Patents by Inventor Xinggui Shen

Xinggui Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plasma HS levels as biomarkers for vascular disease
    Patent number: 9599602
    Abstract: Hydrogen sulfide (H2S) levels in plasma are useful in diagnosing cardiovascular disease. The ratio of H2S to NO in plasma is useful in diagnosing peripheral artery disease.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: March 21, 2017
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Christopher G. Kevil, Elvis A. Peter, Xinggui Shen
  • Measurement of biologically labile hydrogen sulfide pools
    Patent number: 9465024
    Abstract: A method to measure all relevant biologic hydrogen sulfide pools, namely free hydrogen sulfide, acid-labile sulfide, and bound sulfane sulfur, has been developed. This new method involves selective liberation, trapping and derivatization of labile hydrogen sulfide. The total labile sulfide, including the contribution of the bound sulfane sulfur pool, the acid-labile pool, and free H2S, was measured by incubating the sample with a reducing agent, TCEP (Tris(2-carboxyethyl)phosphine hydrochloride), to reduce disulfide bonds in an acid solution. This method was used to measure the three sulfide pools in blood samples from mice and from humans. This method can be used for research, environmental, and clinical diagnostic purposes in determining hydrogen sulfide bioavailability in biological or other samples.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 11, 2016
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Christopher G. Kevil, Xinggui Shen, Elvis A. Peter
  • Plasma H2S Levels as Biomarkers for Vascular Disease
    Publication number: 20150233896
    Abstract: Hydrogen sulfide (H2S) levels in plasma are useful in diagnosing cardiovascular disease. The ratio of H2S to NO in plasma is useful in diagnosing peripheral artery disease.
    Type: Application
    Filed: October 22, 2013
    Publication date: August 20, 2015
    Applicant: LSU System Office
    Inventors: Christopher KEVIL, Elvis A. PETER, Xinggui SHEN
  • Measurement of Biologically Labile Hydrogen Sulfide Pools
    Publication number: 20150056713
    Abstract: A method to measure all relevant biologic hydrogen sulfide pools, namely free hydrogen sulfide, acid-labile sulfide, and bound sulfane sulfur, has been developed. This new method involves selective liberation, trapping and derivatization of labile hydrogen sulfide. The total labile sulfide, including the contribution of the bound sulfane sulfur pool, the acid-labile pool, and free H2S, was measured by incubating the sample with a reducing agent, TCEP (Tris(2-carboxyethyl)phosphine hydrochloride), to reduce disulfide bonds in an acid solution. This method was used to measure the three sulfide pools in blood samples from mice and from humans. This method can be used for research, environmental, and clinical diagnostic purposes in determining hydrogen sulfide bioavailability in biological or other samples.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 26, 2015
    Applicant: LSU System Office
    Inventors: Christopher G. Kevil, Xinggui Shen, Elvis A. Peter