Patents by Inventor Xin ZHEN

Xin ZHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolo[2?,3?:3,4]pyrido[2,1-b]quinazoline compound and use thereof
    Patent number: 12590093
    Abstract: The disclosure relates to an indolo[2?,3?:3,4]pyrido[2,1-b]quinazoline compound represented by general formula (I) and use thereof in the manufacture of (1) a medicament for treating a cardiovascular and cerebrovascular disease, (2) a formulation for increasing expression of AMPK, ABCA1 and SR-BI, (3) a formulation for activating nuclear receptors (NRs), and inhibiting activity of NLRP3, IL-1?, NF-?B and MAPKs, (4) a formulation for promoting cellular cholesterol efflux; or (5) a medicament for anti-inflammation.
    Type: Grant
    Filed: September 27, 2020
    Date of Patent: March 31, 2026
    Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Shuyi Si, Yanni Xu, Xiao Wang, Jinque Luo, Yongzhen Li, Chao Liu, Xinhai Jiang, Yining Li, Xiaowan Han, Yan Li, Minghua Chen, Jing Zhang, Xin Zhen
  • A GROUP OF PEPTIDE DERIVATIVE OMICSYNINS WITH ANTIVIRAL ACTIVITY AND USES THEREOF
    Publication number: 20230365632
    Abstract: This disclosure related to a group of peptide derivative Omicsynins with antiviral activity against influenza virus and coronavirus. It also related uses of these derivatives, the chemical formula of the peptide derivative Omicsynins is shown in formula (1): R1—R4 are shown in the following table. NO. substituent1 substituent2 substituent3 R1 Basic amino-acid side chains including lysine, histidine, citrulline residues, and etc. R2 —CH(CH3)2, —CH(CH3)CH2CH3 —CH2CH(CH3)2 Neutral amino-acid side chain including tryptophan, serine, threonine, cysteine residues and etc. R3 R3 including tyrosine, lysine, histidine, citrulline residues, and etc. R4 —CH2OH —CHO R4 including —CH2NH2, —CH?NH,— CH?NOH, —COOH, —COOR5 (R5 represents alkyl groups containing 1-3 carbons), -CONH2 and etc.
    Type: Application
    Filed: February 10, 2021
    Publication date: November 16, 2023
    Inventors: Shuyi SI, Bin HONG, Yuhuan LI, Hongmin SUN, Jiandong JIANG, Xingxing LI, Minghua CHEN, Rongmei GAO, Yongsheng CHE, Xin ZHEN, Liyan YU, Hongyu LIU, Ming ZHONG, YeXiang WU, Yuanyuan SHI
  • GROUP OF TETRAHYDROINDOLOQUINAZOLINE COMPOUNDS AND USE THEREOF
    Publication number: 20220402918
    Abstract: The disclosure relates to an indolo[2?,3?:3,4]pyrido[2,1-b]quinazoline compound represented by general formula (I) and use thereof in the manufacture of (1) a medicament for treating a cardiovascular and cerebrovascular disease, (2) a formulation for increasing expression of AMPK, ABCA1 and SR-BI, (3) a formulation for activating nuclear receptors (NRs), and inhibiting activity of NLRP3, IL-1?, NF-?B and MAPKs, (4) a formulation for promoting cellular cholesterol efflux; or (5) a medicament for anti-inflammation.
    Type: Application
    Filed: September 27, 2020
    Publication date: December 22, 2022
    Inventors: Shuyi SI, Yanni XU, Xiao WANG, Jinque LUO, Yongzhen LI, Chao LIU, Xinhai JIANG, Yining LI, Xiaowan HAN, Yan LI, Minghua CHEN, Jing ZHANG, Xin ZHEN