Patents by Inventor Xingbin Ai

Xingbin Ai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of FGF signaling
    Patent number: 7968527
    Abstract: Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: June 28, 2011
    Assignee: Boston Biomedical Research Institute
    Inventors: Charles P. Emerson, Jr., Xingbin Ai
  • Methods for identifying modulators of hedgehog autoprocessing
    Publication number: 20070212712
    Abstract: The present invention relates to methods of screening for modulators of Hedgehog peptide autoprocessing with methods that are useful in both in vivo and high-throughput in vitro systems. The present invention also relates to reagents identified by the methods of the present invention for use in the modulation of Hh autoprocessing, especially as they relate to the treatment of illnesses and diseases that are caused, at least in part, by the misregulation of Hh autoprocessing.
    Type: Application
    Filed: December 5, 2006
    Publication date: September 13, 2007
    Inventors: Xingbin Ai, Charles Emerson, Henry Paulus
  • Inhibition of FGF signaling
    Publication number: 20050227921
    Abstract: Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.
    Type: Application
    Filed: February 11, 2005
    Publication date: October 13, 2005
    Inventors: Charles Emerson, Xingbin Ai