Abstract: The present disclosure relates to a small molecule inhibitor of cathepsin C and the medicinal use thereof. Specifically, provided in the present disclosure are an amide nitrile compound represented by formula VI, a pharmaceutical composition containing the compound, and the use thereof in the inhibition of cathepsin C.

Abstract: Provided are a method and an apparatus for integrating wireless communication and wireless sensing. The method includes: transmitting, by a communication device, a wireless sensing signal in a target slot position related to a switching point between signal transmission and signal reception of a wireless communication signal; and receiving an echo signal corresponding to the wireless sensing signal in the case that a signal transmission slot of the wireless communication signal is ended.

Abstract: The present invention relates to a method for moderately increasing the content of dimethyl disulfide in casein-containing processed cheese. The method includes the following steps: taking a cheese powder, adding chymosin for enzymolysis, and subjecting a material obtained after the enzymolysis to puffing and drying to obtain a modified cheese powder; preparing materials; taking the modified cheese powder, heating the modified cheese powder under stirring until the cheese powder is melt, adding sodium bicarbonate to adjust the pH to 6-7, and adding papain for enzymolysis; taking a material obtained after the enzymolysis, adding butter, a skimmed milk powder, fructo-oligosaccharide and water for mixing by stirring, and then adding an emulsifying salt, glutamine transaminase and salt for uniform heating and stirring to obtain a mixture; and subjecting the mixture to heat treatment, hot filling and cooling in sequence to obtain processed cheese.

Abstract: The noise reduction earpad includes: an earpad body and an earpad cover, the earpad body is made of a porous flexible material or a foam flexible material and being in a ring shape and being connected to the connection surface, the earpad body and the connection surface jointly forming a sealed and soundproof space provided with a chamber structure having an opening; the earpad cover includes a cloth cover covering at least an exposed outer surface of the earpad body and made of a cloth material and a sealed and soundproof film attached to a side surface of cloth cover facing the earpad body and made of a soft rubber, a laying area of the sealed and soundproof film is corresponding to an outer surface of the earpad body facing away from the sealed and soundproof space.

Abstract: The disclosure provides a vehicle fault diagnosis method and device, and a computer-readable storage medium. The vehicle fault diagnosis method includes: receiving a grayscale image, where the grayscale image represents diagnostic data for vehicle diagnosis; extracting features from the grayscale image by using a convolutional neural network, to generate a feature map; performing self-attention-based processing on the feature map to obtain a classification result, where the classification result indicates a vehicle fault condition; and performing a relevance propagation analysis based on the classification result to obtain a contribution heat map, where the contribution heat map indicates a degree of contribution of each pixel in the grayscale image to the classification result.

Abstract: A sound processing component applied to a string instrument for providing multiple playing forms and a MIDI function. An acquisition module acquires vibration information of multiple strings and outputs analog signals, and a first amplification and filter module amplifies the analog signals and filters the analog signals. A first conversion module converts the analog signals into digital signals, and a processing module identifies playing information of the digital signals, converts the digital signals to MIDI data based on the playing information, converts the MIDI data to audio data, and add audio effects for the audio data. A second conversion module converts the audio data with the audio effects into analog audio signals, and a second amplification and filter module amplifies the analog audio signals, filters the analog audio signals, and transmit the filtered analog audio signals to a loudspeaker. The string instrument is also provided.

Abstract: The invention discloses an effusion cell with a retractable crucible for molecular beam epitaxy, comprising a crucible bracket, a mounting flange, a heat shielding cylinderarranged on an upper side of the mounting flange, a gate valvearranged on a lower side of the mounting flange, an outer cylinderarranged on a lower side of the gate valveand a driving devicefor driving the crucible bracketto move between the heat shielding cylinderand the outer cylinder, the heat shielding cylinderis internally provided with a heater, the outer cylinder driving deviceis hermetically connected to the outer cylinder.

Abstract: The present invention discloses a method for constructing an engineered yeast for glycoprotein preparation and strains thereof. The present invention provides a method for constructing yeast engineered strain having the ability to modify a specific mammalian cell glycoform, comprising: inactivating endogenous ?-1,6-mannose transferase, phosphomannose transferase, phosphomannose synthase, ?-mannose transferase I-IV, and O-mannose transferase I of a receptore yeast; and expressing exogenous mannosidase I, N-acetylglucosamine transferase I, mannosidase II, N-acetylglucosamine transferase II, galactose isomerase and exogenous galactose transferase.

Abstract: The present disclosure provides compositions and methods for minimally invasive optogenetic stimulation. More particularly, the present disclosure provides compositions and methods for using an ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation.

Abstract: A method for preparing needle coke for ultra-high power (UHP) electrodes from heavy oil is provided. In this method, heavy oil is used as a raw material. The size exclusion chromatography (SEC) is conducted with polystyrene (PS) as a packing material to separate out specific components with a relative molecular weight of 400 to 1,000. The ion-exchange chromatography (IEC) is conducted to remove acidic and alkaline components to obtain a neutral raw material. The neutral raw material is subjected to two-stage consecutive carbonization to obtain green coke, and the green coke is subjected to high-temperature calcination to obtain the needle coke for UHP electrodes. The needle coke has a true density of more than 2.13 g/cm3 and a coefficient of thermal expansion (CTE) of ?1.15×10?6/° C. at 25° C. to 600° C.

Abstract: A method for preparing needle coke for ultra-high power (UHP) electrodes from heavy oil is provided. In this method, heavy oil is used as a raw material. The size exclusion chromatography (SEC) is conducted with polystyrene (PS) as a packing material to separate out specific components with a relative molecular weight of 400 to 1,000. The ion-exchange chromatography (IEC) is conducted to remove acidic and alkaline components to obtain a neutral raw material. The neutral raw material is subjected to two-stage consecutive carbonization to obtain green coke, and the green coke is subjected to high-temperature calcination to obtain the needle coke for UHP electrodes. The needle coke has a true density of more than 2.13 g/cm3 and a coefficient of thermal expansion (CTE) of ?1.15×10?6/° C. at 25° C. to 600° C.

Abstract: Preparation methods of a high modulus carbon fiber (HMCF) and a precursor (mesophase pitch (MP)) thereof are provided. The preparation method of MP includes: separating components with a molecular weight distribution (MWD) of 400 to 1,000 from a heavy oil raw material through size-exclusion chromatography (SEC); subjecting the components to ion-exchange chromatography (IEC) to obtain modified feedstock oil, where, the components are passed through macroporous cation-exchange and anion-exchange resins in sequence to remove acidic and alkaline components; and subjecting the modified feedstock oil to thermal polycondensation and carbonization to obtain high-quality MP with prominent spinnability. With high mesophase content, low softening point, low viscosity, and prominent meltability and spinnability, the obtained MP is a high-quality raw material for preparing HMCFs. The obtained MP can be subjected to melt spinning, pre-oxidation, carbonization, and graphitization to obtain an MP-based HMCF.

Abstract: The invention provided a method for preparing a bacterial polysaccharide-modified recombinant fusion protein and use of the bacterial polysaccharide-modified recombinant fusion protein. The method comprises: co-expressing a recombinant fusion protein and the Neisseria meningitidis O-oligosaccharyltransferase PglL in an O-antigen ligase gene-defective bacterium, and linking a polysaccharides endogenous or exogenous for the bacterium to the recombinant fusion protein by the O-oligosaccharyltransferase PglL, to obtain the bacterial polysaccharide-modified recombinant fusion protein. The protein can be used for preparing antibodies against bacterial polysaccharides and vaccines.

Abstract: The present invention discloses a Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.

Abstract: The present invention discloses a Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.

Abstract: A computer system supports a protocol to process directional navigation inputs to a host application and its component, to manage which component is currently active to receive input events. A first component determines whether to transfer focus to a second component. The first component initiates the transfer by sending a request to the second component. Further input events are queued. The second component processes the request to determine how to transfer focus within the second component. The second component indicates to the operating system how focus has been transferred. The operating system updates information to reflect the changes in state of the components, and informs the host and component that the state has been updated. Queued input events then can be released for processing according to the changed focus. Where the components are separate, independent processes, the protocol can be implemented through inter-process communication techniques.

Abstract: The invention provided a method for preparing a bacterial polysaccharide-modified recombinant fusion protein and use of the bacterial polysaccharide-modified recombinant fusion protein. The method comprises: co-expressing a recombinant fusion protein and the Neisseria meningitidis O-oligosaccharyltransferase PglL in an O-antigen ligase gene-defective bacterium, and linking a polysaccharides endogenous or exogenous for the bacterium to the recombinant fusion protein by the O-oligosaccharyltransferase PglL, to obtain the bacterial polysaccharide-modified recombinant fusion protein. The protein can be used for preparing antibodies against bacterial polysaccharides and vaccines.

Abstract: A computer system supports a protocol to process directional navigation inputs to a host application and its component, to manage which component is currently active to receive input events. A first component determines whether to transfer focus to a second component. The first component initiates the transfer by sending a request to the second component. Further input events are queued. The second component processes the request to determine how to transfer focus within the second component. The second component indicates to the operating system how focus has been transferred. The operating system updates information to reflect the changes in state of the components, and informs the host and component that the state has been updated. Queued input events then can be released for processing according to the changed focus. Where the components are separate, independent processes, the protocol can be implemented through inter-process communication techniques.

Abstract: A facility for processing textual input generated with a user input device described. In one example facility, the facility stores the textual input in a first data structure contained in the address space of a first process. The facility synchronizes contents of the first data structure to a second data structure contained in the address space of a second process distinct from the first process, an application executing in the second process being configured to consume textual input synchronized to the second data structure.

Abstract: The present invention discloses a Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.