Patents by Inventor Xinchen Wang

Xinchen Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELLULAR STAINING PROBES FOR ANALYTE DETECTION
    Publication number: 20240401119
    Abstract: The present disclosure relates to, in part, cleavable probes for detection of multiple analytes in a single sample and methods of use thereof. Specifically, probes comprising a binding agent linked to a detectable label by a cleavable linker (for example, a linker comprising a disulfide bond) can be used to detect analytes, then cleaved to remove the label, thus allowing further probing and detection of additional analytes.
    Type: Application
    Filed: August 8, 2024
    Publication date: December 5, 2024
    Inventors: Xinchen Wang, David Vincent Phizicky
  • METHODS FOR HIGH-RESOLUTION GENOME-WIDE FUNCTIONAL DISSECTION OF TRANSCRIPTIONAL REGULATORY REGIONS
    Publication number: 20240384258
    Abstract: Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.
    Type: Application
    Filed: May 17, 2024
    Publication date: November 21, 2024
    Inventors: Melina Claussnitzer, Liang He, Manolis Kellis, Xinchen Wang
  • Methods for high-resolution genome-wide functional dissection of transcriptional regulatory regions
    Patent number: 11987790
    Abstract: Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: May 21, 2024
    Assignees: Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center
    Inventors: Melina Claussnitzer, Liang He, Manolis Kellis, Xinchen Wang
  • METHODS FOR HIGH-RESOLUTION GENOME-WIDE FUNCTIONAL DISSECTION OF TRANSCRIPTIONAL REGULATORY REGIONS
    Publication number: 20200407710
    Abstract: Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.
    Type: Application
    Filed: October 17, 2018
    Publication date: December 31, 2020
    Inventors: Melina Claussnitzer, Liang He, Manolis Kellis, Xinchen Wang