Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

Abstract: A method for modifying engine files, the method performed by at least one processor in one or more servers at a cloud based location, the method comprising receiving, by the one or more servers at the cloud based location from at least one host device, a derived data cache (DDC) generated by the at least one host device; distributing the DDC from the one or more servers at the cloud based location to one or more client locations, the one or more client locations performing at least one modification to the DDC; and receiving the modified DDC, by the one or more servers at the cloud based location from the one or more client locations.

Abstract: A battery swapping apparatus includes a movable base, a locking and unlocking mechanism, and a scissor type lifting mechanism. The locking and unlocking mechanism is configured to lock a battery to an electrical device or unlock the battery from the electrical device. The scissor type lifting mechanism is configured to drive the locking and unlocking mechanism to move up and down. The scissor type lifting mechanism includes a scissor unit, a driving member, a first transmission member, and a second transmission member. The first transmission member is mounted on the scissor unit and forms a slope fit with the second transmission member. The driving member is configured to drive the second transmission member to move, so as to drive the scissor unit to perform a scissor movement through the first transmission member.

Abstract: At least one processor identifies dependency relationships among libraries in a repository of libraries. Using the dependency relationships among libraries, at least one machine learning model can be created that predicts with a confidence value a dependency between a given library and a target library. An L layer tree-like graph can be created, using the dependency relationships among libraries and an application package. L can be configurable. Versions of the libraries to use can be determined by running the at least one machine learning model for each pair of nodes having a dependency relationship in the L layer tree-like graph, the at least one machine learning model identifying the dependency relationship with a confidence value, where pairs of nodes having largest confidence values are selected as the versions of the libraries to use in the application package.

Abstract: A sense amplifier, a memory and a method for controlling the sense amplifier are provided. The sense amplifier includes: an amplification module, arranged to read data in a memory cell; and a control module, electrically connected to the amplification module. In a first offset compensation stage of the sense amplifier, the control module is arranged to configure the amplification module to include a first inverter and a second inverter, and each of the first inverter and the second inverter is an inverter an input terminal and an output terminal connected to each other; and in a second offset compensation stage of the sense amplifier, the control module is arranged to configure the amplification module to include a current mirror structure.

Abstract: The sense amplifier includes: an amplification module configured to amplify a voltage transmitted by a bit line or a reference bit line, when the sense amplifier is at an amplification stage; a first switch module configured to control the amplification module to be disconnected from the reference bit line, when the sense amplifier performs a read operation for the bit line and is at the amplification stage. In the disclosure, the power consumption of the sense amplifier may be reduced.

Abstract: In an embodiment, described herein is a system and method for creating a suggested task set to meet a target value. A cloud server, in response to receiving a request specifying a target value, retrieves completed task sets from a database. Each completed task set includes a same set of task categories. The cloud server derives a number of ratios from the retrieved completed task sets, including a composition ratio and a conversion rate for each task category, and an addition ratio for the number of completed task sets. Based on the derived ratios and the specified target value, the cloud server constructs the suggested task set, and displays in real-time the suggested task set together with current values for the task categories. The cloud server alerts users of a discrepancy between a current value and the corresponding suggested value for a task category when the discrepancy reaches a predetermined level.

Abstract: The present disclosure relates to an open earphone. The open earphone may include a sound production device and an ear hook including a first part and a second part connected in sequence. The first part may be hooked and arranged between an auricle and a head of a user. The second part may extend to a front lateral surface of the auricle and may be connected to the sound production device. The sound production device may be worn at a position that is near an ear canal without blocking an earhole of the user. The sound production device may be at least partially inserted into an auricular concha cavity of the user. An overlap ratio of a projection area of the sound production device on a sagittal plane to a projection area of the auricular concha cavity on the sagittal plane may be not less than 44.01%.

Abstract: The disclosure provides a Sense Amplifier (SA), a memory and a method for controlling the SA, and relates to the technical field of semiconductor memories. The SA includes: an amplifier module; an offset voltage storage unit electrically connected to the amplifier module and configured to store an offset voltage of the amplifier module in an offset elimination stage of the SA; and a load compensation unit electrically connected to the amplifier module and configured to compensate a difference between loads of the amplifier module in an amplification stage of the SA. The disclosure may improve an accuracy of reading data of the SA.

Abstract: The present disclosure provides an earphone including a sound production component, an ear hook, and a microphone assembly. The microphone assembly includes a first microphone and a second microphone. The sound production component or ear hook includes a first sound hole and a second sound hole corresponding to the first microphone and second microphone, respectively. An extension line of a line connecting a projection of the first sound hole on a sagittal plane of the user and a projection of the second sound hole on the sagittal plane has an intersection point with a projection of an antihelix, a ratio of a first distance between the projection of the first sound hole on the sagittal plane and the projection of the second acoustic hole on the sagittal plane to a second distance between the projection of the second acoustic hole on the sagittal plane and the intersection point is 1.8-4.4.

Abstract: Disclosed is an open earphone, comprising a sound production component and an ear hook. The ear hook may include a first portion and a second portion connected in sequence. The first portion may be hung between the auricle of a user and the head of the user, the second portion may extend toward a front outer side of the auricle and connect the sound production component, and the sound production component may be located close to the ear canal but not block the opening of the ear canal; wherein the sound production component and the auricle may have a first projection and a second projection on a sagittal plane, respectively, a centroid of the first projection may have a first distance from a highest point of the second projection in a vertical axis direction, a ratio of the first distance to a height of the second projection in the vertical axis direction may be within a range of 0.25-0.

Abstract: A system obtains a data set representing immersive video content for display at a display time, including first data representing the content according to a first level of detail, and second data representing the content according to a second higher level of detail. During one or more first times prior to the display time, the system causes at least a portion of the first data to be stored in a buffer. During one or more second times prior to the display time, the system generates a prediction of a viewport for displaying the content to a user at the display time, identifies a portion of the second data corresponding to the prediction of the viewport, and causes the identified portion of the second data to be stored in the video buffer. At the display time, the system causes the content to be displayed to the user using the video buffer.

Abstract: A method for manufacturing a semiconductor device includes: providing a wafer-bonding stack structure having a sidewall layer and an exposed first component layer; forming a photoresist layer on the first component layer; performing an edge trimming process to at least remove the sidewall layer; and removing the photoresist layer. In this way, contaminant particles generated from the blade during the edge trimming process may fall on the photoresist layer but not fall on the first component layer, so as to protect the first component layer from being contaminated.

Abstract: Disclosed is an open earphone, comprising a sound production component and an ear hook. The ear hook may include a first portion and a second portion connected in sequence. The first portion may be hung between the auricle of a user and the head of the user, the second portion may extend toward a front outer side of the auricle and connect the sound production component, and the sound production component may be located close to the ear canal but not block the opening of the ear canal; wherein the sound production component and the auricle may have a first projection and a second projection on a sagittal plane, respectively, a centroid of the first projection may have a first distance from a highest point of the second projection in a vertical axis direction, a ratio of the first distance to a height of the second projection in the vertical axis direction may be within a range of 0.25-0.

Abstract: A clamping triaxial seepage and acoustic coupling rock tensile testing machine includes a sample and a scaffold-type tensile testing device. The scaffold-type tensile testing device has an upper chuck and a lower chuck. The upper chuck has an acoustic transmitting channel, one end of which communicating with the outside, and the other end of which having an acoustic transmitting probe. The lower chuck has an acoustic receiving channel, one end of which communicating with the outside, and the other end having acoustic receiving probe. An upper end face of the sample has with a seepage outflow hole while the upper chuck has a seepage outflow channel connected with the seepage outflow hole. A lower end face of the sample has a seepage inflow hole while the lower chuck has a seepage entry channel is connected with the seepage inflow hole.

Abstract: A human-computer interaction method and apparatus. Said method may include: receiving information of at least one modality of a user (201); identifying, on the basis of the information of the at least one modality, intention information of the user and user emotional features corresponding to the intention information (202); determining, on the basis of the intention information, reply information to the user (203); selecting, on the basis of the user emotional features, character emotional features to be fed back to the user (204); and generating, on the basis of the character emotional features and the reply information, a broadcast video of an animated character corresponding to the character emotional features (205).

Abstract: Embodiments of the present disclosure provide a positioning method and apparatus, a device, and a storage medium, the method is applied to a wearable display device, where the wearable display device includes a display host and a peripheral, the display host and/or the peripheral are used for projecting a structure light image onto an object in a real environment, and the method includes: acquiring an image obtained by the display host shooting the object, and an image obtained by the peripheral shooting the object; and determining, according to image obtained by shooting and the structure light image, a pose of the peripheral relative to the display host.

Abstract: The noise reduction earpad includes: an earpad body and an earpad cover, the earpad body is made of a porous flexible material or a foam flexible material and being in a ring shape and being connected to the connection surface, the earpad body and the connection surface jointly forming a sealed and soundproof space provided with a chamber structure having an opening; the earpad cover includes a cloth cover covering at least an exposed outer surface of the earpad body and made of a cloth material and a sealed and soundproof film attached to a side surface of cloth cover facing the earpad body and made of a soft rubber, a laying area of the sealed and soundproof film is corresponding to an outer surface of the earpad body facing away from the sealed and soundproof space.

Abstract: A damping ratio measuring device for consolidation equipment includes a bracket, a consolidation pressure device and a sleeve. The consolidation pressure device is set at the top of the bracket, and the output direction of the consolidation pressure device is directly below. The bottom of the consolidation pressure device is connected with a pressurized piston. A displacement sensor is set on the pressurized piston. The sleeve is set directly below the consolidation pressure device, the pressurized piston extends from the top of the sleeve, the diameter of the pressurized piston is the same as the inner diameter of the sleeve, the bottom of the sleeve is sealed with a support plate, and there are two bending element sensors at the top of the support plate and the bottom of the pressurized piston.

Abstract: Implementations relate to maintaining metadata, of a client device, stored on a remote computing device, to reduce overall network utilization and/or latency in responding to automated assistant requests received at the client device. The metadata of a client device is identified and provided to a remote computing device with a request that requires additional processing by the remote computing device. Current metadata is compared to previously provided metadata that was provided to the remote computing device with a previous request and one or more operations are generated based on the difference between the current metadata and the previous metadata. The remote computing device executes the one or more operations on a remote version of the metadata to generate a new remote version of the metadata of the client device. The remote computing device further processes the request with the new remote version of the metadata.