Patents by Inventor Xifu Liang

Xifu Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE MODULATORS OF IL-17
    Publication number: 20230250079
    Abstract: The present disclosure relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The disclosure further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
    Type: Application
    Filed: June 10, 2021
    Publication date: August 10, 2023
    Inventors: Mark ANDREWS, Morten Dahl SØRENSEN, Mogens LARSEN, Nicolas DEVAUX, Vinicius BARROS RIBEIRO DA SILVA, Quentin PERRON, Xifu LIANG, Jimmi Gerner SEIZBERG
  • SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20220362259
    Abstract: The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
    Type: Application
    Filed: June 10, 2021
    Publication date: November 17, 2022
    Inventors: Xifu LIANG, Jens LARSEN, Simon Feldbaek NIELSEN, Peter ANDERSEN
  • Small molecule modulators of IL-17
    Patent number: 11377425
    Abstract: The present invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: July 5, 2022
    Assignee: Leo Pharma A/S
    Inventors: Kevin Neil Dack, Xifu Liang, Mogens Larsen, Mark Andrews, Alan Stuart Jessiman, Mia Nørreskov Burhardt, Patrick Stephen Johnson, Peter Andersen, Lars Jørgensen
  • SMALL MOLECULE MODULATORS OF IL-17
    Publication number: 20220162191
    Abstract: The present invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
    Type: Application
    Filed: March 6, 2020
    Publication date: May 26, 2022
    Inventors: Xifu LIANG, Kevin Neil DACK, Peter ANDERSEN, Morten Dahl SØRENSEN, Mark ANDREWS, Alan Stuart JESSIMAN
  • Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
    Patent number: 11065257
    Abstract: The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: July 20, 2021
    Assignee: LEO Pharma A/S
    Inventors: Xifu Liang, Jens Larsen, Simon Feldbaek Nielsen, Peter Andersen
  • Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
    Patent number: 10906915
    Abstract: The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: February 2, 2021
    Assignee: LEO Pharma A/S
    Inventors: Xifu Liang, Jens Larsen, Simon Feldbaek Nielsen, Peter Andersen
  • SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20200323869
    Abstract: The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
    Type: Application
    Filed: December 12, 2017
    Publication date: October 15, 2020
    Applicant: LEO Pharma A/S
    Inventors: Xifu LIANG, Jens LARSEN, Simon Feldbaek NIELSEN, Peter ANDERSEN
  • Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors
    Patent number: 10793580
    Abstract: The present invention relates to novel pyrazoloazepin-8-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: October 6, 2020
    Assignee: LEO Pharma A/S
    Inventors: Xifu Liang, Jens Larsen
  • SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20200010477
    Abstract: The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
    Type: Application
    Filed: December 12, 2016
    Publication date: January 9, 2020
    Inventors: Xifu LIANG, Jens LARSEN, Simon Feldbaek NIELSEN, Peter ANDERSEN
  • SUBSTITUTED PYRAZOLOAZEPIN-8-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20190330223
    Abstract: The present invention relates to novel pyrazoloazepin-8-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
    Type: Application
    Filed: December 12, 2016
    Publication date: October 31, 2019
    Inventors: Xifu LIANG, Jens LARSEN
  • INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
    Publication number: 20170217910
    Abstract: The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Application
    Filed: April 14, 2017
    Publication date: August 3, 2017
    Applicant: LEO LABORATORIES LIMITED
    Inventors: Gunnar GRUE-SØRENSEN, Xifu LIANG, Thomas HÖGBERG, Kristoffer MÅNSSON, Per VEDSØ, Thomas VIFIAN
  • Ingenol-3-acylates III and ingenol-3-carbamates
    Patent number: 9708286
    Abstract: The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: July 18, 2017
    Assignee: LEO LABORATORIES LIMITED
    Inventors: Gunnar Grue-Sørensen, Xifu Liang, Thomas Högberg, Kristoffer Månsson, Per Vedsø, Thomas Vifian
  • Method of producing ingenol-3-angelate
    Patent number: 9676698
    Abstract: The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: June 13, 2017
    Assignee: LEO Laboratories Limited
    Inventors: Thomas Hogberg, Gunnar Grue-Sorensen, Xifu Liang, Anne Marie Horneman, Anders Klarskov Petersen
  • 3-acyl-ingenols II
    Patent number: 9656945
    Abstract: The invention relates to compounds of general formula I, (I), wherein R is wherein R is aryl substituted by R3; or R is (C3-Ci3)-cycloalkyl, (C3-Ci3)-cycloalkenyl or (C7-Ci3)-cycloalkynyl optionally substituted by R4; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: May 23, 2017
    Assignee: LEO LABORATORIES LIMITED
    Inventors: Gunnar Grue-Sørensen, Xifu Liang, Thomas Högberg, Kristoffer Månsson, Per Vedsø
  • Process for the preparation of ingenol-3-angelate from 20-deoxy-ingenol
    Patent number: 9624157
    Abstract: The present invention provides a method for preparing ingenol-3-angelate.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: April 18, 2017
    Assignee: LEO Laboratories Limited
    Inventor: Xifu Liang
  • METHOD OF PRODUCING INGENOL-3-ANGELATE
    Publication number: 20160280627
    Abstract: The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.
    Type: Application
    Filed: June 9, 2016
    Publication date: September 29, 2016
    Inventors: Thomas Hogberg, Gunnar Grue-Sorensen, Xifu Liang, Anne Marie Horneman, Anders Klarskov Petersen
  • 3-O-heteroaryl-ingenol
    Patent number: 9422309
    Abstract: The present invention relates to a compound according to formula (I) wherein R1 represents optionally substituted heteroaryl, and pharmaceutically acceptable salts, hydrates, solvates or pharmaceutically acceptable and physiologically cleavable esters thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. diseases associated with hyperplasia, neoplasia or dysplasia, with said compounds, to methods of treatment of cosmetic indications with said compounds, and to the use of said compounds in the manufacture of medicaments.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: August 23, 2016
    Assignee: LEO LABORATORIES LIMITED
    Inventors: Xifu Liang, Thomas Högberg, Bjarne Nørremark, Kristoffer Månsson, Carsten Ryttersgaard, Gunnar Grue-Sørensen
  • Method of producing ingenol-3-angelate
    Patent number: 9416084
    Abstract: The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: August 16, 2016
    Assignee: LEO Laboratories Limited
    Inventors: Thomas Hogberg, Gunnar Grue-Sorensen, Xifu Liang, Anne Marie Horneman, Anders Klarskov Petersen
  • Process for the preparation of ingenol-3-angelate
    Patent number: 9404131
    Abstract: The invention relates to methods for preparing ingenol-3-angelate from ingenol or ingenol derivatives.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: August 2, 2016
    Assignee: LEO Laboratories Limited
    Inventors: Xifu Liang, Thomas Hogberg, Gunnar Grue-Sorensen, Thomas S. Moody, Andrew S. Rowan
  • Ingenol-3-acylates I
    Patent number: 9388124
    Abstract: The invention relates to compounds of general formula (I) wherein R is (C1-C7)alkyl, (C2-C7)alkenyl or (C2-C7)alkynyl; wherein R is substituted with R1; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: July 12, 2016
    Assignee: LEO LABORATORIES LIMITED
    Inventors: Gunnar Grue-Sørensen, Xifu Liang, Thomas Högberg