Abstract: Surface-active, non-leaching antimicrobial film forming compositions and methods for their application to preferably medical device surfaces are provided. The compositions form durable coatings with long-lasting antimicrobial efficacy without formation of a zone of inhibition. Optionally the films can be hydrophilic. Specific long-chain molecules of certain chemical reactivity are covalently bonded into a polymeric matrix. They maintain a long-term anti-microbial efficacy without being leached out into the aqueous environment. The polymeric matrix of the compositions contain functional groups, which covalently bond to an amine, thiol, carboxyl, aldehyde or hydroxyl active group of selected long chain quaternary ammonium compounds. Upon formation of a covalent bonding with the polymeric matrix the long chain compounds become immobilized but still maintain antimicrobial efficacy.

Abstract: A radioactive source is made by forming a polymer layer substantially free of inorganic polymers on a substrate material, and exposing the polymer layer to a radioactive isotope. The source is useful for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. In particular, a radioactive source of 32P, 90Y, or 144Ce is deposited on a poly(ethylene terephtalate) (PET) substrate. The polymer substrate was first coated with pH-sensitive hydrogel and then adsorbed various amount of phosphoric acid (PA) in aqueous solutions. The substrate was immersed in 32P, 90YCl3 or 144CeCl3 solutions, and then 32P, 90Y or 144Ce was deposited on the surface as 32PPO4, 90YPO4 or 144Ce PO4. Two different polyurethanes were used to encapsulate and seal the deposited isotopes on the surface to minimize the leakage of the isotope.

Abstract: The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a polysaccharide and water.

Abstract: The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a polysaccharide and water.