Abstract: Provided herein are polynucleotide constructs comprising codon-optimized SLC52A2 gene, vectors (viral or non-viral vectors) comprising the polynucleotide constructs, methods of using the polynucleotide constructs for delivery of an SLC52A2 polynucleotide construct to a cell or a subject, and methods of using the polynucleotide constructs for treating SLC52A2 deficiency such as Riboflavin Transporter Deficiency (RTD).

Abstract: A method and system for predicting regional gas consumption, and a device and a cloud platform. The future gas consumption of all gas users in an entire region is predicted according to a user-specified region and date; all networked gas users in the region are extracted during a prediction process by using spatial address matching technology; and then, by means of classifying the users and sampling the users in combination with statistics, representative sample users are extracted from all the users for respective prediction, thereby reducing the computation amount and computing resource consumption, which are required for model prediction. The method and system is mounted on a cloud platform, and the cloud platform receives, by means of Internet of Things technology, gas flow data that is uploaded by gas flow metering devices of all networked gas users, and also provides an interface for interacting with the users for the outside.

Abstract: This application provides a method for processing a virtual concert performed by a computer device. The method includes: receiving a concert creation instruction for a target singer; creating a concert room for simulating singing a song of the target singer in response to the concert creation instruction; collecting a singing content of the song of the target singer in the simulated singing of a current object; and playing the singing content through the concert room to terminals of objects.

Abstract: A method includes acquiring multiple pieces of first received signal quality information at a receiver, where the multiple pieces of first received signal quality information represent qualities of signals received at the receiver, generating first conditional sample statistical values based on the multiple pieces of first received signal quality information and phase shift arrays corresponding to the signals, determining the first phase shift array that meets a communication requirement according to the first conditional sample statistical values, where the first phase shift array includes the phase shift value for at least one reflective element of an IRS, and configuring the IRS based on the first phase shift array.

Abstract: A child safety seat includes a backrest; a headrest formed with a shoulder belt hole; and a shoulder belt extending through the shoulder belt holes, wherein a back surface of the headrest has a first connector and a front surface of the backrest has a second connector, and the first connector is attached to the second connector in a height adjustable manner. The child safety seat may synchronously adjust the height of the shoulder belt while adjusting the height of the headrest.

Abstract: Disclosed herein is a compound of formula (I). An application of the compound of formula (I) or a stereoisomer thereof in the preparation of a drug for inhibiting interleukin-17A (IL-17A) is further provided.

Abstract: A method and an apparatus for measuring ultrasonic viscoelasticity, a device and a medium are provided. The method includes: establishing an inhomogeneous viscoelastic wave equation; coding the inhomogeneous viscoelastic wave equation as a loss function, and constructing a physics-informed neural network, where the spatial-temporal neural network is configured to predict a stream function, the inhomogeneous viscoelastic wave equation is used to obtain vertical vibration velocity of particles based on the stream function outputted, the spatial neural network is configured to predict shear modulus and viscosity, and the loss function is used to calculate an aggregate loss; inputting the multi-frame vertical vibration velocity of particles of the object to be measured as supervisory data into the physics-informed neural network, to obtain a spatial distribution of the shear modulus and a spatial distribution of the viscosity of the object to be measured.

Abstract: A free-cutting titanium material and a preparation process thereof are provided. The free-cutting titanium material includes a matrix component group and a free-cutting component group, and at least one free-cutting component group is added to the matrix component group; the matrix component group includes the following in percentage by mass: iron (Fe): 0-1.0%; nitrogen (N): 0-0.08%; hydrogen (H): 0-0.02%; oxygen (O): 0-0.50%; aluminium (Al): 0-8.0%; vanadium (V): 0-15.0%, and a balance being titanium and unavoidable impurities; and the free-cutting component group respectively refers to: a rare earth (RE) and sulfur (S) group, a copper (Cu) and S group, a zirconium (Zr) group, a carbon (C) group, a boron (B) group, or a magnesium (Mg) group. The free-cutting titanium material is prepared by any one of three methods: vacuum consumable melting, vacuum suspension melting, and powder metallurgy. The present disclosure enhances the machinability of the titanium material.

Abstract: An SNP marker significantly related with yardlong bean anthocyanin content is provided in the present disclosure. The SNP marker significantly related with yardlong bean anthocyanin content is located at the position of 2,361,292 bp on chromosome 5 of yardlong bean genome v1.2, with a base A to G substitution, and the nucleotide sequence thereof is shown in SEQ ID NO. 1. KASP marker based on the SNP marker significantly related with the yardlong bean anthocyanin content and application thereof are also provided in the present disclosure. The KASP marker and the SNP marker significantly related with yardlong bean anthocyanin content are applied for molecular marker-assisted selection breeding of yardlong bean anthocyanin traits.

Abstract: A compound represented by structural formula (I) and a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound or the pharmaceutically acceptable salt thereof, can be used for treating diseases such as obesity, hyperlipidemia, hypercholesterolemia, and diabetes and also for treating other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other related disorders and diseases

Abstract: Disclosed are a pose decoupling kinematics calibration method, device and apparatus, and a storage medium. The method includes the following steps: constructing a pose decoupling motion model based on an equivalent rotation vector and a rigid body motion transformation rule; introducing a pose error, and carrying out pose space decomposition through the pose decoupling motion model to obtain an orientation error expression and a position equivalent expression; analyzing a coupling influence of an orientation change on a position according to the orientation error expression and the position equivalent expression to obtain a pose coupling increment; constructing a target decoupling calibration model according to the pose coupling increment and an initial decoupling calibration model; and solving geometric errors in different degrees of freedom for the target decoupling calibration model according to a preset axis pose error by a least square method to obtain a calibration error.

Abstract: Computer security improvements relating to fraud detection and data correlations through large-scale graph clustering of graph transformations and embeddings are disclosed. A service provider may utilize a framework having computing operations for detecting fraud and other malicious or suspicious activities by groups of accounts and fraudsters. In this regard, the service provider may transform relationship graphs of account networks and relationships between accounts and account data captured in the nodes and edges of such graphs. The service provider may merge nodes that edges connecting to other nodes of a certain type of account data, while other types of account data and nodes may not be merged. Edges may also be merged and weighted, and the resulting transformed graph may undergo graph embedding to generate vectors that may be clustered using an AI clustering algorithm. The clusters may then be used for AI model training and inferencing.

Abstract: The present disclosure provides compounds of formula (I) having receptor protein tyrosine kinase activity, and a pharmaceutically acceptable salt, stereoisomers, isotopic isomers thereof. The compounds of the present disclosure have high biological activity and can be used to treat diseases or disorders related to the target.

Abstract: A dynamic loading method and an electronic device are disclosed. The method includes: parsing one or more target files, and storing one or more first parsing results, where the one or more first parsing results are in a one-to-one correspondence with the one or more target files, the one or more target files include an executable file or a dynamic library file; searching the one or more first parsing results for a first parsing result of a dynamic library file on which a first executable file depends; and mapping, based on the first parsing result of the dynamic library file, the dynamic library file into a process address space in which the first executable file is located.

Abstract: Provided are a light-emitting diode and a light-emitting device. The light-emitting diode includes an epitaxial structure, a first electrode, and a second electrode. The epitaxial structure includes a first semiconductor layer, an active layer, and a second semiconductor layer alternately stacked in sequence. The first electrode is located on the epitaxial structure and electrically connected to the first semiconductor layer. The second electrode is located on the epitaxial structure and electrically connected to the second semiconductor layer. The first electrode and/or the second electrode has a titanium-free stack structure. Through the above arrangement, an anti-aging capability of a chip may be enhanced, thereby improving the reliability of the chip.

Abstract: A method of testing an expansion card includes configuring a configuration file according to contents of instructions of a controller, which may be received by the expansion card, and contents of expected data corresponding to the instructions. Testing instructions are generated based on the configuration file. The testing instructions are sent to the expansion card. Returned data returned from a firmware of the expansion card by responding the testing instructions. Whether an electronic device communicates with the expansion card successfully is determined based on the returned data. An electronic device and a testing system are also provided.

Abstract: A rapid active vibration reduction method for a high-speed motion stage includes acquiring motion parameters of a motion body of the motion stage in current motion; determining a vibration reduction mode of a vibration reduction device according to the motion parameters; and controlling an action end of the vibration reduction device to contact with the motion body of the motion stage or contact with a driving device for driving the motion body to move based on the vibration reduction mode, so that a contact friction force used for suppressing vibration of the motion body is generated. Realizing vibration reduction by means of active friction can reduce vibration of the motion body in a specific stage needing vibration reduction, and the action end of the vibration reduction device does not need to contact with the motion body or does not need to contact with the driving device before vibration reduction.

Abstract: The invention relates to the technical field of thermal power generation, and discloses a crack prediction method and apparatus, an electronic device and a computer-readable storage medium. The method includes: detecting a magnetic flux leakage at a to-be-detected welding joint; and predicting, based on the magnetic flux leakage at the to-be-detected welding joint, a tendency of the to-be-detected welding joint to have a crack. This allows for the prevention of cracking at the joint or for timely repair and preventive treatment at locations of potential crack, thereby improving operation safety of units.

Abstract: The invention relates to compounds which inhibit CDK4 (Cyclin-Dependent Kinase 4 or Cell Division protein Kinase 4), and to processes for the preparation of said compounds, pharmaceutical compositions comprising said compounds, and use of said compounds in the treatment of conditions, diseases and disorders mediated by CDK4.