Abstract: The disclosure provides palatable nutritional supplements, foods cosmetic or pharmaceutical acceptable compositions that can be administrated orally, topically or parenterally in a solid, aqueous, cream, gel or ointment dosage form, containing one or more of the purine alkaloids bioactive compounds including 1,3,7-trimethyluric acid salts, for example water soluble mineral salts thereof such as 1,3,7-trimethyluric acid sodium, calcium, magnesium, potassium salts but not limited to these or salts in a form of citrates, malates, glutarates, fumarates, adipates, phosphates, nitrates, hydrochlorites, sulfates, succinates, acetates salts but not limited to these; it also provide compositions and usage of 1,3,7-trimethyluric acid, 1,7-dimethyluric acid, 1-methyluric acid, 9-methyluric acid, 3,7-dimethyluric acid in a form of salts or co-crystals that is easily soluble in water and not bitter or easily to be masked and flavored when dissolved in a natural or artificial flavored powder drink mix or a ready to drink n