grant
    Filed: May 10, 1998
    Date of Patent: March 6, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Xiayang Qiu, Neal Frederick Osborne, Christine Mary Richardson, Cheryl A. Janson
  • Proteases compositions capable of binding to said site, and methods of use thereof
    Patent number: 6083711
    Abstract: Novel herpes viral protease crystalline structures are identified which have an active site formed by the three amino acids Ser, His and His. Also disclosed are methods of identifying inhibitors of these proteases and/or active sites.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: July 4, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Sherin Salaheldin Abdel-Meguid, Xiayang Qiu, Ward Whitlock Smith, Jr., Cheryl Ann Janson, Susan S. Hoog, Jeffrey Culp, Christine Marie Debouck
  • Methods using the Staphylococcus aureus glycyl tRNA synthetase crystalline structure
    Patent number: 6037117
    Abstract: A novel Staphylococcus glycyl tRNA synthetase crystalline structure is identified. Also disclosed are methods of identifying inhibitors of these synthetases and/or active sites, and inhibitors identified by these methods.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: March 14, 2000
    Assignees: Smithkline Beecham Corporation, Smithkline Beecham plc
    Inventors: Xiayang Qiu, Neal Frederick Osborne, Christine Mary Richardson, Cheryl A. Janson
  • Proteases, compositions capable of binding to said site, and methods of use thereof
    Patent number: 6008033
    Abstract: Novel herpes viral protease crystalline structures are identified which have an active site formed by the three amino acids Ser, His and His. Also disclosed are methods of identifying inhibitors of these proteases and/or active sites.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: December 28, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Sherin Salaheldin Abdel-Meguid, Xiayang Qiu, Ward Whitlock Smith, Jr., Cheryl Ann Janson, Susan S. Hoog, Jeffrey Culp, Christine Marie Debouck