Patents by Inventor Xin He

Xin He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12383581
    Abstract: The present invention includes compositions and methods for treating AML utilizing bispecific CARs. In certain aspects, the invention includes a bispecific split CAR which binds CD13 and TIM-3 on AML cells.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: August 12, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Xianxin Hua, Xin He, Xuyao Zhang
  • Patent number: 12371421
    Abstract: The present invention relates to solid forms of the poly(ADP-ribose) polymerase 7 (PARP7) inhibitor 5-[[(2S)-1-(3-oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propoxy)propan-2-yl]amino]-4-(trifluoromethyl)-2,3-dihydropyridazin-3-one, and salts thereof, including methods of preparation thereof, where the inhibitor is useful in the treatment of cancer.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: July 29, 2025
    Assignee: Ribon Therapeutics, Inc.
    Inventors: Melissa Marie Vasbinder, Laurie B. Schenkel, Kerren Kalai Swinger, Kevin Wayne Kuntz, Jun Xu, Meng Jiang, Xin He
  • Publication number: 20250232780
    Abstract: Devices and techniques are generally described for audio-based entity resolution. In various examples, first audio data representing speech comprising a mention of a first entity may be received. In some examples, first embedding data representing the first audio data may be received. Second embedding data representing the first entity may be determined. A first modified embedding may be generated using a first attention mechanism to compare the first embedding data to the second embedding data. In some examples, a determination may be made that the first audio data includes a mention of the first entity.
    Type: Application
    Filed: November 3, 2023
    Publication date: July 17, 2025
    Inventors: Xin He, Jiyang Wang, Xiaozhou Joey Zhou, Helian Feng, Ali Kebarighotbi, Kangrui Ruan
  • Patent number: 12337197
    Abstract: An automatic positioning device for helical tomotherapy plan verification is provided. The device includes a base located on a treatment bed of helical tomotherapy equipment, a lifting platform fixedly connected to a top of the base, a three-dimensional verification phantom fixedly connected to other ends of the two support rods, and an early warning component. A bearing platform is fixedly connected to a top of the lifting platform, a moving platform is arranged on the bearing platform, and ends of two support rods are fixedly connected to a side, close to the treatment bed, of the moving platform. The three-dimensional verification phantom extends into a treatment aperture through the moving platform. The early warning component includes two early warning pieces respectively arranged on the two support rods.
    Type: Grant
    Filed: March 29, 2025
    Date of Patent: June 24, 2025
    Assignee: Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University
    Inventors: Guoqian Zhang, Xin He, Shuxu Zhang, Linjing Wang, Shuyu Wu, Yuliang Liao, Lu Zhou, Huijun Li, Lu Yang, Ruihao Wang, Liangqian Gou
  • Patent number: 12332150
    Abstract: Disclosed are a ventilation test device and method for plastic parts of a coffee machine. The device includes a device body, a detection assembly on a top of the device body, gas delivery pipes on a top of the detection assembly, electric telescopic columns, and a pressing plate on tops of telescopic ends of the electric telescopic columns. Circular holes are formed in the pressing plate, telescopic rings are fixedly mounted at a bottom of the pressing plate, and the telescopic rings are located around peripheries of the circular holes. Downstream devices for identifying ventilation types are arranged inside the gas delivery pipes, annular inclined plates are arranged on the pressing plate, the annular inclined plates are distributed around peripheries of tops of the circular holes, and a U-shaped frame is hingedly connected to a top of an inclined plate in each of the annular inclined plates.
    Type: Grant
    Filed: March 11, 2025
    Date of Patent: June 17, 2025
    Assignee: Jiangsu Vnuo Certification and Testing Co., Ltd.
    Inventors: Pengliang Guo, Xin He, Lingquan Xiang, Dongqi Wang, Jianxin Hu
  • Publication number: 20250150024
    Abstract: A wave-resistant photovoltaic float used in a water environment, which includes multiple photovoltaic carriers and a photovoltaic module. The photovoltaic carrier includes an upper component and a lower component, which are integrally formed. The upper component is smaller than the lower component in terms of length and width. The lower component of the photovoltaic carrier is a flat-shaped floating structure. A hollow portion is provided in the middle of the lower component, and acts as a suction cup.
    Type: Application
    Filed: January 9, 2025
    Publication date: May 8, 2025
    Inventors: Yunyou XU, Wenbo LIU, Jingjing WANG, Xin HE, Wenjing QIN, Shuang ZHENG, Linhao LI
  • Publication number: 20250125788
    Abstract: A double-mode surface acoustic wave (SAW) filter includes a piezoelectric substrate, a pair of reflectors disposed on the piezoelectric substrate, and N input and output interdigital transducer tracks (IDT-tracks) disposed on the piezoelectric substrate and between the pair of reflectors, and alternately arranged along a longitudinal direction. Each IDT-track includes a pair of comb electrodes with a plurality of fingers, and adjacent fingers have opposite polarities. A total number of fingers in each IDT-track is an odd number greater than or equal to 3.
    Type: Application
    Filed: December 20, 2024
    Publication date: April 17, 2025
    Inventors: Xin HE, Duan FENG, Haiting GAO
  • Publication number: 20250086202
    Abstract: Systems, methods and computer-readable memory devices are provided for greater efficiency in the configuration of a database cluster for performing a query workload. A database cluster configuration system is provided that includes a database cluster comprising one or more compute resources configured to perform database queries. A query workload comprising a plurality of queries is received. An initial workload-level configuration is applied. For each query of the query workload, a query-level configuration is generated using a query configuration model corresponding to each query in a contextual Bayesian optimization with centroid learning while also leveraging the query plan for each executing query for query characterization and including application of virtual operators. Query events are collected and used to update the corresponding query configuration model. The workload-level configuration is updated based on the query events and cached for use during a subsequent execution of the workload.
    Type: Application
    Filed: September 13, 2023
    Publication date: March 13, 2025
    Inventors: Yiwen ZHU, Subramaniam Venkatraman KRISHNAN, Weihan TANG, Tengfei HUANG, Rui FANG, Rahul Kumar CHALLAPALLI, Mo LIU, Long TIAN, Karuna Sagar KRISHNA, Estera Zaneta KOT, Xin HE, Ashit R. GOSALIA, Dario Kikuchi BERNAL, Aditya LAKRA, Arshdeep SEKHON, Sule KAHRAMAN, Carlo Aldo CURINO, Brian Paul KROTH, Rathijit SEN, Andreas Christian MUELLER, Shaily Jignesh FOZDAR, Dhruv Harendra RELWANI, Xiang LI, Sergiy MATUSEVYCH
  • Publication number: 20250058275
    Abstract: A transformational energy efficient technology using ionic liquid (IL) to couple with monoethanolamine (MEA) for catalytic CO2 capture is disclosed. [EMmim+][NTF2?] based catalysts are rationally synthesized and used for CO2 capture with MEA. A catalytic CO2 capture mechanism is disclosed according to experimental and computational studies on the [EMmim+][NTF2?] for the reversible CO2 sorption and desorption.
    Type: Application
    Filed: November 1, 2024
    Publication date: February 20, 2025
    Applicants: University of Wyoming, Georgia Tech Research Corporation
    Inventors: Maohong Fan, Xiaowen Zhang, Yangyan Gao, Armistead G Russell, Xin He
  • Patent number: 12212615
    Abstract: An online meeting system begins the process of connecting a user to an online meeting when a request is received from a user to start or join the online meeting. In response to the request, a pre-meeting user interface (UI) is displayed having a user interface control which, when activated, enables transmission of audio and/or video data for the online meeting, and prior to activation of the control, connection parameters are shared with an online meeting service to preheat the meeting. In response to activation of the control, transmission of audio and/or video data for the online meeting is enabled.
    Type: Grant
    Filed: February 8, 2024
    Date of Patent: January 28, 2025
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Nagaswapna Bhamidipati, Xin He, Milica Jovanović, Artur Pawel Kania, Namendra Kumar, Rui Liang, Yue Li, Joel Harodi Marquez Catano, Abhilash Chandrasekharan Nair, Gaurav Pancholi, Jindrich Parus, Martin Petrla, Denis Postu, Rama Krishan Prasad Satya Prakash, Kensaku Sueda, Balvinder Kaur Thind, Hao Xu
  • Publication number: 20240430315
    Abstract: An online meeting system begins the process of connecting a user to an online meeting when a request is received from a user to start or join the online meeting. In response to the request, a pre-meeting user interface (UI) is displayed having a user interface control which, when activated, enables transmission of audio and/or video data for the online meeting, and prior to activation of the control, connection parameters are shared with an online meeting service to preheat the meeting. In response to activation of the control, transmission of audio and/or video data for the online meeting is enabled.
    Type: Application
    Filed: September 9, 2024
    Publication date: December 26, 2024
    Applicant: Microsoft Technology Licensing, LLC
    Inventors: Nagaswapna BHAMIDIPATI, Xin HE, Milica JOVANOVIC, Artur Pawel KANIA, Namendra KUMAR, Rui LIANG, Yue LI, Joel Harodi MARQUEZ CATANO, Abhilash Chandrasekharan NAIR, Gaurav PANCHOLI, Jindrich PARUS, Martin PETRLA, Denis POSTU, Rama Krishan Prasad SATYA PRAKASH, Kensaku SUEDA, Balvinder Kaur THIND, Hao XU
  • Patent number: 12168202
    Abstract: A transformational energy efficient technology using ionic liquid (IL) to couple with monoethanolamine (MEA) for catalytic CO2 capture is disclosed. [EMmim+][NTF2?] based catalysts are rationally synthesized and used for CO2 capture with MEA. A catalytic CO2 capture mechanism is disclosed according to experimental and computational studies on the [EMmim+][NTF2?] for the reversible CO2 sorption and desorption.
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: December 17, 2024
    Assignees: University of Wyoming, Georgia Tech Research Corporation
    Inventors: Maohong Fan, Xiaowen Zhang, Yangyan Gao, Armistead G Russell, Xin He
  • Publication number: 20240297909
    Abstract: An online meeting system begins the process of connecting a user to an online meeting when a request is received from a user to start or join the online meeting. In response to the request, a pre-meeting user interface (UI) is displayed having a user interface control which, when activated, enables transmission of audio and/or video data for the online meeting, and prior to activation of the control, connection parameters are shared with an online meeting service to preheat the meeting. In response to activation of the control, transmission of audio and/or video data for the online meeting is enabled.
    Type: Application
    Filed: February 8, 2024
    Publication date: September 5, 2024
    Applicant: Microsoft Technology Licensing, LLC
    Inventors: Nagaswapna BHAMIDIPATI, Xin HE, Milica JOVANOVI?, Artur Pawel KANIA, Namendra KUMAR, Rui LIANG, Yue LI, Joel Harodi MARQUEZ CATANO, Abhilash Chandrasekharan NAIR, Gaurav PANCHOLI, Jindrich PARUS, Martin PETRLA, Denis POSTU, Rama Krishan Prasad SATYA PRAKASH, Kensaku SUEDA, Balvinder Kaur THIND, Hao XU
  • Publication number: 20240292566
    Abstract: A heat dissipation apparatus and electronic device are provided. The heat dissipation apparatus includes a first branch pipeline, capable of accommodating a heat dissipation medium and configured for dissipating heat for the first heating element; a second branch pipeline, capable of accommodating a heat dissipation medium and configured for dissipating heat for the second heating element; a connection pipeline, two ends of the connection pipeline being connected to the first branch pipeline and the second branch pipeline respectively; an output pipeline, connected to the connection pipeline; and a moving member, movably arranged in the connection pipeline and capable of moving toward the first branch pipeline side or the second branch pipeline side in the connection pipeline to adjust a communication area between the first branch pipeline the output pipeline and a communication area between the second branch pipeline and the output pipeline.
    Type: Application
    Filed: February 5, 2024
    Publication date: August 29, 2024
    Inventors: Fang LIU, Xin HE
  • Publication number: 20240274895
    Abstract: A method for making a battery sensor is provided. Firstly, when the surface layer of battery case is insulated, a circuit pattern layout is carried out on the surface layer of the battery case, wherein the circuit pattern layout includes a base circuit layout and a sensor layout; conductive lines are fabricated in the surface layer of the battery case based on the base circuit layout, wherein the pattern of the conductive lines is the same as the circuit pattern; and sensors are fabricated in the surface layer of the battery case based on the sensor layout, wherein the sensors are the same as the sensor layout diagram.
    Type: Application
    Filed: April 21, 2022
    Publication date: August 15, 2024
    Inventor: Xin HE
  • Publication number: 20240234441
    Abstract: A display substrate and a display apparatus provided by the present disclosure include a plurality of pixels arranged in an array, where each of the pixels includes a plurality of sub-pixels, each of the sub-pixels includes a first domain area and a second domain area, and the first domain area and the second domain area each has at least two orientations; a plurality of data lines, where each of the data lines is electrically connected with first domain areas and second domain areas of a same column of sub-pixels; and a plurality of discharge wires, where each of the discharge wires is electrically connected with the second domain areas of the same column of the sub-pixels, and the discharge wires are configured for providing at least two direct current signals to two adjacent columns of pixels.
    Type: Application
    Filed: March 22, 2024
    Publication date: July 11, 2024
    Inventors: Yong LIU, Wu WANG, Yanping LIAO, Zhangtao WANG, Mingzhi NAN, Xin HE, Xingkai FU
  • Publication number: 20240210282
    Abstract: A platform for testing the excavation resistance of a small-sized backhoe excavator is provided. The testing platform comprises a bucket, a mechanical arm device, a measuring device, a workbench frame, and a control device. The bucket is hinged to the mechanical arm device, which is fixed on the workbench frame; the control device is electrically connected to the measuring device, data acquired by the measuring device is used to construct a force balance equation, and through force analysis, excavation resistance is obtained.
    Type: Application
    Filed: December 26, 2023
    Publication date: June 27, 2024
    Applicant: Guangxi University of Science and Technology
    Inventors: Bing LI, Wubin XU, Dengsheng CAI, Jinquan SUN, Xin HE
  • Patent number: 12006929
    Abstract: A multi-plunger coordinated gas lift liquid drainage system and liquid drainage method thereof, the system operates in a reciprocating manner. A large-section liquid column and a gas column within a tubing is divided into multiple units of liquid columns, plungers and gas columns by a plurality of plungers; the units form a series connection, and the plungers in the tubing move up and down respectively to transfer the liquid load cooperatively. A liquid is drained from a wellbore step by step, and the pressure formed by a small section of liquid column disappears each time a small section of liquid column is drained. The pressure of each stage of gas column thereunder is reduced, and the gas columns are expanded step by step.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: June 11, 2024
    Assignee: Sichuan Haichelifu Oil and Gas Engineering Technology Service Co., Ltd
    Inventor: Xin He
  • Publication number: 20240157295
    Abstract: A transformational energy efficient technology using ionic liquid (IL) to couple with monoethanolamine (MEA) for catalytic CO2 capture is disclosed. [EMmim+][NTF2?] based catalysts are rationally synthesized and used for CO2 capture with MEA. A catalytic CO2 capture mechanism is disclosed according to experimental and computational studies on the [EMmim+][NTF2?] for the reversible CO2 sorption and desorption.
    Type: Application
    Filed: October 24, 2022
    Publication date: May 16, 2024
    Applicants: University of Wyoming, Georgia Tech Research Corporation
    Inventors: Maohong Fan, Xiaowen Zhang, Yangyan Gao, Armistead G. Russell, Xin He
  • Patent number: D1074343
    Type: Grant
    Filed: July 26, 2023
    Date of Patent: May 13, 2025
    Inventor: Xin He