Abstract: The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.

Abstract: Disclosed in the disclosure are a method and apparatus for calibrating an exposure surface of an optical system, and a computer device and a storage medium. The method includes: performing flat-field correction on a photographing module; acquiring a grayscale distribution image; segmenting the grayscale distribution image into a mesh image including a plurality of segmented regions, and calculating a fitting grayscale value of each segmented region; selecting, as a reference grayscale value, a minimum fitting grayscale value from all the fitting grayscale values obtained through calculation, and calculating grayscale compensation coefficients corresponding to the other segmented regions, so as to generate a digital mask; and performing mask compensation, by using the digital mask, on a light projection image projected by the optical system, so as to obtain a printed image of which the exposure surface has a uniform irradiance value.

Abstract: Provided are a game system, a game method, a game program, and a game server capable of, in a game in which a plurality of players can participate, contributing to a team through behaviors other than interpersonal battles in the game and encouraging fight together with other players. A game system 1 comprising: a character state decision unit 50 that is configured to decide a state of a neutral character based on a result of a fight between the neutral character and a player character; and a point giving control unit 62 that is configured to control a giving of points of the neutral character to a player, wherein the point giving control unit 62 is further configured to automatically give the points to the player if a first condition is satisfied, and cause a point object to appear in a play field and make the point object available for acquisition by any player of an ally team and an enemy team if a second condition is satisfied.

Abstract: Provided are an audio/video processing method and apparatus, a device, and a storage medium. The method comprises: displaying text data corresponding to an audio/video to be edited, wherein the text data has a mapping relation with an audio/video timestamp of said audio/video; displaying said audio/video according to a time axis track; in response to a preset operation triggered for target text data in the text data, determining an audio/video timestamp corresponding to the target text data as a target audio/video timestamp; and processing, on the basis of the preset operation, an audio/video clip corresponding to the target audio/video timestamp in said audio/video.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that obtain scene features in an environment that includes an autonomous vehicle and a target agent at a current time point; determine whether the target agent is an emergency vehicle that is active at the current time point; generate from the scene features, an input (i) that includes the scene features and (ii) that indicates whether the target vehicle is an emergency vehicle that is active at the current time point; and process the input using a machine learning model that is configured to generate a behavior prediction output for the target agent that characterizes predicted future behavior of the target agent after the current time point.

Abstract: The present application relates to a top plate jacking device and jacking construction method configured for V-shaped columns, the top plate jacking device comprising a temporary support pile comprises a plurality of pile holes arranged on a construction surface, a bottom end of the pile hole is cast-in-place with a bearing platform, a temporary support column is inserted on the bearing platform, a plurality of pillars are fixed at a top of the temporary support column, wherein comprises a plurality of vertically connected column segments, two adjacent column segments detachably connected vertically through a connecting component; a support block is provided at a top of the plurality of pillars, the top of the support block abuts against a lower surface of the top plate; a hydraulic jack is configured to jack the top plate and is provided with a plurality of intervals at the top of the temporary support column.

Abstract: The present disclosure provides a direct current (DC) transformer error detection apparatus for a pulsating harmonic signal, including a DC and pulsating harmonic current output module and an external detected input module, where the DC and pulsating harmonic current output module outputs a DC and a DC superimposed pulsating harmonic current to an internal sampling circuit and a self-calibrated standard resistor array; and the internal sampling circuit converts the input DC and the input DC superimposed pulsating harmonic current into a voltage signal, and sends the voltage signal to an analog-to-digital (AD) sampling and measurement component through a front-end conditioning circuit and a detected input channel. The DC transformer error detection apparatus can complete self-calibration for measurement of the DC and the pulsating harmonic signal on a test site.

Abstract: A wrinkle detection method includes: rotating a region, in a face image, in which a wrinkle needs to be detected, to obtain a plurality of to-be-detected images; determining wrinkle points from all pixel points based on grayscale values of the pixel points in each of the to-be-detected images with different angles; determining at least one wrinkle line based on the wrinkle points; and then displaying, by the electronic device, the wrinkle line in the region in which the wrinkle needs to be detected, where each wrinkle line indicates one wrinkle in each of the to-be-detected images.

Abstract: A resource processing method and apparatus. The method is achieved by a computer configured to execute the following steps: generating a resource allocation chart based on a resource allocation request; processing the resource allocation chart and generating an access entrance of the resource allocation chart; opening the access entrance to enable at least one third party resource supplier to respond to the resource allocation request via the access entrance. The method further comprises: when the resources are not available or not suitable for allocation, receiving a resource allocation chart, wherein the resource allocation chart is based on the resource allocation request; generating an access entrance of the resource allocation chart; opening the access entrance to at least one third party resource supplier; and receiving the allocated resources from the at least one third party resource supplier by responding to the resource allocation request through the access entrance.

Abstract: An approach is provided in which the approach receives an image that includes multiple image points and constructs a plane in the image based on a first subset of the plurality of image points. The approach identifies a second subset of the image points that belong to the plane and are not part of the first subset of image points, and removes the first subset of image points and the second subset of image points form the image points. The approach annotates the remaining subset of image points in the image.

Abstract: A method for obstacle avoidance in degraded environments of robots based on intrinsic plasticity of an SNN is disclosed. A decision network in a synaptic autonomous learning module takes lidar data, distance from a target point and velocity at a previous moment as state input, and outputs the velocity of left and right wheels of the robot through the autonomous adjustment of the dynamic energy-time threshold, so as to carry out autonomous perception and decision making. The method solves the difficulty of the lack of intrinsic plasticity in the SNN, which leads to the difficulty of adapting to degraded environments due to the homeostasis imbalance of the model, is successfully deployed in mobile robots to maintain a stable trigger rate for autonomous navigation and obstacle avoidance in degraded, disturbed and noisy environments, and has validity and applicability on different degraded scenes.

Abstract: An image acquisition method includes acquiring a first image based on a first photographing parameter, where the first image includes a first to-be-detected item, acquiring a second image based on a second photographing parameter, where the second image includes a second to-be-detected item, and determining, based on the first image and the second image, a detection result corresponding to the first to-be-detected item and a detection result corresponding to the second to-be-detected item.

Abstract: A skin detection method includes: dividing a region of interest in a face image into a highlighted region and a non-highlighted region; separately determining a first segmentation threshold of the highlighted region and a second segmentation threshold of the non-highlighted region; obtaining a binary image of the highlighted region based on the first segmentation threshold, and obtaining a binary image of the non-highlighted region based on the second segmentation threshold; fusing the binary image of the highlighted region and the binary image of the non-highlighted region; and identifying, based on a fused image, pores and/or blackheads included in the region of interest.

Abstract: Technology is disclosed for controlling the processing and presentation of group data on computing devices to provide improved computing applications, electronic communications, and user computing experiences. Data indicating a group of people may be programmatically determined or inferred, such as from the user activity of a particular user. Group data characterizing the group of people may be generated and contextualized or personalized for the user based on a user context or intent. Aspects of the contextualized group data may be provided to the user in response to an interaction with an indication of the group or group member. The group data may be provided as a set of group information items, and further may be formatted or assembled for presentation based on the user context, and/or may be consumed by a computing application or service to provide an improved user computing experience.

Abstract: A dark circle detection and evaluation method includes: obtaining a to-be-processed image; extracting a dark circle region of interest from the to-be-processed image; performing color clustering on the dark circle region of interest to obtain n types of colors in the dark circle region of interest, where n is a positive integer; recognizing a dark circle region in the dark circle region of interest based on the n types of colors; and obtaining a dark circle evaluation result based on the dark circle region.

Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.

Abstract: Method and devices for training a keypoint estimation network are described. In each training iteration, synthetic images are generated by a generator, each synthetic image being assigned respective assigned keypoints by the generator. Using a prior-iteration of the keypoint estimation network, a set of predicted keypoints is obtained for each synthetic image. Based on an error score between the predicted keypoints and the assigned keypoints, poor quality synthetic images are discarded. The remaining synthetic images, together with real world images, are used to train an updated keypoint estimation network. The performance of the updated keypoint estimation network is validated, and the training iterations are performed until a convergence criteria is satisfied.

Abstract: A photographing method implemented by an electronic device includes receiving a photographing instruction of a user, shooting a primary camera image using a primary camera, shooting a wide-angle image using a wide-angle camera, and generating a three-dimensional (3D) image based on the primary camera image and the wide-angle image, where the 3D image includes a plurality of frames of images that is converted from a 3D viewing angle and corresponds to different viewing angles.

Abstract: A face image processing method and apparatus, a device, and a computer readable storage medium are provided. The face image processing method includes: obtaining a face image; detecting an eye feature based on the face image, and obtaining eye feature data, where the eye feature includes an eyelid and an iris, and the eye feature data includes an eyelid key point, an iris center, and an iris radius; determining an eye adjustment degree based on the eye feature data; and adjusting the eye feature in the face image based on the eye adjustment degree, to obtain a processed image. According to the face image processing method, real-time correction is performed on a human eye sight line in a face image.