Abstract: Provided herein are anaplastic lymphoma kinase (ALK) fusion nucleic acid molecules and polypeptides, methods related to detecting ALK fusion nucleic acid molecules and polypeptides in cancer, as well as methods of treatment and uses related thereto. Detection of an ALK fusion nucleic acid molecule or polypeptide can be used to identify individuals that may benefit from treatment with an anti-cancer therapy.

Abstract: Provided herein are conjugate molecules comprising an antibody or antibody fragment capable of binding polyclonal immnunoglobulins within a subject. Such conjugates are useful for recruiting immune cells of the subject to one or more cell types that are targeted by the conjugate. Also provided herein are compositions comprising the conjugates, including pharmaceutical compositions that may be administered to a subject, for such a purpose as to treat or prevent a disease.

Abstract: The present disclosure discloses a chemical shift coded imaging method based on a transition region and regional iterative phasor extraction. Acquiring an initial image, and determining an initial phasor solution of the transition region based on the initial image; performing regional iterative phasor extraction in at least two set directions by taking the initial phasor solution as initial information, and obtaining a target phasor solution based on a regional iterative phasor extraction result corresponding to each set direction; and determining a first chemical composition signal and a second chemical composition signal based on the target phasor solution, and performing chemical shift coded imaging based on the first chemical composition signal and/or the second chemical composition signal.

Abstract: A sealing device, comprising includes a sealing ring including a sealing lip composed of an insulating elastic material for forming dynamic sealing with respect to a conductive component; a support body fixed on the sealing ring along the circumferential direction of the sealing ring, and a first detection unit comprising two first support bodies in the support body, first cables respectively electrically connected to the corresponding first support bodies, and a loop detection device electrically connected to the first cables, wherein the first support bodies are arranged at the sealing ring such that radial ends of the first support bodies close to the conductive component are covered with the insulating elastic material at the sealing lip and can directly contact the conductive component after the sealing lip is worn. The two first support bodies, the conductive component, the loop detection device, and the first cables jointly form a communication loop.

Abstract: Provided is a method of dynamically generating a personalized knowledge graph based on prompt learning. The method includes the following steps: classifying a textbook difficulty to obtain textbook difficulty prompt words; extracting a learning target to obtain learning target prompt words; evaluating the learning ability of students to obtain a level of the learning ability of students; and generating a dynamic personalized knowledge graph according to prompt words selected by students, evaluation results of the learning ability and a set prompt mapping rule. The method evaluates the learning ability, and selects a course learning difficulty and a course learning target as required. The above steps are combined with subjectivity and passivity to integrally and dynamically generate personalized courses. Each class can make a selection, so as to meet ever-changing learning needs of the student.

Abstract: The present invention belongs to the technical field of lightning protection of power transmission lines, and in particular, relates to a method for limiting lightning overvoltage of a direct-current power transmission line. By means of using operation date of a line itself, lightning current monitoring data, and parameters of an environment where the line is located, a line dynamic operation function curve and a line lightning-protection performance function curve are both corrected to obtain a more realistic voltage difference, thus achieving reliable protection actions and state sensing of a lightning arrester on the line. An apparatus for limiting a lightning overvoltage of a direct-current power transmission line is further provided in the present invention to cooperate with the implementation of the method.

Abstract: A light-emitting device includes a semiconductor epitaxial unit having a first surface and a second surface that are opposite to each other, and including a first semiconductor layer, an active layer, and a second semiconductor layer that are disposed sequentially in such order in a direction from the first surface to the second surface. The active layer includes a quantum well structure that has n periodic units, each of which includes a well layer and a barrier layer that are sequentially disposed. The second semiconductor layer includes a cladding layer and a current spreading layer. A ratio of a thickness of the current spreading layer to a current density of the light-emitting device ranges from 0.6 to 4. A light-emitting apparatus is also provided in the disclosure.

Abstract: In various examples, sensor data representative of an image of a field of view of a vehicle sensor may be received and the sensor data may be applied to a machine learning model. The machine learning model may compute a segmentation mask representative of portions of the image corresponding to lane markings of the driving surface of the vehicle. Analysis of the segmentation mask may be performed to determine lane marking types, and lane boundaries may be generated by performing curve fitting on the lane markings corresponding to each of the lane marking types. The data representative of the lane boundaries may then be sent to a component of the vehicle for use in navigating the vehicle through the driving surface.

Abstract: A light-emitting diode includes a semiconductor epitaxial structure which includes a first semiconductor layer, an active layer, and a second semiconductor layer that are stacked in sequence. The second semiconductor layer includes a current spreading layer, which includes a first doped layer doped with a first p-type impurity, a second doped layer doped with the first p-type impurity and a second p-type impurity, and a third doped layer doped with the second p-type impurity. A concentration of the first p-type impurity in the first doped layer is less than or equal to a concentration of the first p-type impurity in the second doped layer. A concentration of the second p-type impurity in the third doped layer is greater than a concentration of the second p-type impurity in the second doped layer. A light-emitting device including the aforesaid light-emitting diode is also provided.

Abstract: Provided are a hydantoin compound as represented by formula (I) or a pharmaceutically acceptable salt thereof and the medical use thereof. The compound has a strong agonistic action on PPAR? and PPAR?, has a good selectivity to PPAR?, and has good pharmacokinetic properties. The compound or a pharmaceutically acceptable salt, prodrug, deuterated compound or solvate thereof can be used for preparing a PPAR?/? dual agonist, and is used for preparing a drug for preventing or treating diseases mediated by PPAR? and/or PPAR?.

Abstract: This disclosure discloses a multiplayer somatosensory system, method, and apparatus combining virtual and reality, and a medium, which belongs to the field of human-computer interaction. The system includes: a computer device, and a simulation carrier, n simulation firearms and a display apparatus; where the simulation carrier includes a driver's seat and n passenger seats; the display apparatus is configured to display a virtual environment picture and n aiming points provided by the computer device; and the computer device is configured to control a virtual carrier to change a driving direction in the virtual environment; control the virtual carrier to change a driving speed in the virtual environment; and shoot a virtual object aimed at an ith aiming point in the virtual environment in response to a shooting operation on an ith simulation firearm in the n simulation firearms.

Abstract: An encoding and decoding method are disclosed. The method includes: Each of multiple viewpoint bitstreams includes a first type bitstream and a second type bitstream; when a first image frame in a first type bitstream of a first viewpoint bitstream is played, receiving a switching request that indicates to play a second viewpoint bitstream; determining a first random access frame that is in a first type bitstream and/or a second type bitstream of the second viewpoint bitstream and has a play moment after and closest to the first image frame; decoding to obtain the first random access frame based on encoded data of the first random access frame in the second viewpoint bitstream, and decoding to obtain and play an image frame that is in the first type bitstream of the second viewpoint bitstream by using the first random access frame as a reference frame.

Abstract: A floating column spoiler structure, a floating column and a floating wind turbine are provided. The floating column spoiler structure includes multiple spoiler plates and lifting and unfolding assemblies connecting each of the spoiler plates and a column. Each of the lifting and unfolding assemblies includes a first connecting rod, a second connecting rod, a first gear and a second gear; a first end of the first connecting rod is rotatably connected with a first end of the second connecting rod, and each of the spoiler plates is arranged at the first end of the first connecting rod and the first end of the second connecting rod; a second end of the first connecting rod is rotatably connected with the first gear, and a second end of the second connecting rod is rotatably connected with the second gear.

Abstract: The present invention discloses a transfer method of thin wafer. For thin wafers with different thicknesses, in different transfer stages, a Bernoulli manipulator uses different gas flow rates, so that the problem of chipping of wafers during transfer is solved. Specifically, in a process of moving a wafer out of a wafer cassette, a Bernoulli manipulator uses a small gas flow rate, so as to reduce the suction force on the wafer and weaken warping deformation of the wafer, thereby reducing the risk of cracking or chipping in the process of moving the wafer out of the wafer cassette; after the wafer is moved out of the wafer cassette and in a process of transferring same to a processing chamber, the Bernoulli manipulator uses a large gas flow rate, so as to increase the suction force on the wafer, thereby ensuring the wafer can be stably suctioned on the Bernoulli manipulator during transfer, and avoiding wafer slipping.

Abstract: The present application provides a preparation method for biosynthesis of a human body structural material. A polypeptide has the amino acid sequence of SEQ ID NO. 4, 5 or 6. Recombinant type-VII humanized collagen prepared in the present application has high activity of promoting cell proliferation and does not produce an immune response when applied to a human body, and the preparation method therefor is novel and can obtain the recombinant type-VII humanized collagen on a large scale, and is widely applied in the preparation of human body structural materials.

Abstract: A display device including a display panel and a support layer is provided. The display panel has a light-transmitting area and a bonding area. The support layer includes a first support layer and a second support layer, where the first support layer has a first portion corresponding to the light-transmitting area, the second support layer has a second portion corresponding to the bonding area, and an optical phase retardation coefficient of the first portion is less than an optical phase retardation coefficient of the second portion.

Abstract: A temperature sensing system includes a plurality of resistive segments connected in electrical series. Each resistive segment defines a material different from a material of an adjacent resistive segment, and the plurality of resistive segments are joined at sensing junctions to define a plurality of sensing junctions along a length of the resistive segments. A temperature deviation is calculated from the plurality of sensing junctions based on electric potential at each of the sensing junctions.

Abstract: Systems and methods are provided for implementing a customizable and animatable popup card system. The popup card system includes animatable popup cards and popup card user interface (“UI”) elements, with location awareness functionality and scrolling awareness functionality. A user experience (“UX”) that is generated and displayed by the popup card system is adaptive to a multitude of scenarios and app (e.g., window) surfaces and is responsive to a variety of user inputs (including via mouse, keyboard, pen/stylus, touch, and voice). Transitioning between popup card states and/or between corresponding popup cards is smooth and seamless, and is anchored within the UI or app window, without need for users to navigate to another page or app to complete an action triggered by user input.

Abstract: The present invention relates to the technical field of clamping equipment and discloses a clamping mechanism and a clamping apparatus.

Abstract: A full-duplex transmission and reception circuit includes a transmission module, a filtering module, and an amplification module, with the transmission module having a current-mode logic architecture. A first terminal of the transmission module is connected to a first terminal of the filtering module, and a second terminal of the transmission module is connected to a second terminal of the filtering module. A third terminal of the filtering module is connected to both a first and a second terminals of the amplification module. The transmission module is configured to transmit a forward high-speed differential signal and receive a reverse low-speed common-mode signal. The filtering module is configured to filter out the forward high-speed differential signal from a mixed signal and transmit the reverse low-speed common-mode signals to the amplification module. The amplification module is configured to amplify the reverse low-speed common-mode signal.