Abstract: A method and system provide an ophthalmic device. The ophthalmic device includes an ophthalmic lens having anterior surface, a posterior surface and at least one diffractive structure including a plurality of zones. The at least one diffractive structure is for at least one of the anterior surface and the posterior surface. Each zone includes at least one echelette having a least one step height. The step height(s) are individually optimized for each zone. To compensate chromatic aberration of eye from distance to a range of vision, a greater than 2? phase step height may be employed and the step height(s) folded by a phase, which is an integer multiple of two multiplied by ?. Hence chromatic aberration of eye may be compensated to improve vision from distance to near.

Abstract: An ophthalmic lens includes an optic with a first surface, a second surface, and a phase-shift structure having one or more phase-shift regions. A method for fabricating an ophthalmic lens includes designing an optic with a first surface, a second surface, and a phase-shift structure having one or more phase-shift regions. The phase-shift regions may be adapted to generate respective chromatic focal shifts such that an incident radiation in a respective wavelength range at least partially converges towards a respective selected wavelength. The method includes determining a chromatic aberration target for the optic and determining the quantity of the phase-shift regions meeting the chromatic aberration target. The optic is formed with the phase-shift regions having respective optimal heights obtained based in part on an overall interaction effect. The phase-shift structure may be adapted to increase a depth-of-focus of the optic in the direction of extension.

Abstract: This disclosure relates to new assay methods for analysis of RNA, e.g., from circulating tumor cells (CTCs), tumor-specific exosomes, or tumor-specific cell-free RNA, in a subject's blood sample to determine an expression level of one or more lineage markers in the blood sample, wherein the expression level of a specific one or more lineage markers is predictive of progression-free survival and overall survival for a specific anti-cancer treatment regimen in that subject.

Abstract: An ophthalmic lens defining an optical axis can include: a plurality of annular regions extending in a radial direction away from the optical axis, including a corresponding plurality of echelettes, wherein the plurality of echelettes forms an echelette profile, wherein each the echelette profile includes a staircase profile, wherein each echelette includes a staircase step, wherein, for each staircase step, there are M phase-shift units arranged vertically, wherein M is an integer, wherein each phase-shift unit has a phase height configured to shift the phase of a reference frequency of light by approximately N*2*?, where N is an integer, and wherein the staircase profile forms an irregular staircase.

Abstract: A method and system provide an ophthalmic device. The ophthalmic device includes an ophthalmic lens having anterior surface, a posterior surface and at least one diffractive structure including a plurality of zones. The at least one diffractive structure is for at least one of the anterior surface and the posterior surface. Each zone includes at least one echelette having a least one step height. The step height(s) are individually optimized for each zone. To compensate chromatic aberration of eye from distance to a range of vision, a greater than 2? phase step height may be employed and the step height(s) folded by a phase, which is an integer multiple of two multiplied by ?. Hence chromatic aberration of eye may be compensated to improve vision from distance to near.

Abstract: In certain embodiments, an ophthalmic lens includes an optic having an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface includes a first zone extending from the optical axis to a first radial boundary and a second zone extending from the first radial boundary to the edge of the optic. The first zone includes an inner region and an outer region separated by a phase shift feature, the phase shift comprising a ridge extending outwardly from the inner region and the outer region.

Abstract: A method and system provide an ophthalmic device. The ophthalmic device includes an ophthalmic lens having an anterior surface, a posterior surface, at least one diffractive structure and at least one base curvature. The at least one diffractive structure for provides a first spherical aberration for a first focus corresponding to at least a first focal length. The at least one base curvature provides a second spherical aberration for at least a second focus corresponding to at least a second focal length. The first spherical aberration and the second spherical aberration are provided such that the first focus has a first focus spherical aberration and the second focus has a second focus spherical aberration. The first focus spherical aberration is opposite in sign to the second focus spherical aberration.

Abstract: A voltage mode transmitter circuit includes a low-dropout (LDO) regulator and an output circuit. The LDO regulator generates a driving voltage. The output circuit generates an output signal, and includes: a termination resistor, transmitting the output signal; a data processing circuit, driven by the driving voltage and adjusting a level of a node according to first and second data signals; a pre-emphasis circuit, transmitting a supply voltage to the node according to a control signal to adjust a transition edge of the output signal; a voltage protection circuit, providing an overvoltage protection according to a bias voltage, and coupling the node to the termination resistor. The data processing circuit, the pre-emphasis circuit, and the voltage protection circuit include at least one transistor, and a highest level of the output signal is higher than a withstand voltage of the at least one transistor.

Abstract: An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature, a refractive region having the base curvature, and a diffractive region comprising a diffractive profile including a plurality of diffractive steps. At least a portion of the diffractive profile constitutes a combination of a base diffractive profile defining multiple foci for the ophthalmic lens and an achromatizing structure that reduces longitudinal chromatic aberrations.

Abstract: A method and system provide an ophthalmic device. The ophthalmic device includes an ophthalmic lens having an anterior surface, a posterior surface, at least one diffractive structure and at least one base curvature. The at least one diffractive structure for provides a first spherical aberration for a first focus corresponding to at least a first focal length. The at least one base curvature provides a second spherical aberration for at least a second focus corresponding to at least a second focal length. The first spherical aberration and the second spherical aberration are provided such that the first focus has a first focus spherical aberration and the second focus has a second focus spherical aberration. The first focus spherical aberration is opposite in sign to the second focus spherical aberration.

Abstract: A method for vehicle motion forecasting includes the following steps. A lane graph structure is generated according to a raw map data. Multiple occupancy flow graphs which are homogeneous to data format of the lane graph structure are established according to trajectory data of a plurality of vehicles in multiple consecutive frames and the lane graph structure. Multiple temporal edges between the occupancy flow graphs are established according to the trajectory data of the vehicles in the consecutive frames to construct a temporal occupancy flow graph. Feature aggregation is performed on the temporal occupancy flow graph to generate multiple updated node features, and a motion forecasting of an ego-vehicle is generated according to the updated node features.

Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3, A, M, W and Q are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Abstract: Methods, system, and computer storage media are provided for multi-modal localization. Input data comprising two modalities, such as image data and corresponding text or audio data, may be received. A phrase may be extracted from the text or audio data, and a neural network system may be utilized to spatially and temporally localize the phrase within the image data. The neural network system may include a plurality of cross-modal attention layers that each compare features across the first and second modalities without comparing features of the same modality. Using the cross-modal attention layers, a region or subset of pixels within one or more frames of the image data may be identified as corresponding to the phrase, and a localization indicator may be presented for display with the image data. Embodiments may also include unsupervised training of the neural network system.

Abstract: A multifocal ophthalmic lens includes an ophthalmic lens and a diffractive element. The ophthalmic lens has a base curvature corresponding to a base power. The diffractive element produces constructive interference in at least four consecutive diffractive orders corresponding a range of vision between near and distance vision. The constructive interference produces a near focus, a distance focus corresponding to the base power of the ophthalmic lens, and an intermediate focus between the near focus and the distance focus. A diffraction efficiency of at least one of the diffractive orders is suppressed to less than ten percent.

Abstract: An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature, a refractive region having the base curvature, and a diffractive region comprising a diffractive profile including a plurality of diffractive steps. At least a portion of the diffractive profile constitutes a combination of a base diffractive profile defining multiple foci for the ophthalmic lens and an achromatizing structure that reduces longitudinal chromatic aberrations.

Abstract: Disclosed in the present invention is a method for preparing a tertiary amine by using a secondary amine as a raw material. The method comprises a step of reacting a secondary amine that serves as a raw material with an acid to generate a proton-type ionic liquid, and a step of reacting the proton-type ionic liquid with an aldehyde under the action of a reducing agent to generate a tertiary amine. The secondary amine is an aliphatic secondary amine and/or an aromatic secondary amine and/or a cyclic secondary amine; the acid is selected from one of or a combination of several of an organic carboxylic acid and an inorganic acid; the aldehyde is a monoaldehyde, a dialdehyde or an aldehyde polymer; and the reducing agent is selected from one of or a combination of several of formic acid, sodium formate, oxalic acid, sodium oxalate and triphenylsilane.

Abstract: A method and system provide an ophthalmic device. The ophthalmic device includes an ophthalmic lens having anterior surface, a posterior surface and at least one diffractive structure including a plurality of zones. The at least one diffractive structure is for at least one of the anterior surface and the posterior surface. Each zone includes at least one echelette having a least one step height. The step height(s) are individually optimized for each zone. To compensate chromatic aberration of eye from distance to a range of vision, a greater than 2? phase step height may be employed and the step height(s) folded by a phase, which is an integer multiple of two multiplied by ?. Hence chromatic aberration of eye may be compensated to improve vision from distance to near.

Abstract: Disclosed are techniques for identity verification. In one aspect, the method includes determining whether a user account has the identity data; obtaining from a blockchain the hash value of the identity data signed with the private key if it is determined that the user account has the identity data; using the public key to verify the hash value of the identity data signed with the private key to obtain a decrypted hash value of the identity data; and comparing the decrypted hash value of the identity data with the hash value of the identity data stored in the database to generate an identity verification result.

Abstract: An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature and a plurality of morphed sinusoidal phase shift structures. The base curvature may correspond to a base optical power of the ophthalmic lens, and the morphed sinusoidal phase shift structures may be configured to extend depth of focus of the ophthalmic lens at intermediate or near viewing distances.

Abstract: This disclosure relates to new assay methods for analysis of circulating tumor cells (CTCs) in blood samples for detection, e.g., early detection, and/or monitoring of disease, e.g., cancer. The methods provide ultra-high sensitivity and specificity, and include the use of microfluidic isolation of CTCs and digital detection of RNA derived from the CTCs.