Patents by Inventor Xinde Xu

Xinde Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10844319
    Abstract: The present invention provides a fatty glyceride preparation method, comprising converting fatty acid short-chain alcohol ester into fatty glyceride basic mixture by sequentially carrying out a normal-pressure reaction and a vacuum reaction in the nitrogen condition in the temperature of 80° C. to 150° C.; and meanwhile adding a basic catalyst and glycerin or adding a basic catalyst and a glycerin derivative into the fatty acid short-chain alcohol ester, so as to implement a conversion from the fatty acid short-chain alcohol ester to the fatty glyceride. Conditions of the preparation method are relatively moderate, and the structure of the fatty acid is not damaged in the reactions; the yield of the glyceride is high, compositions of the glyceride are stable and controllable, glyceride products having a high content of triacylglycerol can be obtained; the process is simple, costs are low, and the fatty glyceride is applicable to industrial production.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: November 24, 2020
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
    Inventors: Yongjian Peng, Xinde Xu, Shengnan Wang, Yuli Yu, Bin Shao
  • Patent number: 10821412
    Abstract: The present invention provides a method for drying high-stability microcapsule particles containing multiple double bonds fat soluble nutrients comprises: a) preparing a microcapsule emulsion containing multiple double bonds fat soluble nutrients, performing spray granulation on the microcapsule emulsion in a spray system (1), and meanwhile blasting air into the spray system (1), the blasted air wrapping adsorption materials, and the microcapsule emulsion being immediately solidified and sized after coming into contact with the air, so as to obtain liquid droplets having surfaces to which adsorption materials are adsorbed; b) performing fluidized drying on the liquid droplets having surfaces to which the adsorption materials are adsorbed in the step a) in a multi-stage fluidized bed system (5); c) collecting non-adsorbed adsorption materials by means of an adsorption material dust removal, recovery and circulation system; and d) collecting microcapsule particle products.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: November 3, 2020
    Assignee: Zhejiang Madicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Lihua Zhang
  • Patent number: 10787422
    Abstract: The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: September 29, 2020
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Jianhua Shen, Yiping Wang, Xinde Chen, Wenwei Xu, Kai Wang
  • Patent number: 10568843
    Abstract: The present invention provides a method of preparing highly stable microcapsule powders or microparticles containing a fat-soluble nutrient having multiple double bonds.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: February 25, 2020
    Assignee: Zhejiang Medicine Co., Ltd
    Inventors: Xinde Xu, Di Zhou, Lihua Zhang, Bin Shao
  • Publication number: 20190256448
    Abstract: The present invention provides a fatty glyceride preparation method, comprising converting fatty acid short-chain alcohol ester into fatty glyceride basic mixture by sequentially carrying out a normal-pressure reaction and a vacuum reaction in the nitrogen condition in the temperature of 80° C. to 150° C.; and meanwhile adding a basic catalyst and glycerin or adding a basic catalyst and a glycerin derivative into the fatty acid short-chain alcohol ester, so as to implement a conversion from the fatty acid short-chain alcohol ester to the fatty glyceride. Conditions of the preparation method are relatively moderate, and the structure of the fatty acid is not damaged in the reactions; the yield of the glyceride is high, compositions of the glyceride are stable and controllable, glyceride products having a high content of triacylglycerol can be obtained; the process is simple, costs are low, and the fatty glyceride is applicable to industrial production.
    Type: Application
    Filed: August 1, 2017
    Publication date: August 22, 2019
    Inventors: Yongjian PENG, Xinde XU, Shengnan WANG, Yuli YU, Bin SHAO
  • Publication number: 20190248751
    Abstract: The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.
    Type: Application
    Filed: March 12, 2019
    Publication date: August 15, 2019
    Inventors: Jianhua Shen, Yiping Wang, Xinde Chen, Wenwei Xu, Kai Wang
  • Publication number: 20190193042
    Abstract: The present invention provides a method for drying high-stability microcapsule particles containing multiple double bonds fat soluble nutrients comprises: a) preparing a microcapsule emulsion containing multiple double bonds fat soluble nutrients, performing spray granulation on the microcapsule emulsion in a spray system (1), and meanwhile blasting air into the spray system (1), the blasted air wrapping adsorption materials, and the microcapsule emulsion being immediately solidified and sized after coming into contact with the air, so as to obtain liquid droplets having surfaces to which adsorption materials are adsorbed; b) performing fluidized drying on the liquid droplets having surfaces to which the adsorption materials are adsorbed in the step a) in a multi-stage fluidized bed system (5); c) collecting non-adsorbed adsorption materials by means of an adsorption material dust removal, recovery and circulation system; and d) collecting microcapsule particle products.
    Type: Application
    Filed: October 12, 2015
    Publication date: June 27, 2019
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Lihua Zhang
  • Publication number: 20180303761
    Abstract: The present invention provides a method of preparing highly stable microcapsule powders or microparticles containing a fat-soluble nutrient having multiple double bonds.
    Type: Application
    Filed: October 12, 2015
    Publication date: October 25, 2018
    Inventors: Xinde Xu, Di Zhou, Lihua Zhang, Bin Shao
  • Patent number: 10035750
    Abstract: The present invention relates to a preparation method for a polyunsaturated fatty acid-calcium, primarily comprising directly reacting a polyunsaturated fatty acid material with a water-soluble calcium compound to obtain a polyunsaturated fatty acid-calcium salt. The present invention has a simple technical process, short reaction time, and high reaction yield. The produced polyunsaturated fatty acid-calcium product is of high quality, and relatively less byproducts and waste water are produced. The process is overall environmentally friendly and has small safety risks, and is suitable for scaled production.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: July 31, 2018
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
    Inventors: Xuebing Xiang, Xinde Xu, Bin Shao, Yufang Meng, Chong Li
  • Patent number: 10028914
    Abstract: The present invention describes a reduction type coenzyme Q10 powder, a composition thereof, and a preparation method thereof. The reduction type coenzyme Q10 powder is obtained by reacting an oxidation type coenzyme Q10 with the presence of a reducing agent, removing an organic solvent and other purities from a reaction solution after the reaction is finished to obtain an oil-soluble reduction type coenzyme Q10 liquid, and then directly performing prill formation with cold wind on an obtained reduction type coenzyme Q10 greasy substance. The obtained reduction type coenzyme Q10 powder has a lower crystallinity, and in a Cu-K[alpha] X-ray diffraction spectrum, has a strong peak at a diffraction angle 2[theta] being 18.9 DEG, and has a very strong absorption peak at a diffraction angle 2[theta] being 22.8 DEG.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 24, 2018
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICA FACTORY
    Inventors: Xinde Xu, Gang Chen, Xuejun Lao, Lihua Zhang, Xiaoxia Sun, Xiaoyue Jiang
  • Patent number: 10030212
    Abstract: The present invention relates to a method for preparing glyceride type polyunsaturated fatty acids. The method comprises: firstly mixing a basic catalyst with glycerol or a glyceride uniformly; then adding the mixture to a polyunsaturated fatty acid material slowly, and carrying out an esterification reaction under certain conditions to obtain glyceride type polyunsaturated fatty acids, wherein the basic catalyst is a lower aliphatic alcohol sodium/potassium or a solution thereof. The procedure of the process is simple, has mild reaction conditions, short reaction time, high yield and good quality of the obtained product.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: July 24, 2018
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
    Inventors: Xuebing Xiang, Xinde Xu, Bin Shao, Chong Li
  • Patent number: 10011550
    Abstract: A method for preparing high-content conjugated linoleic acid (CLA) through purification of vegetable oil includes alcoholysis, purification and isomerization of vegetable oil. Alcoholysis is for preparing corresponding methyl ester or ethyl ester with glyceride; purification of methyl ester or ethyl ester is for obtaining methyl linoleate or ethyl linoleate of content over 85% through silver-based silica gel column chromatography; high-content CLA is obtained after alkali-catalyzed conjugation of methyl linoleate or ethyl linoleate, and CLA products are prepared as needed. This invention changes the status quo of preparing high-content CLA with safflower oil alone, expands sources of CLA, and develops an efficient technology for separation and purification of linoleic acid. The CLA obtained is of high purity and meets applications in pharmaceutical, health care products and other industries.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: July 3, 2018
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
    Inventors: Yongjian Peng, Xinde Xu, Bin Shao, Lihua Zhang
  • Patent number: 9889173
    Abstract: The present invention provides a composition for improving macular pigment optical density and preventing or treating age-related macular optical degeneration. The composition comprises lutein, zeaxanthin and tea extracts, wherein the weight ratio of zeaxanthin to lutein is more than or equal to 1. The composition may prevent formation of choroidal neovascularization to achieve effects on comprehensively preventing or treating age-related macular optical degeneration (AMD).
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: February 13, 2018
    Assignee: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Lihua Zhang, Xiaoxia Sun
  • Publication number: 20170275228
    Abstract: A method for preparing high-content conjugated linoleic acid (CLA) through Purification of vegetable oil includes alcoholysis, purification and isomerization of vegetable oil. Alcoholysis is for preparing corresponding methyl ester or ethyl ester with glyceride; purification of methyl ester or ethyl ester is for obtaining methyl linoleate or ethyl linoleate of content over 85% through silver-based silica gel column chromatography; high-content CLA is obtained after alkali-catalyzed conjugation of methyl linoleate or ethyl linoleate, and CLA products are prepared as needed. This invention changes the status quo of preparing high-content CLA with safflower oil alone, expands sources of CLA, and develops an efficient technology for separation and purification of linoleic acid. The CLA obtained is of high purity and meets applications in pharmaceutical, health care products and other industries.
    Type: Application
    Filed: September 17, 2015
    Publication date: September 28, 2017
    Applicant: ZHEJIANG MEDICINE CO., LTD., XINCHANG PHARMACEUTICAL FACTORY
    Inventors: YONGJIAN PENG, XINDE XU, BIN SHAO, LIHUA ZHANG
  • Publication number: 20170251705
    Abstract: The present invention relates to a fixed bed decolorization process for an polyunsaturated fatty acid, comprising a polyunsaturated fatty acid or a polyunsaturated fatty acid solution is either passed directly through a filler of the fixed bed or recycled in a filler of the fixed bed, a colorless or light-colored polyunsaturated fatty acid product is ultimately produced, at the same time, other than the color, other qualities of the polyunsaturated fatty acid remain unaffected. The decolorization process allows continuous operation or intermittent operation. The filler of the fixed bed comprises one or a mixture of activated carbon, diatomite, carclazyte, silicone and an ion-exchange resin. An upper or a middle or a bottom or a combination thereof is employed to feed a polyunsaturated fatty acid feedstock or a polyunsaturated fatty acid solution. The filler in the fixed bed can be used repeatedly.
    Type: Application
    Filed: September 9, 2015
    Publication date: September 7, 2017
    Inventors: Xuebing XIANG, Xinde XU, Bin SHAO, Chong LI
  • Publication number: 20170240507
    Abstract: The present invention discloses a method for recycling urea in the process of separating and purifying unsaturated substances through a urea adduction method. The method comprises the following steps: liposoluble substances containing target unsaturated components are used as raw materials, and subjected to urea adduction, crystallization and filtration to produce a filtrate, from which the specific unsaturated components are obtained; the urea adduct is dissolved in a polar solvent, and after the adducted adducts are layered and released, adding a certain solvent to the urea solution to adjust the polarity, then cooling for crystallization, and recycling the urea.
    Type: Application
    Filed: October 12, 2015
    Publication date: August 24, 2017
    Applicant: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutica l Factory
    Inventors: Yongjian Peng, Xinde Xu, Jinping Ma, Yanwen Zhang, Bin Shao
  • Publication number: 20170226446
    Abstract: The present invention relates to a method for preparing glyceride type polyunsaturated fatty acids. The method comprises: firstly mixing a basic catalyst with glycerol or a glyceride uniformly; then adding the mixture to a polyunsaturated fatty acid material slowly, and carrying out an esterification reaction under certain conditions to obtain glyceride type polyunsaturated fatty acids, wherein the basic catalyst is a lower aliphatic alcohol sodium/potassium or a solution thereof. The procedure of the process is simple, has mild reaction conditions, short reaction time, high yield and good quality of the obtained product.
    Type: Application
    Filed: October 12, 2015
    Publication date: August 10, 2017
    Applicant: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xuebing XIANG, Xinde XU, Bin SHAO, Chong LI
  • Publication number: 20170226445
    Abstract: The present invention relates to a preparation method for a polyunsaturated fatty acid-calcium, primarily comprising directly reacting a polyunsaturated fatty acid material with a water-soluble calcium compound to obtain a polyunsaturated fatty acid-calcium salt. The present invention has a simple technical process, short reaction time, and high reaction yield. The produced polyunsaturated fatty acid-calcium product is of high quality, and relatively less byproducts and waste water are produced. The process is overall environmentally friendly and has small safety risks, and is suitable for scaled production.
    Type: Application
    Filed: October 12, 2015
    Publication date: August 10, 2017
    Inventors: Xuebing XIANG, Xinde XU, Bin SHAO, Yufang MENG, Chong LI
  • Patent number: 9622497
    Abstract: A carotenoid oil suspension and preparation method thereof are provided. The method includes the following steps: a) mixing carotenoid with organic solvent, heating the mixture to dissolve the carotenoid sufficiently to obtain carotenoid solution; b) introducing the carotenoid solution obtained in step a) into a vegetable oil solution stirred in high speed by spraying, meanwhile recovering the organic solvent generated during spraying under vacuum condition, then, simultaneously completing recycling and spraying, thereafter, obtaining carotenoid oil suspension; wherein, the carotenoid oil suspension comprises a carotenoid crystal with an average particle size of less than 5 ?m. The method is applicable in industrial scale with continuous operation and increased efficiency without additional carotenoid crystal grinding processes, and decreases the degradation of carotenoid during the preparation process of carotenoid oil suspension.
    Type: Grant
    Filed: January 30, 2011
    Date of Patent: April 18, 2017
    Assignee: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Bin Shao, Xuejun Lao
  • Publication number: 20160331699
    Abstract: The present invention provides a high-content carotenoid compound from adonis amurensis. The content of the total carotenoid of the carotenoid compound is greater than 95%. The content of all-trans (3S, 3?S)-carotenoid is greater than 80%. The carotenoid crystals have a high purity, and can be used in multiple forms in the fields of a dietary supplement of a human being, a food additive, a feed additive and a cosmetic product. In addition, the present invention also provides a method for manufacturing the compound.
    Type: Application
    Filed: September 23, 2014
    Publication date: November 17, 2016
    Inventors: Xinde Xu, Bin Shao, Yongjian Peng, Shengnan Wang