Abstract: The disclosure features compositions and methods for the treatment of inner ear dysfunction, such as hearing loss or vestibular dysfunction, that reduce inflammatory or cell-mediated immune toxicity in the inner ear, thereby improving transduction and therapeutic efficacy. The disclosure provides a variety of compositions that include a nucleic acid vector that contains a polynucleotide encoding a therapeutic agent operably linked to a ubiquitous promoter and inhibitor of inflammatory or immune cell signaling. The disclosed compositions and methods can be used to increase expression of the therapeutic agent in a subject, such as a human subject suffering from an inner ear dysfunction, while minimizing undesirable immune activation resulting from off-target expression of the target protein in immune cells of the inner ear.

Abstract: An example topology construction method for satisfying partition tolerance, comprising: combining the consortium blockchain consensus mechanism with the network topology structure to make the consortium blockchain consensus satisfy the partition tolerance in probability; abstracting the partition tolerance of a system into a class of convergent Markov process and computing a steady-state probability of the system; estimating the probability and the average minimum repair time of failing to meet consistency or availability in the event of a partition failure with a given number of failure channels, and a partition tolerance probability and an average minimum repair time of the system are obtained; and analyzing the resource overhead and the partition tolerance under different network topologies according to the obtained partition tolerance probability and the average minimum repair time, and constructing the network topology structure with suitable scale and high partition tolerance for the consortium blockcha

Abstract: The present application is applied to lamp field, and a ultrathin lamp is provided, which is configured such that a support table is provided on a mounting base and ratio of the width of the support table to the thickness of the thickest portion of the support table is set to 5.5 to 10, such that under the conditions of satisfying technological feasibility of the support base, the whole thickness of the support table and the lamp can be relatively thin, so that the overall appearance is more decorative and thus satisfying the ultrathin requirements on the market.

Abstract: The present application is applied to lamp field, and a ultrathin lamp is provided, which is configured such that a support table is provided on a mounting base and ratio of the width of the support table to the thickness of the thickest portion of the support table is set to 5.5 to 10, such that under the conditions of satisfying technological feasibility of the support base, the whole thickness of the support table and the lamp can be relatively thin, so that the overall appearance is more decorative and thus satisfying the ultrathin requirements on the market.

Abstract: A compatible downlight is mounted in a mounting hole (90) of a ceiling (9), the compatible downlight comprises a lamp body (1) and a first conducting wire (2) led out from an inside of the lamp body (1) and electrically connected with the lamp body (1); the compatible downlight further comprises a wiring component (3) configured to connect with an external power supply and two elastic members (4) configured for positioning and fixing the lamp body (1); each of the elastic members (4) can be fixedly connected to and detached from the lamp body (1); in addition, the first conducting wire (2) is electrically connected with the wiring component (3).