Abstract: The present disclosure provides a hollow-core microstructure optical fiber preform, an optical fiber, and a method for manufacturing thereof. An objective of the present disclosure is to introduce a support sheet into a nested structure unit of the hollow-core microstructure optical fiber preform, which not only increases the number of reflection surfaces without increasing the number of nested layers of glass tubes, but also achieves a more accurate positioning by the support sheet and improves manufacturing accuracy as compared to a tangential structure of nested glass tubes, such that the following technical problems, difficulty in controlling a curvature of reflection surfaces, low manufacturing accuracy, large difference between actual loss and theoretical loss, or poor batch consistency, in related anti-resonance optical fibers, caused by increasing the number of layers of nested microstructure units in order to increase the number of reflection surfaces, are solved.

Abstract: A ultraviolet detector includes a substrate; a first epitaxial layer that is a heavily doped epitaxial layer and located on the substrate, a second epitaxial layer located on the first epitaxial layer, where the second epitaxial layer is a lightly doped epitaxial layer, or a double-layer or multi-layer structure composed of at least one lightly doped epitaxial layer and at least one heavily doped epitaxial layer; an ohmic contact layer located on the second epitaxial layer or formed in the second epitaxial layer, where the ohmic contact layer is a graphical heavily doped layer; and a first metal electrode layer located on the ohmic contact layer.

Abstract: A nucleic acid aptamer specifically recognizing soluble ST2 protein and its application, belonging to the field of variation or genetic engineering, are described. The technical problem addressed includes how to specifically detect sST2 protein. In order to address this technical problem, nucleic acid aptamers of single-stranded DNA with nucleotide sequences are shown in SEQ ID No. 1-10, respectively. SELEX technology, combined with high-throughput sequencing technology and bioinformatics analysis, reduces the rounds of screening and obtains candidate nucleic acid aptamers, and further analyzes its affinity and specificity to obtain a nucleic acid aptamer that specifically recognizes sST2 protein. The nucleic acid aptamer has the characteristics of high specificity, high stability, convenient synthesis, and easy labeling of functional groups, and the like, and may be used for the detection of sST2 protein and the preparation of biosensors, diagnosis and prognosis of cardiovascular diseases and other products.

Abstract: A pharmaceutical composition for preventing and treating diabetes comprises: cannabidiol and/or a pharmaceutically acceptable salt or ester thereof; and one or more hypoglycemic agents. Optionally, the pharmaceutical composition further comprises one or more pharmaceutically acceptable auxiliary materials. The pharmaceutical composition can effectively decrease blood sugar, and significantly mitigate an adverse reaction induced by metformin or sulfonylurea secretagogues.

Abstract: An integrated circuit includes an output driver circuit having first and second transistors coupled to an external pad of the integrated circuit and first and second multiplexer circuits. The first multiplexer circuit is configurable to cause the first transistor to be controlled by a first voltage during a data output mode of operation and to couple a first control input of the first transistor to the external pad during a hot-socket protection mode of operation. The second multiplexer circuit is configurable to cause the second transistor to be controlled by a second voltage during the data output mode of operation and to couple a second control input of the second transistor to the external pad during the hot-socket protection mode of operation.

Abstract: A process to form a composition, said process comprising at least the following steps A) and B): A) mixing together at least the following components a and b to form a first composition: a) the “anhydride-functionalized olefin-based polymer”, and b) at least one multifunctional epoxy compound comprising at least two epoxy groups, or at least one oxetane compound comprising at least one oxetane group; B) exposing the first composition to moisture to form the crosslinked olefin-based polymer. Also, related is first compositions and crosslinked compositions.

Abstract: A nucleic acid aptamer specifically recognizing soluble ST2 protein and its application, belonging to the field of variation or genetic engineering, are described. The technical problem addressed includes how to specifically detect sST2 protein. In order to address this technical problem, nucleic acid aptamers of single-stranded DNA with nucleotide sequences are shown in SEQ ID No. 1-10, respectively. SELEX technology, combined with high-throughput sequencing technology and bioinformatics analysis, reduces the rounds of screening and obtains candidate nucleic acid aptamers, and further analyzes its affinity and specificity to obtain a nucleic acid aptamer that specifically recognizes sST2 protein. The nucleic acid aptamer has the characteristics of high specificity, high stability, convenient synthesis, and easy labeling of functional groups, and the like, and may be used for the detection of sST2 protein and the preparation of biosensors, diagnosis and prognosis of cardiovascular diseases and other products.

Abstract: A cooling apparatus of a motor controller includes a water pipeline cover plate mounted on a motor controller body which includes a water pipeline inlet, an inlet of an inner water pipeline, an outlet of the inner water pipeline, and a water pipeline outlet. The water pipeline cover plate includes a water pipeline cover plate inlet, a power-module water inlet, a mounting groove, a power-module water outlet, and a water pipeline cover plate outlet. A heat-dissipation surface of the power module and a surface of the mounting groove surround a cooling accommodating cavity. The water pipeline inlet, the inlet of the inner water pipeline, the water pipeline cover plate inlet, and the water pipeline cover plate inlet communicate with the power-module water inlet, the cooling accommodating cavity, the power-module water outlet, and the water pipeline cover plate outlet.

Abstract: Described herein are methods and systems for receiving electronic messages comprising laboratory results and associating the laboratory results with appropriate laboratory result identifiers to generate mapped laboratory results. The mapped laboratory results may be used to inform clinical patient treatment and/or clinical trial design or performance.

Abstract: Disclosed are a water-soluble cannabinoid formulation and a preparation method therefor. The water-soluble cannabinoid formulation comprises a cannabinoid, an amphiphilic high-molecular polymer and cyclodextrin, wherein the content of the cannabinoid in percentages by weight is 1-40%, the content of the amphiphilic high-molecular polymer in percentages by weight is 1-90%, and the content of the cyclodextrin in percentages by weight is 1-90%; and the preparation method comprises: (1) preparing a water-soluble composite solution from a cannabinoid, an amphiphilic high-molecular polymer and cyclodextrin; (2) drying the water-soluble composite solution obtained in step (1) to obtain water-soluble cannabinoid solid particles; and (3) preparing the cannabinoid solid particles obtained in step (2) into a water-soluble cannabinoid formulation.

Abstract: The present disclosure provides a hollow-core microstructure optical fiber preform, an optical fiber, and a method for manufacturing thereof. An objective of the present disclosure is to introduce a support sheet into a nested structure unit of the hollow-core microstructure optical fiber preform, which not only increases the number of reflection surfaces without increasing the number of nested layers of glass tubes, but also achieves a more accurate positioning by the support sheet and improves manufacturing accuracy as compared to a tangential structure of nested glass tubes, such that the following technical problems, difficulty in controlling a curvature of reflection surfaces, low manufacturing accuracy, large difference between actual loss and theoretical loss, or poor batch consistency, in related anti-resonance optical fibers, caused by increasing the number of layers of nested microstructure units in order to increase the number of reflection surfaces, are solved.

Abstract: Disclosed is a preparation method for cannflavin compounds. The preparation method has the advantages of cheap and easily available raw materials, few reaction steps, short production period, simple operation, etc. The method comprises: firstly, condensing 4?-hydroxy-3?-methoxyacetophenone and diethyl carbonate (DEC) under an alkaline condition to obtain 4?-hydroxy-3?-methoxybenzoyl acetate; reacting 1,3,5-trihydroxybenzene with bromo-isoamylene under an alkaline condition to obtain 2-isopentenyl-1,3,5-trihydroxybenzene; and finally, condensing 4?-hydroxy-3?-methoxybenzoyl acetate and 2-isopentenyl-1,3,5-trihydroxybenzene at a high temperature to produce cannflavin B and/or isocannflavin B, and then subjecting same to separation and purification to obtain pure cannflavin B and pure isocannflavin B.

Abstract: The present invention belongs to the field of medicine, and relates to use of cannabidiol (CBD) in the treatment of pulmonary arterial hypertension. The CBD can be used as the only active ingredient or combined with other active ingredients to prepare a medicament for treating pulmonary arterial hypertension. Specifically, the present invention relates to use of any one selected from (1) to (3) in the preparation of a medicament for treating and/or preventing pulmonary arterial hypertension: (1) CBD, (2) a plant extract containing the CBD; and preferably, the plant extract is a cannabis extract, and (3) a pharmaceutical composition containing the CBD and one or more pharmaceutically acceptable adjuvants. In the present invention, upon experimental researches, it has found that the CBD has the function of inhibiting pulmonary arterial hypertension, and is especially suitable for treating the pulmonary arterial hypertension caused by hypoxemia.

Abstract: The present invention belongs to the field of medicine, and relates to use of cannabidiol (CBD) in the treatment of pulmonary arterial hypertension. The CBD can be used as the only active ingredient or combined with other active ingredients to prepare a medicament for treating pulmonary arterial hypertension. Specifically, the present invention relates to use of any one selected from (1) to (3) in the preparation of a medicament for treating and/or preventing pulmonary arterial hypertension: (1) CBD, (2) a plant extract containing the CBD; and preferably, the plant extract is a cannabis extract, and (3) a pharmaceutical composition containing the CBD and one or more pharmaceutically acceptable adjuvants. In the present invention, upon experimental researches, it has found that the CBD has the function of inhibiting pulmonary arterial hypertension, and is especially suitable for treating the pulmonary arterial hypertension caused by hypoxemia.

Abstract: Disclosed in the present invention is a preparation method for cannflavin compounds. The preparation method has advantages such as cheap and easily available raw materials, few reaction steps, short production period, and easy operation. The method comprises: first, condensing 4?-hydroxy-3?-methoxyacetophenone and diethyl carbonate (DEC) under an alkaline condition to obtain ethyl 4?-hydroxy-3?-methoxybenzoylacetate, next, reacting 1,3,5-trihydroxybenzene with geraniol to obtain (E)-2-(3,7-dimethyloct-2,6-dien-1-yl)benzene-1,3,5-triphenol; and finally, condensing ethyl 4?-hydroxy-3?-methoxybenzoylacetate and (E)-2-(3,7-dimethyloct-2,6-dien-1-yl)benzene-1,3,5-triphenol at high temperature to produce cannflavin A and/or cannflavin C, and then carrying out separation and purification to obtain pure cannflavin A and cannflavin C.

Abstract: A process to form a crosslinked composition, said process comprising thermally treating a composition comprising the following: a) an elastomer; b) a siloxy-modified silica; c) a hydrosilylation catalyst. A composition comprising the following: a) an elastomer; b) a siloxy-modified silica; c) a hydrosilylation catalyst.

Abstract: The present disclosure provides a method and apparatus to perform an electrochemical process by manipulating the charge on an electrode involved in the primary circuit of the electrochemical reaction. The amount of charge on the electrode can be manipulated independent of the bias voltage of the primary circuit and is accomplished by coupling the electrode with various different configurations.

Abstract: The present invention belongs to the field of medicine, and relates to use of cannabidiol (CBD) in the treatment of pulmonary arterial hypertension. The CBD can be used as the only active ingredient or combined with other active ingredients to prepare a medicament for treating pulmonary arterial hypertension. Specifically, the present invention relates to use of any one selected from (1) to (3) in the preparation of a medicament for treating and/or preventing pulmonary arterial hypertension: (1) CBD, (2) a plant extract containing the CBD; and preferably, the plant extract is a cannabis extract, and (3) a pharmaceutical composition containing the CBD and one or more pharmaceutically acceptable adjuvants. In the present invention, upon experimental researches, it has found that the CBD has the function of inhibiting pulmonary arterial hypertension, and is especially suitable for treating the pulmonary arterial hypertension caused by hypoxemia.

Abstract: The invention discloses a cannabinoid nano-micelle preparation and a preparation method thereof. The cannabinoid nano-micelle preparation includes cannabinoid and an amphiphilic polymer, wherein the content of the cannabinoid is 1-40% by weight, the content of the amphiphilic polymer is 1-99%, and the preparation method includes the following steps: (1) preparing a cannabinoid nano-micelle solution from cannabinoid and an amphiphilic polymer; (2) drying the micellar solution obtained in the step (1) to obtain cannabinoid nano-micelle powder; and (3) preparing the cannabinoid nano-micelle powder obtained in the step (2) into the cannabinoid nano-micelle preparation.