Patents by Inventor Xing Pei

Xing Pei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8694082
    Abstract: An implantable medical device is provided for detecting transportless ventricular rhythm of a heart lacking atrial transport and comprises a housing, sensors configured to be located proximate to a heart, a sensing module to sense cardiac signals representative of a rhythm originating from the heart and a rhythm detection module. The rhythm detection module determines a change in AV association and identifies a potential ventricular complex with loss of atrial transport (VCLAT) based on the change in AV association.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: April 8, 2014
    Assignee: Pacesetter, Inc.
    Inventors: Xing Pei, Paul A. Levine
  • Publication number: 20130289645
    Abstract: An exemplary method includes performing a capture threshold assessment using a bipolar electrode configuration, deciding if capture occurred for a maximum energy value of the capture threshold assessment and, if capture did not occur, then performing a lead impedance test for the lead associated with the bipolar electrode configuration. Such a test may aim to detect an insulation defect and/or a conductor defect. Other exemplary methods, devices, systems, etc., are also disclosed.
    Type: Application
    Filed: June 27, 2013
    Publication date: October 31, 2013
    Inventors: Xing Pei, Robert E. Smith, JR., Paul A. Levine
  • Patent number: 8521279
    Abstract: An implantable cardiac stimulation device provides measurement of intrinsic heart activity metrics while sustaining pacing of the heart. The device includes a pulse generator that delivers pacing pulses to a first chamber of corresponding chambers of a heart, and a sensing circuit that senses a conducted evoked response of a second chamber of the corresponding chambers of the heart in response to the pacing pulse to provide an electrical signal representing the conducted evoked response. The device further includes a measuring circuit that measures a metric of the electrical signal to approximate a corresponding metric of an intrinsic electrical feature of the second chamber.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: August 27, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Adam F. Atherton, Xing Pei
  • Patent number: 8498706
    Abstract: An exemplary method includes performing a capture threshold assessment using a bipolar electrode configuration, deciding if capture occurred for a maximum energy value of the capture threshold assessment and, if capture did not occur, then performing a lead impedance test for the lead associated with the bipolar electrode configuration. Such a test may aim to detect an insulation defect and/or a conductor defect. Other exemplary methods, devices, systems, etc., are also disclosed.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: July 30, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Xing Pei, Robert E. Smith, Paul A. Levine
  • Patent number: 8233980
    Abstract: Techniques are provided for detecting atrial events that might be hidden due to the operation of a post-ventricular atrial blanking (PVAB) interval or other atrial channel blanking interval. In one example, candidate atrial events are identified within signals occurring during the PVAB interval. Then, a determination is made as to whether the candidate atrial event is a true atrial event based on a comparison of characteristics of the candidate atrial event with characteristics of prior known atrial events within the patient. By comparing the characteristics of the “hidden” event with the characteristics of prior known atrial events within the patient, a quick and accurate determination can be made whether the event should be counted as a P-wave. In this manner, hidden atrial arrhythmias can be detected and mode switch oscillations can be reduced or eliminated.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: July 31, 2012
    Assignee: Pacesetter, Inc.
    Inventor: Xing Pei
  • Publication number: 20120150060
    Abstract: An implantable medical device (IMD) is provided comprising inputs configured to be coupled to leads having electrodes thereon, wherein combinations of the electrodes are associated with respective active sensing vector. The IMD further comprises an impedance measurement module to collect multiple measured impedances between corresponding combinations of the electrodes. The IMD further includes an impedance derivation module to calculate a derived impedance for at least one pseudo sensing vector based on the measured impedances, wherein the pseudo sensing vector extends to or from at least one pseudo sensing site.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2012
    Applicant: PACESETTER, INC.
    Inventor: Xing Pei
  • Patent number: 8165675
    Abstract: Techniques are described for discriminating ventricular tachycardia (VT) from supraventricular tachycardia (SVT) using an implantable medical device capable of multi-site ventricular sensing. In one example, ventricular depolarization events are detected within a patient by the implantable device during a tachyarrhythmia, at both a left ventricular sensing site and a right ventricular sensing site. Ventricular event timing differences are then ascertained. The device compares the ventricular event timing differences detected during the tachyarrhythmia with predetermined supraventricular event timing differences for the patient, such as event timing differences previously detected within the patient during sinus rhythm or extrapolated from sinus rhythm values. The device then distinguishes VT from SVT based on the comparison of the event timing differences detected during the tachyarrhythmia with the predetermined supraventricular event timing differences.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: April 24, 2012
    Assignee: Pacesetter, Inc.
    Inventors: Hanbiao Wang, Bonian Dai, Xing Pei
  • Publication number: 20110230927
    Abstract: An implantable medical device is provided for detecting transportless ventricular rhythm of a heart lacking atrial transport and comprises a housing, sensors configured to be located proximate to a heart, a sensing module to sense cardiac signals representative of a rhythm originating from the heart and a rhythm detection module. The rhythm detection module determines a change in AV association and identifies a potential ventricular complex with loss of atrial transport (VCLAT) based on the change in AV association.
    Type: Application
    Filed: March 18, 2010
    Publication date: September 22, 2011
    Applicant: PACESETTER, INC.
    Inventors: Xing Pei, Paul A. Levine
  • Publication number: 20110178567
    Abstract: A method includes providing an optimal interventricular interval, determining an atrio-ventricular conduction delay for the ventricle having faster atrio-ventricular conduction, determining an interventricular conduction delay and determining an advance atrio-ventricular pacing interval, for use in pacing the ventricle having slower atrio-ventricular conduction, based at least in part on the optimal interventricular interval and the interventricular conduction delay.
    Type: Application
    Filed: March 30, 2011
    Publication date: July 21, 2011
    Applicant: PACESETTER, INC.
    Inventors: Xing Pei, Paul A. Levine
  • Publication number: 20110166617
    Abstract: An implantable cardiac stimulation device provides measurement of intrinsic heart activity metrics while sustaining pacing of the heart. The device includes a pulse generator that delivers pacing pulses to a first chamber of corresponding chambers of a heart, and a sensing circuit that senses a conducted evoked response of a second chamber of the corresponding chambers of the heart in response to the pacing pulse to provide an electrical signal representing the conducted evoked response. The device further includes a measuring circuit that measures a metric of the electrical signal to approximate a corresponding metric of an intrinsic electrical feature of the second chamber.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 7, 2011
    Applicant: PACESETTER, INC.
    Inventors: Adam F. Atherton, Xing Pei
  • Patent number: 7941217
    Abstract: An exemplary method includes providing an optimal interventricular interval, determining an atrio-ventricular conduction delay for the ventricle having faster atrio-ventricular conduction, determining an interventricular conduction delay and determining an advance atrio-ventricular pacing interval, for use in pacing the ventricle having slower atrio-ventricular conduction, based at least in part on the optimal interventricular interval and the interventricular conduction delay. Other exemplary methods, devices, systems, etc., are also disclosed.
    Type: Grant
    Filed: March 25, 2008
    Date of Patent: May 10, 2011
    Assignee: Pacesetter, Inc.
    Inventors: Xing Pei, Paul Levine
  • Publication number: 20110106194
    Abstract: Techniques are described for discriminating ventricular tachycardia (VT) from supraventricular tachycardia (SVT) using an implantable medical device capable of multi-site ventricular sensing. In one example, ventricular depolarization events are detected within a patient by the implantable device during a tachyarrhythmia, at both a left ventricular sensing site and a right ventricular sensing site. Ventricular event timing differences are then ascertained. The device compares the ventricular event timing differences detected during the tachyarrhythmia with predetermined supraventricular event timing differences for the patient, such as event timing differences previously detected within the patient during sinus rhythm or extrapolated from sinus rhythm values. The device then distinguishes VT from SVT based on the comparison of the event timing differences detected during the tachyarrhythmia with the predetermined supraventricular event timing differences.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 5, 2011
    Applicant: PACESETTER, INC.
    Inventors: Hanbiao Wang, Bonian Dai, Xing Pei
  • Patent number: 7933649
    Abstract: An implantable cardiac stimulation device provides measurement of intrinsic heart activity metrics while sustaining pacing of the heart. The device includes a pulse generator that delivers pacing pulses to a first chamber of corresponding chambers of a heart, and a sensing circuit that senses a conducted evoked response of a second chamber of the corresponding chambers of the heart in response to the pacing pulse to provide an electrical signal representing the conducted evoked response. The device further includes a measuring circuit that measures a metric of the electrical signal to approximate a corresponding metric of an intrinsic electrical feature of the second chamber.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: April 26, 2011
    Assignee: Pacesetter, Inc.
    Inventors: Adam F. Atherton, Xing Pei
  • Patent number: 7894897
    Abstract: An implantable cardiac stimulation device recognizes and accommodates fusion beats without compromising autocapture or threshold searches. The device comprises a pulse generator that provides first and second pacing pulses to a chamber of a heart. The first pacing pulses have a normal operating output level and the second pacing pulses have an output level sufficient to assure capture. The device further comprises a fusion beat predicting circuit that predicts when a next paced event of the chamber will likely be a fusion beat and a fusion beat control that causes the pulse generator to provide a second pacing pulse to the chamber in response to the fusion beat predicting circuit predicting that a next paced event will likely be a fusion beat. Thereafter, the fusion beat is confirmed.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: February 22, 2011
    Assignee: Pacesetter, Inc.
    Inventor: Xing Pei
  • Patent number: 7668593
    Abstract: A system and method for increasing the speed of individualizing amplifier gain optimization in implantable medical devices. A variable amplifier gain is initially set at a relatively high level such that the amplifier experiences at least intervals of saturation. A saturation indicator is determined which is indicative of the relative degree of saturation. The gain is then adjusted as a function of the saturation indicator. Relative larger degrees of saturation result in more aggressive gain adjustment. This increases the speed of adjustment with reduced likelihood of loss of sensing. In one implementation, one or more discrete amplifier gain adjustment steps are made in a single adjustment to effectively skip over intermediate adjustments. In another implementation, an estimate is made of a signal peak during a saturating interval. The gain is adjusted directly based on the estimated peak with appropriate sensing safety margins.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: February 23, 2010
    Assignee: Pacesetter, Inc.
    Inventors: Xing Pei, Xiaoyi Min
  • Publication number: 20090281587
    Abstract: Techniques are provided for detecting atrial events that might be hidden due to the operation of a post-ventricular atrial blanking (PVAB) interval or other atrial channel blanking interval. In one example, candidate atrial events are identified within signals occurring during the PVAB interval. Then, a determination is made as to whether the candidate atrial event is a true atrial event based on a comparison of characteristics of the candidate atrial event with characteristics of prior known atrial events within the patient. By comparing the characteristics of the “hidden” event with the characteristics of prior known atrial events within the patient, a quick and accurate determination can be made whether the event should be counted as a P-wave. In this manner, hidden atrial arrhythmias can be detected and mode switch oscillations can be reduced or eliminated.
    Type: Application
    Filed: May 7, 2008
    Publication date: November 12, 2009
    Applicant: PACESETTER, INC.
    Inventor: Xing Pei
  • Publication number: 20090281588
    Abstract: Time periods such as PVAB and PVARP are defined based on data acquired during real-time tests. For example, data may be collected during a real-time test that determines a sensing threshold or during a real-time test that determines a capture threshold. Time period information may then be derived based on correlations between the timing of far-field events and/or retrograde conduction derived from the acquired data and the timing of sensed or paced ventricular events. In some cases, the derived time period information may be used to provide timing recommendations for initial programming of an implantable device.
    Type: Application
    Filed: May 9, 2008
    Publication date: November 12, 2009
    Applicant: PACESETTER, INC.
    Inventor: Xing Pei
  • Publication number: 20090270938
    Abstract: An exemplary method includes performing a capture threshold assessment using a bipolar electrode configuration, deciding if capture occurred for a maximum energy value of the capture threshold assessment and, if capture did not occur, then performing a lead impedance test for the lead associated with the bipolar electrode configuration. Such a test may aim to detect an insulation defect and/or a conductor defect. Other exemplary methods, devices, systems, etc., are also disclosed.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 29, 2009
    Applicant: PACESETTER, INC.
    Inventors: Xing Pei, Robert E. Smith, JR., Paul A. Levine
  • Patent number: 7587243
    Abstract: A system verifies the occurrence of a cardiac event during a manual evaluation of a pacing and/or sensing parameter of an implantable cardiac stimulation device. The system comprises a template generator that generates an electrogram template standard characterizing the cardiac event, an event marker pattern generator that generates a marker pattern standard representing a desired sequence of cardiac events including the cardiac event, and a sensing circuit that senses cardiac activity to provide an evaluation electrogram signal responsive to evaluation of the pacing and/or sensing parameter. The template generator generates an evaluation electrogram and the event marker pattern generator generates an evaluation marker pattern from the evaluation electrogram signal. A cardiac event verifier verifies the occurrence of the cardiac event when the evaluation electrogram matches the electrogram template standard and the evaluation marker pattern matches the marker pattern standard.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: September 8, 2009
    Assignee: Pacesetter, Inc.
    Inventor: Xing Pei
  • Patent number: 7574259
    Abstract: An exemplary method includes performing a capture threshold assessment using a bipolar electrode configuration, deciding if capture occurred for a maximum energy value of the capture threshold assessment and, if capture did not occur, then performing a lead impedance test for the lead associated with the bipolar electrode configuration. Such a test may aim to detect an insulation defect and/or a conductor defect. Other exemplary methods, devices, systems, etc., are also disclosed.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: August 11, 2009
    Assignee: Pacesetter, Inc.
    Inventors: Xing Pei, Robert E. Smith, Paul A. Levine