Patents by Inventor Xin Dong GUO
Xin Dong GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230381478Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.Type: ApplicationFiled: August 14, 2023Publication date: November 30, 2023Inventors: Devin McAllister, Mark R. Prausnitz, Sebastien Henry, Xin Dong Guo
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Patent number: 11724079Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.Type: GrantFiled: October 1, 2020Date of Patent: August 15, 2023Assignee: Georgia Tech Research CorporationInventors: Devin McAllister, Mark R. Prausnitz, Sebastien Henry, Xin Dong Guo
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Publication number: 20210016071Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.Type: ApplicationFiled: October 1, 2020Publication date: January 21, 2021Inventors: Devin MCALLISTER, Mark R. PRAUSNITZ, Sebastien HENRY, Xin Dong GUO
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Patent number: 10828478Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.Type: GrantFiled: April 24, 2015Date of Patent: November 10, 2020Assignee: Georgia Tech Research CorporationInventors: Devin McAllister, Mark Prausnitz, Sebastien Henry, Xin Dong Guo
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Publication number: 20170050010Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.Type: ApplicationFiled: April 24, 2015Publication date: February 23, 2017Inventors: Devin MCALLISTER, Mark PRAUSNITZ, Sebastien HENRY, Xin Dong GUO
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Patent number: 9101547Abstract: The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery; the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.Type: GrantFiled: July 30, 2012Date of Patent: August 11, 2015Assignee: NANO AND ADVANCED MATERIALS INSTITUTE LIMITEDInventors: Yu Qian, Li Juan Zhang, Zhi Min Wu, Li Ying Zhou, Wei Jiang, Li Ling, Qian Luo, Xin Dong Guo
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Patent number: 8859004Abstract: The present invention discloses the pH-sensitive nanoparticles composed of pH-sensitive polymer, hydrophobic material, internal stabilizer, external stabilizer content and insulin drug. The present invention also includes a method for preparation of pH-sensitive nanoparticles, in particular, a multiple emulsions solvent evaporation method. The pH-sensitive nanoparticles of the present invention show good pH-sensitive property with 100-300 nanometer particle size. Significant decrease in blood glucose level is observed in streptozotocin (STZ)-induced diabetic rats and the bioavailability of insulin is more than 10% after oral administration of the insulin-loaded pH-sensitive nanoparticles.Type: GrantFiled: July 30, 2012Date of Patent: October 14, 2014Assignee: Nano and Advanced Materials Institute LimitedInventors: Lijuan Zhang, Li Ling, Li Ying Zhou, Zhi Min Wu, Xin Dong Guo, Wei Jiang, Qian Luo, Yu Qian
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Publication number: 20130034602Abstract: The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery; the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.Type: ApplicationFiled: July 30, 2012Publication date: February 7, 2013Applicant: NANO AND ADVANCED MATERIALS INSTITUTE LIMITEDInventors: Yu QIAN, Li Juan ZHANG, Zhi Min WU, Li Ying ZHOU, Wei JIANG, Li LING, Qian LUO, Xin Dong GUO
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Publication number: 20130034589Abstract: The present invention discloses the pH-sensitive nanoparticles composed of pH-sensitive polymer, hydrophobic material, internal stabilizer, external stabilizer content and insulin drug. The present invention also includes a method for preparation of pH-sensitive nanoparticles, in particular, a multiple emulsions solvent evaporation method. The pH-sensitive nanoparticles of the present invention show good pH-sensitive property with 100-300 nanometer particle size. Significant decrease in blood glucose level is observed in streptozotocin (STZ)-induced diabetic rats and the bioavailability of insulin is more than 10% after oral administration of the insulin-loaded pH-sensitive nanoparticles.Type: ApplicationFiled: July 30, 2012Publication date: February 7, 2013Applicant: NANO AND ADVANCED MATERIALS INSTITUTE LIMITEDInventors: Lijuan ZHANG, Li LING, Li Ying ZHOU, Zhi Min WU, Xin Dong GUO, Wei JIANG, Qian LUO, Yu QIAN