Patents by Inventor Xing Dai

Xing Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridazinone compounds
    Patent number: 12715858
    Abstract: Provided herein are compounds, in particular, Compound 1, and compositions useful for treating or preventing diseases or disorders that are modulated by thyroid hormone receptor agonists, such as non-alcoholic steatohepatitis (NASH) or non-alcoholic fatty liver disease (NAFLD).
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: August 25, 2026
    Assignee: INVENTISBIO CO., LTD.
    Inventors: Xing Dai, Yanqin Liu, Yueheng Jiang
  • Solid dispersions
    Patent number: 12697337
    Abstract: Provided herein are solid dispersions and pharmaceutical compositions of Compound 1. Also provided are methods of treating a disease or disorder such as a cancer or infectious disease that comprises administering to a subject in need thereof the solid dispersions or compositions described herein.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: August 4, 2026
    Assignee: InventisBio Co., Ltd.
    Inventors: Xing Dai, Xiaomei Wang, Yanqin Liu, Yueheng Jiang, Yaolin Wang
  • HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20260184692
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical compositions comprising a compound having a Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof, methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KIF18A in a cell, and/or in treating various cancers associated with KIF18A protein.
    Type: Application
    Filed: November 24, 2023
    Publication date: July 2, 2026
    Inventors: Xing DAI, Younong YU, Hong YANG, Yong LUO, Jifang WENG, Rongfeng LIU, Yaolin WANG
  • Heteroaryl compounds, solid forms, preparation methods and uses thereof
    Patent number: 12655123
    Abstract: Provided herein are compounds, crystalline free forms, crystalline salt forms, and pharmaceutical compositions of Compound 1. Also provided are methods of preparing and methods of using the same, e.g., for inhibiting a kinase and/or for treating various diseases or disorders, such as autoimmune diseases.
    Type: Grant
    Filed: June 17, 2025
    Date of Patent: June 16, 2026
    Assignees: InventisBio Co., Ltd.
    Inventors: Wei Li, Yanqin Liu, Xing Dai
  • HETEROARYL COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20260152483
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula I, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting TYK2, and/or function of IL-12, IL-23 and/or INF-alpha, and/or in treating various associated diseases or disorders.
    Type: Application
    Filed: November 7, 2025
    Publication date: June 4, 2026
    Inventors: Xing DAI, Xianhai HUANG, Hong YANG, Zixing HAN, Haotao NIU, Jifang WENG, Zhe SHI, Yanqin LIU, Yueheng JIANG, Yaolin WANG
  • Video processing
    Patent number: 12610111
    Abstract: A method is provided that includes: obtaining playback behavior data of a video to be processed; determining, based on the playback behavior data, a target video segment in which a content segmentation point of the video is located; extracting an audio feature of the target video segment; and determining the content segmentation point from the target video segment based on the audio feature.
    Type: Grant
    Filed: April 9, 2024
    Date of Patent: April 21, 2026
    Assignee: BEIJING DUYOU INFORMATION TECHNOLOGY CO., LTD.
    Inventors: Zonggui Sui, Xing Dai, Lei Yuan, Wengui Cai
  • Salts of indoleamine 2,3-dioxygenase inhibitors
    Patent number: 12509448
    Abstract: Provided herein are compounds, salts, crystalline forms, and pharmaceutical compositions that are related to IDO inhibitors, in particular, Compound 1,1-(5-((4-chlorophenyl)amino)-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)pyridin-3-yl)cyclobutane-1-carboxylic acid. Also provided are methods of treating a disease or disorder such as a cancer or infectious disease that comprises administering to a subject in need thereof one or more of the compounds or compositions of the present disclosure.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: December 30, 2025
    Assignee: INVENTISBIO CO., LTD.
    Inventors: Xing Dai, Yueheng Jiang, Yanqin Liu
  • Heteroaryl compounds, preparation methods and uses thereof
    Patent number: 12492184
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting TYK2, and/or function of IL-12, IL-23 and/or INF-alpha, and/or in treating various associated diseases or disorders.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: December 9, 2025
    Assignees: InventisBio Co., Ltd., InventisBio LLC
    Inventor: Xing Dai
  • THYROID HORMONE RECEPTOR AGONISTS
    Publication number: 20250340542
    Abstract: Provided herein are novel thyroid hormone receptor (TR) agonists, e.g., having Formula I, II, or III. Also provided are methods of preparing the novel TR agonists and method of using the novel TR agonists for treating diseases or disorder modulated by TR agonists, such as NAFLD, NASH, diabetes, hyperlipidemia and/or hypercholesterolemia.
    Type: Application
    Filed: July 16, 2025
    Publication date: November 6, 2025
    Inventors: Xing DAI, Yaolin WANG, Yueheng JIANG, Yanqin LIU, Zixing HAN, Zhenwu WANG, Liangshan TAO, Zhe SHI
  • HETEROARYL COMPOUNDS, SOLID FORMS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20250313545
    Abstract: Provided herein are compounds, crystalline free forms, crystalline salt forms, and pharmaceutical compositions of Compound 1. Also provided are methods of preparing and methods of using the same, e.g., for inhibiting a kinase and/or for treating various diseases or disorders, such as autoimmune diseases.
    Type: Application
    Filed: June 17, 2025
    Publication date: October 9, 2025
    Inventors: Wei LI, Yanqin LIU, Dongmei QIANG, Xiaojun WANG, Xing DAI
  • C-terminal SRC kinase inhibitors
    Patent number: 12427146
    Abstract: Provided herein are novel C-terminal Srk Kinase (CSK) inhibitors, e.g., having Formula G, I, II, or III. Also provided are methods of preparing the novel CSK inhibitors and method of using the novel CSK inhibitors for treating diseases or disorder such as cancer or for promoting immune response in a subject in need thereof.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: September 30, 2025
    Assignee: INVENTISBIO CO., LTD.
    Inventors: Xing Dai, Yaolin Wang, Yueheng Jiang, Yanqin Liu, Zhe Shi, Zhenwu Wang, Zixing Han, Liangshan Tao
  • COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20250263394
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula A, B, C, D, E, or F, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting PI3K in a cell, and/or in treating various diseases such as cancer.
    Type: Application
    Filed: April 24, 2023
    Publication date: August 21, 2025
    Inventors: Xing DAI, Yanxin YU, Hong YANG, Younong YU, Xianhai HUANG, Jifang WENG, Yaolin WANG
  • Thyroid hormone receptor agonists
    Patent number: 12391677
    Abstract: Provided herein are novel thyroid hormone receptor (TR) agonists e.g., having Formula I, II, or III. Also provided are methods of preparing the novel TR agonists and method of using the novel TR agonists for treating diseases or disorder modulated by TR agonists, such as NAFLD, NASH, diabetes, hyperlipidemia and/or hypercholesterolemia.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: August 19, 2025
    Assignee: INVENTISBIO CO., LTD.
    Inventors: Xing Dai, Yaolin Wang, Yueheng Jiang, Yanqin Liu, Zixing Han, Zhenwu Wang, Liangshan Tao, Zhe Shi
  • KINASE INHIBITORS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20250223301
    Abstract: Provided herein are novel compounds, for example, compounds having a structure according to Formula III-1 to III-12, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting DGKs in a cell, and/or in treating various diseases such as cancer or viral infections.
    Type: Application
    Filed: March 31, 2023
    Publication date: July 10, 2025
    Inventors: Younong YU, Xianhai HUANG, Yong LUO, Haotao NIU, Hong YANG, Jifang WENG, Yaolin WANG, Xing DAI
  • KINASE INHIBITORS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20250215014
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula I, Formula II-1 to II-7, Formula III-1 to III-9, IV, or V, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting DGKa and/or DGKz in a cell, and/or in treating various diseases such as cancer or viral infections.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 3, 2025
    Inventors: Younong YU, Xianhai HUANG, Yong LUO, Haotao NIU, Hong YANG, Jifang WENG, Yaolin WANG, Xing DAI
  • CDK2 INHIBITOR AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20250195475
    Abstract: The present invention discloses a compound represented by formula 1a or formula 1b, an optical isomer, prodrug or pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and their use in preparation of a CDK2 inhibitor
    Type: Application
    Filed: January 27, 2022
    Publication date: June 19, 2025
    Inventors: Yanxin YU, Younong YU, Xianhai HUANG, Hong YANG, Rongfeng LIU, Jifang WENG, Yaolin WANG, Xing DAI
  • Heterocyclic compounds, preparation methods and uses thereof
    Patent number: 12246020
    Abstract: Provided herein are compounds, crystalline forms, and pharmaceutical compositions of Compound 1 and/or Compound 2. Also provided are methods of treating a disease or disorder such as a cancer or infectious disease that comprises administering to a subject in need thereof one or more of the compounds or compositions of the present disclosure.
    Type: Grant
    Filed: November 22, 2023
    Date of Patent: March 11, 2025
    Assignee: InventisBio Co., Ltd.
    Inventors: Xing Dai, Yueheng Jiang, Yanqin Liu
  • EGFR inhibitors
    Patent number: 12227491
    Abstract: Provided herein are compounds, salts, solid forms, and pharmaceutical compositions that are related to EGFR inhibitors, such as N-(2-((2-(dimethylanino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide, as well as methods of preparing the same. Also provided herein are methods of using the compounds, salts, solid forms, and pharmaceutical compositions for the treatment of diseases or disorders, such as cancer.
    Type: Grant
    Filed: March 21, 2023
    Date of Patent: February 18, 2025
    Assignee: INVENTISBIO CO., LTD.
    Inventors: Xing Dai, Yueheng Jiang
  • Selective estrogen receptor degraders and uses thereof
    Patent number: 12187736
    Abstract: The present disclosure provides compounds of Formula (I) and Formula (II). The compounds described herein may be useful in treating proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
    Type: Grant
    Filed: July 11, 2023
    Date of Patent: January 7, 2025
    Assignee: InventisBio LLC
    Inventors: Xing Dai, Yaolin Wang
  • Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
    Patent number: 12173010
    Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.
    Type: Grant
    Filed: May 12, 2023
    Date of Patent: December 24, 2024
    Assignee: INVENTISBIO CO., LTD.
    Inventors: Xing Dai, Yaolin Wang, Yueheng Jiang, Yanqin Liu, Haotao Niu, Zhenwu Wang, Zixing Han, Liangshan Tao, Jifang Weng, Zhe Shi