Abstract: Provided herein are compositions and methods for reducing toxicity associated with TAR DNA-binding protein 43. Certain embodiments of the present disclosure are related to compositions that treat, inhibit, reduce, prevent, or delay a disease or condition associated with TDP-43 toxicity, such as cystic fibrosis or neurodegenerative diseases. Certain embodiments of the present disclosure are related to methods of treating, inhibiting, reducing, preventing, or delaying a disease or condition associated with TDP-43 toxicity by administering compounds of any one of Formulas (I), (II), (III), (IV), (V), (VI), (VII), or (VIII) to a subject in need.

Abstract: Provided herein are compositions and methods for reducing toxicity associated with TAR DNA-binding protein 43. Certain embodiments of the present disclosure are related to compositions that treat, inhibit, reduce, prevent, or delay a disease or condition associated with TDP-43 toxicity, such as cystic fibrosis or neurodegenerative diseases. Certain embodiments of the present disclosure are related to methods of treating, inhibiting, reducing, preventing, or delaying a disease or condition associated with TDP-43 toxicity by administering compounds of any one of Formulas (I), (II), (III), (IV), (V), (VI), (VII), or (VIII) to a subject in need.

Abstract: A method comprising: A. forming a consortium blockchain network using domain network nodes and selecting committee members from top-level domain nodes; B. the committee member who received most votes packs the genesis block and generates a random number; C. the housekeeper having the same number as the random number packs the current block and generates a random number for selecting a next housekeeper to pack the next block, each block is approved by more than half of the committee members; D. during the duty cycle, each housekeeper takes turns packing blocks and generating random numbers and the process is repeated. If a block is not approved, the housekeeper with the next number is requested to repack the block; and E. the last random number generated by a housekeeper before the duty cycle ends is used to select the housekeeper to pack the first block of the next duty cycle.