Abstract: The disclosure belongs to the technical field of medical chemistry, particularly relates to an amino lipid and their preparation method as well as an application thereof, and provides the ionizable amino lipids with a general formula as shown in Formula (I), or pharmaceutically acceptable salts thereof. The amino lipids of the disclosure can be used for delivering nucleic acids and small molecule drugs. The amino lipid compounds have two ester bonds, which obviously enhance the lysosome escape capability of the ionizable amino lipids, and are favorable for the release of delivery targets of a targeted drug or gene, etc., thus improving the delivery efficiency, and showing the good capability of delivering nucleic acids into cells in the in-vitro and in-vivo delivery study.

Abstract: Various embodiments may relate to a recycling constant-temperature ceramic floor integrated system, including a floor tile. A plurality of grooves is formed in a bottom surface of the floor tile. The bottom surface of the floor tile is connected to a base plate. A support assembly is laid between each groove and the base plate. The support assembly includes a heat conducting piece and a locating support mounted in up-and-down lapping mode. A reflecting film is disposed between the heat conducting piece and the locating support. The base plate uses a net-structure plate piece, and buckle grooves and buckle blocks are disposed at the periphery of the base plate.

Abstract: Various embodiments may relate to a recycling constant-temperature ceramic floor integrated system, including a floor tile. A plurality of grooves is formed in a bottom surface of the floor tile. The bottom surface of the floor tile is connected to a base plate. A support assembly is laid between each groove and the base plate. The support assembly includes a heat conducting piece and a locating support mounted in up-and-down lapping mode. A reflecting film is disposed between the heat conducting piece and the locating support. The base plate uses a net-structure plate piece, and buckle grooves and buckle blocks are disposed at the periphery of the base plate.