Abstract: Disclosed herein is a method for producing a sialylated N-glycosylated recombinant protein in periplasm of a recombinant Escherichia coli. The sialylated N-glycosylated recombinant protein is produced in the periplasm of a recombinant Escherichia coli strain W3110?nanKETA::Kan, and a sialylated oligosaccharide chain is Neu5Ac-?-2,6-Gal-?-1,4-GlcNAc-?-1,3-Gal-?-1,3-GlcNAc.

Abstract: The present application provides an application of Chidamide in combination with R-CHOP in preparing a drug used for treating B-cell lymphoma, and also provides a drug comprising Chidamide and R-CHOP. Chidamide in combination with R-CHOP has a synergistic therapeutic effect on B-cell lymphoma.

Abstract: Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2?-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. eads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.

Abstract: The present disclosure provides various embodiments of cases for lifting portable electronic devices (PEDs) from a compartment of the case. Such a case may comprise a compartment with a rear wall and a front wall coupled to the rear wall with a space disposed between the walls. A lift member may be at least partially disposed within the compartment with an end of the lift member coupled to the front wall. The lift member may comprise a handle and a cradle portion. The cradle portion may support the PED within the compartment and upwardly lift the PED relative to the compartment when the handle is upwardly displaced by a user. Accordingly, a larger portion of the PED is exposed outside of the compartment allowing for easy removal of the PED from the compartment.

Abstract: Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2?-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. Leads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.

Abstract: The present invention discloses a film type liquid heater and a uniform heating method thereof. End fixation plates are arranged at two ends of a barrel. A heating pipe is arranged in the barrel. Pipe ports run through the two end fixation plates, respectively. Connecting pipes are arranged in the pipe ports. Sealing connection components are arranged at inner ends of the two connecting pipes. A heating film layer is coated outside the heating pipe. Electrode layers are connected left and right sides of the heating film layer, and the electrode layers are connected to an external power supply. An insulating layer is coated outside the heating film layer. A flow splitting column is fixedly connected in the heating pipe. A heating chamber is formed between an inner side of the heating pipe and the flow splitting column. Flow splitting grooves are formed at left and right ends and on the inner side of the flow splitting column.

Abstract: A method for processing a part using a forming device by laser melting, by: establishing a function, performing first-order and second-order differentiation on the function to obtain a first-order and a second-order derivative, solving the equation that the first-order derivative equals to zero, substituting the roots into the second-order derivative to obtain the roots of the first-order derivative, among which the root with a smallest absolute value is defined as a first value; performing third-order differentiation on the obtained function, solving the equation that the second-order derivative equals to zero to obtain the roots which is defined as second values; subtracting the first value from the second values, and obtaining the second value corresponding to a value that is less than zero and has a smallest absolute value among obtained results, that is a value of the defocus amount to achieve the optimal self-healing effect.

Abstract: The invention provides novel fusion proteins of Interleukin 15 and prodrugs, and compositions and methods of preparation thereof, useful in treating various diseases and disorders (e.g., hyperplasia, solid tumor or hematopoietic malignancy).

Abstract: Disclosed are an immersion liquid supply system and an immersion flow field removal method thereof.

Abstract: A plug connector includes an outer member and an insulated member. The outer member has a receiving groove. One of two ends of the outer member has a mating side, and the other end of the outer member has an assembling side. The outer member includes a mating ring portion, one or more extension portions, and one or more elastic pieces. The mating ring portion is at the mating side. The extension portion, the elastic piece, and the mating ring portion are integrally formed as a one-piece structure. The extension portion extends toward the assembling side from a side end of one side of the mating ring portion, and the elastic piece is bent at an end portion of the extension portion and arranged at a side portion of the extension portion. The insulated member is in the receiving groove.