Patents by Inventor Xican Tang

Xican Tang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORM OF ACETYLCHOLINESTERASE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Publication number: 20230010368
    Abstract: The present invention provides a crystalline form of an acetylcholinesterase inhibitor, a preparation method therefor and application thereof. Specifically, the crystalline form is crystalline form A, crystalline form B and crystalline form C of 2-((1-(2-fluorobenzyl)-4-fluoropiperidin-4-yl) methylene)-5, 6-dimethoxy-2, 3-dihydro-1-indanone. The crystalline form of the present invention does not contain water and solvent, has high stability and low hygroscopicity, is easy to process, and is very suitable for preparing drugs for preventing and/or treating neurodegenerative diseases.
    Type: Application
    Filed: November 24, 2020
    Publication date: January 12, 2023
    Inventors: Hong LIU, Yu ZHOU, Haiyan ZHANG, Yan FU, Jian LI, Hualiang JIANG, Xican TANG, Kaixian CHEN
  • Fluorine substituted cyclic amine compounds and preparation methods, pharmaceutical compositions, and uses thereof
    Patent number: 9637454
    Abstract: The present invention relates to the field of pharmaceutical chemistry and pharmacotherapeutics, and in particular to compounds of general formula I, racemates, R-isomers, S-isomers, and pharmaceutically acceptable salts thereof and their mixtures, and the preparation methods thereof and a pharmaceutical composition containing the compounds and uses thereof as an acetylcholine esterase inhibitor.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: May 2, 2017
    Assignee: SHANGHAI INSTITUTE OF MATERIA MADICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Hong Liu, Haiyan Zhang, Yu Zhou, Yan Fu, Hualiang Jiang, Xican Tang, Kaixian Chen
  • FLUORINE SUBSTITUTED CYCLIC AMINE COMPOUNDS AND PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Publication number: 20150284331
    Abstract: The present invention relates to the field of pharmaceutical chemistry and pharmacotherapeutics, and in particular to compounds of general formula I, racemates, R-isomers, S-isomers, and pharmaceutically acceptable salts thereof and their mixtures, and the preparation methods thereof and a pharmaceutical composition containing the compounds and uses thereof as an acetylcholine esterase inhibitor.
    Type: Application
    Filed: October 17, 2013
    Publication date: October 8, 2015
    Inventors: Hong Liu, Haiyan Zhang, Yu Zhou, Yan Fu, Hualiang Jiang, Xican Tang, Kaixian Chen
  • Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent
    Patent number: 7332495
    Abstract: Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also disclosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: February 19, 2008
    Assignees: Nhwa Pharma. Corporation, Shanghai Institute of Pharmaceutical Industry
    Inventors: Jianqi Li, Liying Huang, Chunnian Zhang, Xican Tang, Guoyuan Hu
  • Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent
    Publication number: 20060148811
    Abstract: Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also dislcosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.
    Type: Application
    Filed: April 16, 2004
    Publication date: July 6, 2006
    Applicant: Shanghai Institute of Pharmaceutical Industry
    Inventors: Jianqi Li, Liying Huang, Chunnian Zhang, Xican Tang, Guoyuan Hu
  • Huperzine A derivatives, their preparation and their use
    Patent number: 5929084
    Abstract: The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is ##STR1## or R" and Y together form .dbd.CH; R is (C.sub.1 -C.sub.5) alkyl, ##STR2## wherein n is 0 or 1, X is H, (C.sub.1 -C.sub.5) alkyl; (C.sub.1 -C.sub.5) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis-(C.sub.1 -C.sub.5) alkyl; --(CH.sub.2).sub.m COOZ, wherein m=0-5, Z is H or (C.sub.1 -C.sub.5) alkyl; --CH.dbd.CH--G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl substituted by (C.sub.1 -C.sub.5) alkyl at the nitrogen atom; R' is H, (C.sub.1 -C.sub.5) alkyl, pyridoyl, benzoyl substituted by (C.sub.1 -C.sub.5) alkyloxy; R" is H or (C.sub.1 -C.sub.5) alkyl; processes for their use as acetylcholinesterase inhibitor.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: July 27, 1999
    Assignee: Shangahi Institute of Materia Medica Chinese Academy of Sciences
    Inventors: Dayuan Zhu, Xican Tang, Jinlai Lin, Cheng Zhu, Jingkang Shen, Guansong Wu, Shanhao Jiang, Takuji Yamaguchi, Kazuhiro Tanaka, Takeshi Wakamatsu, Hiroaki Nishimura
  • Huperzine A derivatives, their preparation and their use
    Patent number: RE38460
    Abstract: The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is or R″ and Y together form ═CH; R is (C1-C5) alkyl, wherein n is 0 or 1, X is H, (C1-C5) alkyl; (C1-C5) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis-(C1-C5) alkyl; —(CH2)m COOZ, wherein m=0-5, Z is H or (C1-C5) alkyl; —CH═CH—G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl substituted by (C1-C5) alkyl at the nitrogen atom; R′ is H, (C1-C5) alkyl, pyridoyl, benzoyl substituted by (C1-C5) alkyloxy; R″ is H or (C1-C5) alkyl; processes for their use as acetylcholinesterase inhibitor.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: March 9, 2004
    Assignee: Shanghai Institute of Materia Medica Chinese Academy of Sciences
    Inventors: Dayuan Zhu, Xican Tang