Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), or a pharmaceutically acceptable N salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting TYK2, and/or function of IL-12, IL-23 and/or INF-alpha, and/or in treating various associated diseases or disorders.

Abstract: An array substrate and a display apparatus are provided The array substrate includes: at least one adjusting portion on the base substrate and having a first cross section in a plane perpendicular to the base substrate; first cross section includes top and bottom sides, first and second lateral sides; the bottom side is closer to the base substrate than the top side, an orthographic projection of the top side on the base substrate is within an orthographic projection of the bottom side on the base substrate; the first and/or second lateral sides is/are stepped; a buffer layer on a side of the adjusting portion away from the base substrate; light-emitting devices on a side of the buffer layer away from the base substrate and each including a first electrode, a light-emitting layer and a second electrode sequentially arranged along a direction away from the base substrate.

Abstract: Methods and systems for techniques for determining uplink common frequency resources are disclosed. In an implementation, a method of wireless communication includes determining, by a first device, one or multiple common resources for a transmission based on one or multiple sets of slots, and performing the transmission using the one or multiple common resources.

Abstract: Provided are a time domain resource allocation method and apparatus. The method includes the following operations. A terminal acquires at least one of first information including search space configuration information, control resource set (CORESET) configuration information, and a bandwidth part type. A PDSCH time domain resource allocation table is subsequently determined according to the first information and a multiplexing pattern between a synchronization signal/physical broadcast channel block (SSB) and a CORESET.

Abstract: The present disclosure relates to determining measurement resource for measuring interference, including determining, by a first network node; measurement resource configured to receive Reference Signal (RS), receiving, by the first network node from the second network node, the RS in the measurement resource, and determining interference of operations of the second network node on operations of the first network node based on the received RS.

Abstract: A display panel includes: plurality of pixel circuits arranged on base substrate, at least one pixel circuit includes a drive transistor and a first switch transistor an active layer arranged on base substrate and including a first active portion and a second active portion, the first active portion configured to form a channel portion of the drive transistor, the second active portion is configured to form a second electrode connection portion of the first switch transistor; and a first conductive layer arranged on a side of the active layer away from the base substrate, the first conductive layer includes a first conductive portion, a portion of the first conductive portion used to form a gate electrode of the drive transistor another portion is electrically connected to the second active portion, and a channel length of the channel portion of the drive transistor is greater than a channel width.

Abstract: An organic light-emitting diode (OLED) display substrate, a manufacturing method thereof and a display panel are provided. The OLED display substrate has pixel regions and includes a base substrate and a pixel defining layer disposed on the base substrate; in regions of the pixel defining layer corresponding to the pixel regions, accommodation parts penetrating the pixel defining layer are disposed, and the pixel defining layer is further provided with guide parts disposed corresponding to the accommodation parts, the guide parts are located on a periphery of the corresponding accommodation parts and formed by recessed areas which are formed on a side of the pixel defining layer away from the base substrate, the recessed areas do not penetrate the pixel defining layer, and an orthographic projection of the guide part on the base substrate is directly coupled to an orthographic projection of the corresponding accommodation part on the base substrate.

Abstract: An application of ellagic acid and a metabolic derivative urolithin compound thereof in preparation of an immunomodulatory medicine is provided. Classical animal models of autoimmunity and immunoregulation, such as experimental autoimmune encephalomyelitis, neuromyelitis optica mouse model, ulcerative colitis, and skin transplantation, are used as examples to conduct experiments from various aspects and perspectives, such as neurological function scores, histopathological changes of lesions, inflammatory factor expression, and pro-inflammatory cell numbers.

Abstract: An online system generates a set of content item variations for a reference content item that include different styles of text for the content item. The different styles of text are generated by applying machine-learned style transfer models, for example, neural network based models to reference text of the reference content item. The text variations retain the textual content of the reference text but are synthesized with different styles. The online system can provide the content item variations to users on an online experimental platform to collect user interaction information that may indicate how users respond to different styles of text. The online system or the content providers can effectively target users with content items that include the style of text the users respond to based on the collected information.

Abstract: Disclosed is a preparation method of a foamed aluminum special-shaped part. The preparation method comprises the following steps: S1, pressing wax molds; S2, making a shell; S3, carrying out smelting; S4, carrying out casting; and S5, vibrating the shell. Finally, the foamed aluminum special-shaped part is obtained for a preparation process of a foamed aluminum compound casting.

Abstract: The application discloses a preparation method for an aluminum alloy cavity casting filled with special-shaped foamed aluminum. The preparation method includes: preparing special-shaped foamed aluminum in a first mold by adopting a powder metallurgy foaming method; fixing the special-shaped foamed aluminum coated with the soldering flux in a second mold after the special-shaped foamed aluminum is coated with soldering flux; and casting by using molten aluminum alloy. According to the preparation method for the aluminum alloy cavity casting filled with the special-shaped foamed aluminum, the overall strength of the casting can be improved while the wall thickness of the casting is reduced to meet the requirement that the overall quality of the casting is not increased.

Abstract: A fatigue measurement method includes obtaining a face video of a target object, processing the facial video to obtain a plurality of quasi-heart rates and a plurality of quasi-vibration frequencies, selecting a target heart rate from the plurality of quasi-heart rates and a target vibration frequency from the plurality of quasi-vibration frequencies, detecting the target heart rate and the target vibration frequency, and determining, according to the detection result, that the target object is in a fatigue state. The quasi-heart is obtained through one or more of a region of interest (ROI) between eyebrows and an ROI of chin, and the quasi-vibration frequency obtained through one or more of an ROI of eyes and an ROI of mouth.

Abstract: An online system generates a set of content item variations for a reference content item that include different styles of text for the content item. The different styles of text are generated by applying machine-learned style transfer models, for example, neural network based models to reference text of the reference content item. The text variations retain the textual content of the reference text but are synthesized with different styles. The online system can provide the content item variations to users on an online experimental platform to collect user interaction information that may indicate how users respond to different styles of text. The online system or the content providers can effectively target users with content items that include the style of text the users respond to based on the collected information.

Abstract: Disclosed is a preparation method of a foamed aluminum special-shaped part. The preparation method comprises the following steps: S1, pressing wax molds; S2, making a shell; S3, carrying out smelting; S4, carrying out casting; and S5, vibrating the shell. Finally, the foamed aluminum special-shaped part is obtained for a preparation process of a foamed aluminum compound casting.

Abstract: A lateral movement assistance apparatus for a vehicle includes a driving unit and a lifting device. The driving unit includes an extending sleeve, a sleeve holder, a driving shaft, a rotary plate and a driving gear. The lifting device is connected with and driven by the driving unit and includes a fixing plate, two connecting plates, a hydraulic pump, a moveable bar, a transmission unit and a wheel unit. The apparatus can be installed in a shock absorber and a wheel of a vehicle to assist lateral parking on the street and substitutes for a hoisting jack to lift the vehicle up in case of flat tire or when the car is stuck in a hole, etc.

Abstract: Hydroxamate substituted azaindoline cyanine dyes, conjugates thereof and methods of using the same are provided. The subject cyanine dyes include an azaindoline ring having a hydroxamate substituent. The dyes may further include a reactive group moieties (RGM) and/or a water soluble group. Also provided are conjugates of the subject dyes. Also provided are tandem conjugates including a fluorescent protein capable of energy transfer to the dye. Methods of detecting an analyte in a sample by contacting the sample with a detection reagent are provided. The detection agent may be a dye-conjugate that specifically binds the analyte, or may be a reactive dye which conjugates to the analyte. Also provided are compositions, e.g., kits, etc., incorporating such dyes which facilitate use in such methods.

Abstract: One or more snapshots of data stored over a period of time are maintained in a hybrid storage device comprising a magnetic disk and a solid state disk, wherein a selected snapshot stores information that allows recovery of data that is stored in the hybrid storage device at a selected point in time of the period of time. The hybrid storage device receives an input/output (I/O) command from a computational device. A category of a plurality of categories to which the I/O command belongs is determined, wherein the plurality of categories comprise writing to an unused block, writing to a used block, reading from an unused block, and reading from a used block. In response to determining the category to which the I/O command belongs, the I/O command is handled by one of the magnetic disk and the solid state disk based on the determined category.

Abstract: Hydroxamate substituted azaindoline cyanine dyes, conjugates thereof and methods of using the same are provided. The subject cyanine dyes include an azaindoline ring having a hydroxamate substituent. The dyes may further include a reactive group moieties (RGM) and/or a water soluble group. Also provided are conjugates of the subject dyes. Also provided are tandem conjugates including a fluorescent protein capable of energy transfer to the dye. Methods of detecting an analyte in a sample by contacting the sample with a detection reagent are provided. The detection agent may be a dye-conjugate that specifically binds the analyte, or may be a reactive dye which conjugates to the analyte. Also provided are compositions, e.g., kits, etc., incorporating such dyes which facilitate use in such methods.

Abstract: A sun-tracing sunshade apparatus includes a support, a first top shade member rotatably mounted on the support, a lateral shade member pivotally coupled to the first top shade member, a drive unit installed in the support and adapted for rotating the first top shade member relative to the support, a sun tracker electrically coupled with the drive unit and adapted for sensing the direction of the sun and providing a corresponding signal to the drive unit, and a push member mounted on the support and movable to touch the lateral shade member and to further bias the lateral shade member relative to the first top shade member. Thus, the first top shade member can be turned subject to the direction of sunlight to move the lateral shade member to the optimal shading position, providing excellent sun-shading effect. Further, when the lateral shade member is moved to the front side of the user, it can be lifted by the push member, avoiding hindering the user's sight.

Abstract: One or more snapshots of data stored over a period of time are maintained in a hybrid storage device comprising a magnetic disk and a solid state disk, wherein a selected snapshot stores information that allows recovery of data that is stored in the hybrid storage device at a selected point in time of the period of time. The hybrid storage device receives an input/output (I/O) command from a computational device. A category of a plurality of categories to which the I/O command belongs is determined, wherein the plurality of categories comprise writing to an unused block, writing to a used block, reading from an unused block, and reading from a used block. In response to determining the category to which the I/O command belongs, the I/O command is handled by one of the magnetic disk and the solid state disk based on the determined category.