Abstract: This disclosure relates to isolated oligonucleotides comprising duplex regions targeting human complement C3 mRNA, and delivery systems, kits and compositions comprising the same, and methods of using the same for inhibiting or downregulating C3 gene expression.

Abstract: This disclosure relates to isolated oligonucleotides comprising duplex regions targeting human CFB mRNA, and delivery systems, kits and compositions comprising the same, and methods of using the same for inhibiting or downregulating CFB gene expression.

Abstract: The accuracy of existing machine learning models, software technologies, and computers are improved by estimating whether a particular page belongs to a same document as another page or whether the page belongs to a different document. Such document distinguishing can be based on deriving relationship information between a first feature vector representing the page and a second feature vector representing the other page. This also improves the user experience and model building experience, among other things.

Abstract: This disclosure relates to isolated oligonucleotides comprising duplex regions targeting human complement C3 mRNA, and delivery systems, kits and compositions comprising the same, and methods of using the same for inhibiting or downregulating C3 gene expression.

Abstract: The present invention includes a method for treating a patient suffering from myxomatous mitral valve disease (MMVD), the method comprising administering to the patient an effective amount of a pharmaceutical composition comprising a Prox1 gene, a Prox1 mimic, a PDGF antagonist, or a PDGFRB antagonist that prevents the thickening of heart valves and delays the onset of clinical symptoms of myxomatous valve disease in the patient.

Abstract: A display apparatus and a display panel are disclosed. The display panel includes a display area, a driving area, and a fan-out area provided with a plurality of fan-out wirings and at least including a first section wiring connected with data signal terminals, a second section wiring connected with the first section wiring, and a third section wiring connected with the second section wiring. The fan-out wirings are close to a central axis of the driving area, so that a difference between lengths of the first section wirings on both sides and a length of the first section wiring close to the central axis is reduced, thus effectively shortening the length of the first section wiring close to the central axis when the first section wiring on both sides maintains a predetermined length, therefore, the fan-out area is compressed and a width of the display panel border is shortened.

Abstract: Nanoparticle assemblies can be formed and deposited on temperature sensors to create low cost, high sensitivity hydrogen sensors. The nanoparticle assemblies can be formed from nanoparticles within an electrolysis reactor to form grain-boundary connections between the nanoparticles of the nanoparticle assembly. The nanoparticle assembly can be deposited on temperature sensors to create hydrogen gas sensors.

Abstract: The accuracy of existing machine learning models, software technologies, and computers are improved by estimating whether a particular page belongs to a same document as another page or whether the page belongs to a different document. Such document distinguishing can be based on deriving relationship information between a first feature vector representing the page and a second feature vector representing the other page. This also improves the user experience and model building experience, among other things.

Abstract: The disclosure provides a heterojunction bipolar transistor and a preparation method thereof. Since an emitter region has the same physical structure as a base region, and improves frequency characteristics of the device; Simultaneously with biaxial strain, uniaxial strain is introduced. Carrier transmission time in the collector region will be effectively reduced. By this structure, the width of the effective collector region is reduced, the collector junction capacitance is reduced, and the frequency characteristics of the device are further improved; an appropriate choice of the thickness of the Si cap layer can effectively reduce the accumulation of carriers at an interface and increase the gain of the device; at the same time, the preparation method of the bipolar transistor is completely compatible with a 90-nanometer CMOS process, which effectively reduces the development and manufacturing cost of the device.

Abstract: This disclosure provides a high-voltage terahertz strained SiGe/InGaP heterojunction bipolar transistor and a preparation method thereof. An InGaP material has characteristics of a high carrier mobility of the InP material and a forbidden band width of the GaP material, so that the present disclosure employs the N-type In1-xGaxP layer as the collector to improve the frequency and power characteristics of the device, and realize the system integration of terahertz band chips. Further, the present disclosure utilizes the characteristics of the above materials and takes an advantages of “energy band engineering”, uses the In1-xGaxP (x=0-1) is used as the material of the collector of the SiGe-HBT, the composition molar ratio X of In and Ga is appropriately selected, such that the materials SiGe of the collector and the sub-collector have the same lattice constant, so as to effectively improve interface characteristics of InGaP and SiGe materials.

Abstract: The disclosure provides a heterojunction bipolar transistor and a preparation method thereof. Since an emitter region has the same physical structure as a base region, and improves frequency characteristics of the device; Simultaneously with biaxial strain, uniaxial strain is introduced. Carrier transmission time in the collector region will be effectively reduced. By this structure, the width of the effective collector region is reduced, the collector junction capacitance is reduced, and the frequency characteristics of the device are further improved; an appropriate choice of the thickness of the Si cap layer can effectively reduce the accumulation of carriers at an interface and increase the gain of the device; at the same time, the preparation method of the bipolar transistor is completely compatible with a 90-nanometer CMOS process, which effectively reduces the development and manufacturing cost of the device.

Abstract: This disclosure provides a high-voltage terahertz strained SiGe/InGaP heterojunction bipolar transistor and a preparation method thereof. An InGaP material has characteristics of a high carrier mobility of the InP material and a forbidden band width of the GaP material, so that the present disclosure employs the N-type In1-xGaxP layer as the collector to improve the frequency and power characteristics of the device, and realize the system integration of terahertz band chips. Further, the present disclosure utilizes the characteristics of the above materials and takes an advantages of “energy band engineering”, uses the In1-xGaxP (x=0-1) is used as the material of the collector of the SiGe-HBT, the composition molar ratio X of In and Ga is appropriately selected, such that the materials SiGe of the collector and the sub-collector have the same lattice constant, so as to effectively improve interface characteristics of InGaP and SiGe materials.

Abstract: This disclosure relates to use of certain aldehyde compounds for treating pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as scleroderma, lupus, arthritis and related conditions in a mammal.

Abstract: The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.

Abstract: This disclosure relates to use of certain aldehyde compounds for treating pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as scleroderma, lupus, arthritis and related conditions in a mammal.

Abstract: The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.

Abstract: The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.

Abstract: This disclosure relates to use of certain aldehyde compounds for treating pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as scleroderma, lupus, arthritis and related conditions in a mammal.

Abstract: The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.

Abstract: A system is described for generating a discrete noise-shaped variable switching frequency signal that may be used to define a digital pulse width modulation (“PWM”) period. The system may define a switching frequency waveform that may be used to generate a current switching frequency signal as a function of a system clock. The system may quantize the current switching frequency signal to generate a discrete switching frequency signal that is realizable with the system clock. The system may detect quantization noise and input the noise into the current switching frequency signal to eliminate or reduce discrete tones at the switching frequencies of a PWM signal spectrum.