Patents by Inventor Xin-Jie Chu

Xin-Jie Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted hydantoins
    Publication number: 20060041146
    Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 23, 2006
    Inventors: Xin-Jie Chu, Nader Fotouhi, Nicholas Huby, Norman Kong, Lee McDermott, John Moliterni, Zhuming Zhang
  • 4-Aminothiazole derivatives
    Publication number: 20060014958
    Abstract: Novel 4-aminothiazole derivatives are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminothiazole derivatives.
    Type: Application
    Filed: June 29, 2005
    Publication date: January 19, 2006
    Inventors: Li Chen, Xin-Jie Chu, Allen Lovey, Chunlin Zhao
  • 2,6-Diaminopyridine derivatives
    Publication number: 20060014708
    Abstract: Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.
    Type: Application
    Filed: June 24, 2005
    Publication date: January 19, 2006
    Inventors: David Bartkovitz, Xin-Jie Chu, Allen Lovey, Peter Wovkulich
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20050239711
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: June 22, 2005
    Publication date: October 27, 2005
    Inventors: Li Chen, Adrian Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Yagaloff
  • Diaminothiazoles
    Patent number: 6818663
    Abstract: The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung and colon and prostate tumors.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: November 16, 2004
    Assignee: Hoffmann-La Roches
    Inventors: Xin-Jie Chu, Qingjie Ding, Nan Jiang, Kyungjin Kim, Allen John Lovey, Warren William McComas, John Guifoyle Mullin, Jr., Jefferson Wright Tilley
  • 4-aminopyrimidine-5-one derivatives
    Publication number: 20040162303
    Abstract: Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminopyrimidine-5-one derivatives.
    Type: Application
    Filed: February 2, 2004
    Publication date: August 19, 2004
    Inventors: David Joseph Bartkovitz, Xin-Jie Chu, Qingjie Ding, Nan Jiang, Allen John Lovey, John Anthony Moliterni, John Guilfoyle Mullin, Binh Thanh Vu, Peter Michael Wovkulich
  • DIAMINOTHIAZOLES
    Publication number: 20040006058
    Abstract: The present invention is directed to novel diaminothiazoles of formula 1
    Type: Application
    Filed: May 5, 2003
    Publication date: January 8, 2004
    Inventors: Xin-Jie Chu, Qingjie Ding, Nan Jiang, Kyungjin Kim, Allen John Lovey, Warren William McComas, John Guilfoyle Mullin, Jefferson Wright Tilley
  • Selective linear peptides with melanocor tin-4 receptor (MC4-R) agonist activity
    Publication number: 20030229200
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: May 9, 2003
    Publication date: December 11, 2003
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Patent number: 6600015
    Abstract: Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: July 29, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20020143141
    Abstract: Peptides cyclized via disulfide or lactam bridges having melanocortin-4 receptor (MC4-R) agonist activity useful for treatment of obesity.
    Type: Application
    Filed: August 27, 2001
    Publication date: October 3, 2002
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Yao Wang, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20010056179
    Abstract: Peptides of formulae I, II and III selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: March 19, 2001
    Publication date: December 27, 2001
    Inventors: Li Chen, Adrian W. Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith A. Yagaloff