Patents by Inventor Xihe CHEN

Xihe CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS
    Publication number: 20240052010
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Application
    Filed: October 11, 2023
    Publication date: February 15, 2024
    Inventors: Xiangjun Zhou, Yanyan Han, Xihe Chen
  • METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS
    Publication number: 20230212253
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Application
    Filed: June 17, 2022
    Publication date: July 6, 2023
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xihe CHEN
  • METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS
    Publication number: 20230023834
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Application
    Filed: June 17, 2022
    Publication date: January 26, 2023
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xihe CHEN
  • METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS
    Publication number: 20220403000
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Application
    Filed: June 17, 2022
    Publication date: December 22, 2022
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xihe CHEN
  • METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS
    Publication number: 20220402999
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Application
    Filed: June 17, 2022
    Publication date: December 22, 2022
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xihe CHEN
  • Methods of cancer treatment using tumor antigen-specific T cells
    Patent number: 11471519
    Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: October 18, 2022
    Assignees: SYZ Cell Therapy Co., HRYZ (Shenzhen) Biotech Co.
    Inventors: Xiangjun Zhou, Yanyan Han, Xihe Chen, Xiaoling Liang
  • Methods of obtaining tumor-specific T cell receptors
    Patent number: 11390659
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: July 19, 2022
    Assignees: SYZ Cell Therapy Co., HRYZ (Shenzhen) Biotech Co.
    Inventors: Xiangjun Zhou, Yanyan Han, Xiaoling Liang, Xihe Chen
  • METHODS OF CANCER TREATMENT USING TUMOR ANTIGEN-SPECIFIC T CELLS
    Publication number: 20220125904
    Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.
    Type: Application
    Filed: January 7, 2022
    Publication date: April 28, 2022
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xihe CHEN, Xiaoling LIANG
  • Methods of cancer treatment using tumor antigen-specific T cells
    Patent number: 11219676
    Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: January 11, 2022
    Assignees: SYZ Cell Therapy Co., HRYZ (Shenzhen) Biotech Co.
    Inventors: Xiangjun Zhou, Yanyan Han, Xihe Chen, Xiaoling Liang
  • METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS
    Publication number: 20210198341
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Application
    Filed: April 12, 2019
    Publication date: July 1, 2021
    Applicants: SYZ Cell Therapy Co., HRYZ (Shenzhen) Biotech Co.
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xiaoling LIANG, Xihe CHEN
  • METHODS OF CANCER TREATMENT USING TUMOR ANTIGEN-SPECIFIC T CELLS
    Publication number: 20210154285
    Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.
    Type: Application
    Filed: April 12, 2019
    Publication date: May 27, 2021
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xihe CHEN, Xiaoling LIANG