Abstract: Disclosed is a method for vacuum electron beam welding of twinning-induced plasticity (TWIP) steel and use thereof. The welding method according to the present disclosure includes preheating welding, tack welding, and deep penetration welding. The method according to the present disclosure can achieve welding stability, a uniform butt joint width, small splash and full arc ending, and ensure that the internal quality of a welded joint meets requirements for an ISO13919-1 grade B butt joint, and the plasticity and tensile strength of the welded joint are equivalent to those of a base metal, thereby ensuring that the welded joint has a high energy-absorbing buffering function equivalent to that of a base metal. A vehicle anti-collision beam manufactured after welding and a vehicle energy-absorbing buffer component assembled by using the anti-collision beam have the advantages of light structure, high safety protection, etc.