Patents by Inventor Xin-Hua Feng

Xin-Hua Feng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CSPG4-TARGETING HUMANIZED CHIMERIC ANTIGEN RECEPTOR, IMMUNE EFFECTOR CELL EXPRESSING CHIMERIC ANTIGEN RECEPTOR, AND APPLICATIONS THEREOF
    Publication number: 20230357355
    Abstract: Related are a CSPG4-targeting humanized chimeric antigen receptor and applications thereof, comprising a humanized anti-CSPG4 binding domain, a hinge region, a transmembrane domain, and a signal transduction domain. The anti-CSPG4 binding domain comprises an anti-CSPG4 antibody or antigen binding part. Related are an immune effector cell expressing the CSPG4-targeting humanized chimeric antigen receptor and applications of the cell.
    Type: Application
    Filed: September 23, 2021
    Publication date: November 9, 2023
    Applicant: BOYUAN RUNSHENG PHARMA (HANGZHOU) CO., LTD.
    Inventors: Chuang SUN, Xin-Hua FENG, Bin ZHAO
  • CHIMERIC ANTIGEN RECEPTOR AND IMMUNE EFFECTOR CELL EXPRESSING CHIMERIC ANTIGEN RECEPTOR
    Publication number: 20230055426
    Abstract: Provided are a chimeric antigen receptor capable of targeting B7-H3, a nucleic acid molecule encoding the chimeric antigen receptor, a nucleic acid construct comprising the nucleic acid molecule, an immune effector cell expressing the chimeric antigen receptor, and use thereof. The chimeric antigen receptor comprises an anti-B7-H3 binding domain, a hinge region, a transmembrane domain and a signal transduction domain. Further provided are a composition and a method for diagnosing, treating or preventing tumors that express B7-H3.
    Type: Application
    Filed: August 6, 2020
    Publication date: February 23, 2023
    Inventors: Chuang Sun, Xin-Hua Feng, Bin Zhao
  • Gene expression suppression agents
    Patent number: 7964714
    Abstract: A method is provided for making gene suppression agents to be used in eukaryotic cells by using a recombinant DNA construct containing at least one transcriptional unit compromising a transcriptional promoter, a template sequence for making a RNA molecule, and a transcriptional terminator. Mechanisms of the RNA mediated gene suppression include, but are not limited to, RNA interferences (RNAi). The use of the agents as tools for biomedical research as well as medicinal products is also disclosed.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: June 21, 2011
    Assignee: Potomac Pharmaceuticals Inc.
    Inventors: Yingxian Xiao, Xin-Hua Feng
  • Gene expression suppression agents
    Publication number: 20070105795
    Abstract: A method is provided for making gene suppression agents to be used in eukaryotic cells by using a recombinant DNA construct containing at least one transcriptional unit compromising a transcriptional promoter, a template sequence for making a RNA molecule, and a transcriptional terminator. Mechanisms of the RNA mediated gene suppression include, but not limited to, RNA interferences (RNAi). The use of the agents as tools for biomedical research as well as medicinal products is also disclosed.
    Type: Application
    Filed: May 12, 2003
    Publication date: May 10, 2007
    Applicant: POTOMAC PHARMACEUTICALS, INC.
    Inventors: Yingxian Xiao, Xin-Hua Feng