Abstract: A method, system and computer-usable medium are disclosed for operating an endpoint court at an endpoint device. Certain embodiments include a computer-implemented method for operating an endpoint core at an endpoint device, the method including: receiving an event subscription request from an endpoint agent over a message bus; and managing communication of events for processing by the endpoint agent based on the event subscription request so that events to which the endpoint agent has subscribed are selectively processed at the endpoint agent. Certain embodiments may include corresponding stand-alone and/or network computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform one or more of these actions.

Abstract: An unloading mechanism and an unloading device with double food stirring trays, the unloading mechanism with double food stirring trays comprises a food stirring device and a driving device, and the food stirring device comprises a rotating shaft, an upper food stirring tray and a lower food stirring tray; the upper food stirring tray comprises upper food stirring plates, the lower food stirring tray comprises lower food stirring plates, the number of the lower food stirring plates is larger than that of the upper food stirring plates; the outer wall of the rotating shaft is provided with an installation groove, and the lower food stirring plates are provided with installation strips matched with the installation groove; and the unloading device comprises a food storage bin, a transition bin and the unloading mechanism with double food stirring trays.

Abstract: Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as “c-Abl”). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an allosteric site and inhibit its activity in various pathways. The compound embodiments also are capable of crossing the blood brain barrier and therefore are useful in inhibiting c-Abl activity as it affects pathways and/or proteins in the brain. The compound embodiments described herein are effective therapeutic agents for treating diseases involving c-Abl, such as cancers, motor neuron diseases, and neurodegenerative diseases. Also disclosed herein are embodiments of methods for making and using the c-Abl inhibitory compound embodiments.

Abstract: The disclosure of a compound of Formula (I) or a pharmaceutically acceptable salt thereof (I) The variables W, R1, R2, R3, and R4 are defined in the disclosure. The disclosure provides a compound or salt of Formula (I) together with a pharmaceutically acceptable carrier. The disclosure also provides methods of treating a patient for Parkinson's disease and related syndromes, dyskinesia, especially dyskinesias secondary to treating Parkinson's disease with L-DOPA, neurodegenerative disorders such as Alzheimer's disease and dementia, Huntington's disease, restless legs syndrome, bipolar disorder and depression, schizophrenia, cognitive dysfunction, or substance use disorders, the methods comprising administering a compound of Formula I or salt thereof to the patient. The disclosure provides combination methods of treatment in which the compound of Formula (I) is administered to the patient together with one or more additional active agents.

Abstract: The present invention relates to a support device used in weighing coal of a raw coal bunker in a thermal power plant and a weighable raw coal bunker. The support device includes a base, a positioning sleeve, an upper support and a weighing sensor, a sensor groove being provided in the middle of the base, the weighing sensor being arranged in the sensor groove, the positioning sleeve being arranged on the base in a covering mode, a positioning hole being provided in the middle of the positioning sleeve, the upper support being movably inserted in the positioning hole, and a bottom surface of the upper support penetrating the positioning hole to abut against a top surface of the weighing sensor. The raw coal bunker uses the support device. Compared with the prior art, the present invention effectively meets the weighing requirement of the raw coal bunker.

Abstract: An electrical connector includes a body and multiple conductive terminals. The body has an insertion slot. Each conductive terminal has a contact portion entering the insertion slot and a conductive portion passing downward beyond a bottom surface of the body. Each side of the insertion slot has first terminal groups and second terminal groups. The conductive portions of each first terminal group are located away from the insertion slot relative to the conductive portions of each second terminal group. The conductive portions are provided in four rows in a lateral direction. The conductive terminals include signal terminals and ground terminals. The circuit board has an adjusting hole and four rows of connecting points corresponding to the conductive portions. Each row of the connecting points include multiple signal connecting points and multiple ground connecting points. The adjusting hole is located between two signal connecting points in two adjacent rows.

Abstract: Compounds of Formula I, Formula II, and Formula III and the pharmaceutically acceptable salts thereof are disclosed. The variables X, a, b, c, d, R1-4, R10-15 and R17-22 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving M2 phenotype of macrophages. Pharmaceutical compositions containing compounds of Formula I or Formula II or Formula III and methods of treatment comprising administering compounds of Formula I and Formula II and Formula III are also disclosed.

Abstract: A memory management method is provided according to the invention. The method includes: reading a physical unit and updating a read count of the physical unit; scanning the physical unit if the updated read count is not less than a read count threshold; and adjusting the read count threshold according to the read count and a read error bit. Therefore, a data unit that needs to be scanned can be determined to reduce unnecessary data scanning.

Abstract: The present invention relates to the field of virology. More specifically, the present invention provides methods and compositions useful for prevention and treatment of human cytomegalovirus (CMV). In one embodiment, a pharmaceutical composition comprises (a) emetine or a derivative thereof; (b) a human cytomegalovirus (HCMV) drug; and (c) a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical composition further comprises an adjuvant. In a specific embodiment, the HCMV drug is ganciclovir. In such embodiments, emetine is present at about 1/10 to about 1/100 the normal dosage for amebiasis.

Abstract: Unknown and reference signatures are accessed. The unknown and reference signatures indicate patterns that correspond to known threats to resources (such as computer systems and/or computer networks) in a computer environment and comprise a multitude of descriptive elements having information describing different aspects of a corresponding signature. A set of similarity measures is created of the unknown and reference signatures from different perspectives, each perspective corresponding to a descriptive element. The set of similarity measures are integrated to generate an overall similarity metric. The overall similarity metric is used to find appropriate categories in the reference signatures into which the unknown signatures should be placed. The unknown signatures are placed into the appropriate categories to create a mapping from the unknown signatures to the reference signatures.

Abstract: Provided is a coal-containing wastewater spraying device for dust suppression during coal conveying, including a motor, a gland, a body seat, and an accelerator. The body seat includes a funnel-shaped cover, a first disc and a plurality of crushing plates. The accelerator includes a circular second disc. The end of an output shaft of the motor passes through the first disc to connect with the second disc. The cover is provided with a water retaining ring between the first disc and the second disc along its axial direction. The cover, the first disc, the second disc and the water retaining ring form a water inlet space.

Abstract: Disclosed herein is a system for facilitating managing incidents occurring in areas monitored by low data-rate monitoring devices using the low data-rate monitoring devices, in accordance with some embodiments. Accordingly, the system comprises a processor, a device server, and a data visualization device. Further, a camera of a low data-rate monitoring device is configured for capturing video of an area. Further, the processor comprises a machine learning (ML) hardware accelerator configured for performing machine learning processing of the video. Further, the processor is configured for generating processed data. Further, the device server is configured for receiving the processed data based on the transmitting of the processed data from a low data-rate transceiver of the low data-rate monitoring device and transmitting a notification to a device.

Abstract: An optical proximity correction (OPC) operation method and an OPC operation device are provided. The OPC operation method includes the following steps. A mask layout is obtained. If the mask layout contains at least one defect hotspot, at least one partial area pattern is extracted from the mask layout according to the at least defect hotspot. A machine learning model is used to analyze the local area pattern to obtain at least one OPC strategy. The OPC strategy is implemented to correct the mask layout.

Abstract: Provided is an annular rotatable air supply device for a coal storage Eurosilo. The device includes an air duct rotatable ring and an air duct fixing ring. The air duct rotatable ring is fixedly connected with a central revolving platform of the Eurosilo by a second support bracket, the air duct fixing ring is fixedly connected with a top trestle of the Eurosilo by a first support bracket, and the air duct rotatable ring and the air duct fixing ring are arranged coaxially with the central axis of rotation of the Eurosilo. The air duct air duct rotatable ring is sealingly connected with the air duct fixing ring via a sealing assembly, and the air duct rotatable ring and the air duct fixing ring form an annular air duct therebetween.

Abstract: The present invention relates to a support device used in weighing coal of a raw coal bunker in a thermal power plant and a weighable raw coal bunker. The support device includes a base, a positioning sleeve, an upper support and a weighing sensor, a sensor groove being provided in the middle of the base, the weighing sensor being arranged in the sensor groove, the positioning sleeve being arranged on the base in a covering mode, a positioning hole being provided in the middle of the positioning sleeve, the upper support being movably inserted in the positioning hole, and a bottom surface of the upper support penetrating the positioning hole to abut against a top surface of the weighing sensor. The raw coal bunker uses the support device. Compared with the prior art, the present invention effectively meets the weighing requirement of the raw coal bunker.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a phenyl-sulfonic amide (or similar) structure which function as agonists of mucolipin 1 (ML1), and their use as therapeutics for the treatment of Duchenne muscular dystrophy (DMD) and related disorders.

Abstract: The present invention relates to a ventilating and blanking device for a coal storage Eurosilo. The ventilating and blanking device includes a top blanking pipe, an axial flow fan and a baffle door, the top blanking pipe including a first pipeline and a second pipeline, an air supply pipe is connected to a side wall of the second pipeline, and the baffle door is connected to a driving mechanism; during blanking, the driving mechanism drives the baffle door so as to make the baffle door close the air supply pipe and the axial flow fan is shut off; and during ventilation, the driving mechanism drives the baffle door so as to make the baffle door close the first pipeline, and the axial flow fan is turned on. Compared with the prior art, the present invention has the advantages of ventilation efficiency, good ventilation effect, etc.