Patents by Inventor Xinglu Sun

Xinglu Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing homodimer protein mixture by using charge repulsion effect
    Patent number: 9708389
    Abstract: The invention relates to a method for preparing a homodimer protein mixture by using repulsive interaction of charges. The method comprises the step of replacing part of residues with the opposite-charged residues, so that different proteins or antibodies are unfavorable to forming heterodimers due to the repulsive interaction between like charges, while same proteins or antibodies are favorable to forming homodimers due to attractive interaction between opposite charges. The homodimer protein mixture obtained according to the method of the invention can simultaneously act on different epitopes of the same target, and simultaneously inhibit the effects of a plurality of antigens by binding to the antigens from different sources, thereby providing a new approach towards immunological diagnosis and treatment of tumors and other diseases.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: July 18, 2017
    Assignee: Suzhou Alphamab Co., Ltd.
    Inventors: Ting Xu, Tao Xu, Xiaoxiao Wang, Xinglu Sun, Ying Fan, Yan Zeng
  • METHOD FOR PREPARING HOMODIMER PROTEIN MIXTURE BY USING CHARGE REPULSION EFFECT
    Publication number: 20150274807
    Abstract: The invention relates to a method for preparing a homodimer protein mixture by using repulsive interaction of charges. The method comprises the step of replacing part of residues with the opposite-charged residues, so that different proteins or antibodies are unfavorable to forming heterodimers due to the repulsive interaction between like charges, while same proteins or antibodies are favorable to forming homodimers due to attractive interaction between opposite charges. The homodimer protein mixture obtained according to the method of the invention can simultaneously act on different epitopes of the same target, and simultaneously inhibit the effects of a plurality of antigens by binding to the antigens from different sources, thereby providing a new approach towards immunological diagnosis and treatment of tumors and other diseases.
    Type: Application
    Filed: July 25, 2013
    Publication date: October 1, 2015
    Inventors: Ting Xu, Tao Xu, Xiaoxiao Wang, Xinglu Sun, Ying Fan, Yan Zeng