Patents by Inventor Xingong Li
Xingong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140314835Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: ApplicationFiled: June 30, 2014Publication date: October 23, 2014Inventors: Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Patent number: 8802137Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: GrantFiled: March 29, 2010Date of Patent: August 12, 2014Assignee: Insmed IncorporatedInventors: Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Publication number: 20110159079Abstract: Provided is a method of preparing lipid based drug formulations with low lipid/drug ratios using coacervation techniques. Also provided are methods of delivering such lipid based drug formulations at high delivery rates, and methods of treating patients with pulmonary diseases comprising administering such lipid based drug formulations.Type: ApplicationFiled: January 3, 2011Publication date: June 30, 2011Inventors: Zhili Li, Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Patent number: 7879351Abstract: Provided is a method of preparing lipid based drug formulations with low lipid/drug ratios using coacervation techniques. Also provided are methods of delivering such lipid based drug formulations at high delivery rates, and methods of treating patients with pulmonary diseases comprising administering such lipid based drug formulations.Type: GrantFiled: April 6, 2006Date of Patent: February 1, 2011Assignee: Transave, Inc.Inventors: Zhili Li, Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Publication number: 20100260829Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: ApplicationFiled: March 29, 2010Publication date: October 14, 2010Applicant: Transave, Inc.Inventors: Lawrence Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Patent number: 7718189Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: GrantFiled: July 19, 2005Date of Patent: May 18, 2010Assignee: Transave, Inc.Inventors: Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Publication number: 20090191259Abstract: The present invention concerns a method for preparing liposomes, said method comprising the following steps: (I) mixing at least one liposome-forming lipid, a water-miscible organic solvent and aqueous medium Y to form a gel or liquid containing gel particles without sonication; and thereafter (II) (a) mixing the gel or liquid containing gel particles with aqueous medium Z1 to directly form the liposomes; (b) (i) mixing the gel or liquid containing gel particles with aqueous medium Z1 to form a curd or curdy substance; and (ii) mixing the curd or curdy substance with aqueous medium Z2 to directly form the liposomes; or (c) (i) cooling the gel or liquid containing gel particles to form a waxy substance; and (ii) mixing the waxy substance with aqueous medium Z1 to directly form the liposomes; wherein aqueous media Y, Z1 and Z2 are the same or different.Type: ApplicationFiled: January 8, 2003Publication date: July 30, 2009Applicant: TRANSAVE, INC.Inventors: Xingong Li, Tong Shangguan, Alla Polozova, Paul R. Meers, Walter R. Perkins
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Publication number: 20090105126Abstract: The present disclosure relates in part to methods of treating and prevention of pulmonary disorders in a subject in need thereof comprising administering to the subject a liposomal vancomycin compositions having low lipid to drug ratios and high concentration of vancomycin.Type: ApplicationFiled: October 23, 2008Publication date: April 23, 2009Inventors: Xingong Li, Walter R. Perkins, Anthony Scotto, Mary E. Neville
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Publication number: 20090104257Abstract: The present disclosure relates in part to liposomal vancomycin compositions having low lipid to drug ratios and high concentration of vancomycin. The present disclosure also relates in part to methods of making such compositions.Type: ApplicationFiled: October 23, 2008Publication date: April 23, 2009Inventors: Xingong Li, Walter R. Perkins
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Publication number: 20070077290Abstract: Provided is a method of preparing lipid based drug formulations with low lipid/drug ratios using coacervation techniques. Also provided are methods of delivering such lipid based drug formulations at high delivery rates, and methods of treating patients with pulmonary diseases comprising administering such lipid based drug formulations.Type: ApplicationFiled: April 6, 2006Publication date: April 5, 2007Applicant: Transave, Inc.Inventors: Zhili Li, Lawrence Boni, Brian Miller, Vladimir Malinin, Xingong Li
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Publication number: 20060073198Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: ApplicationFiled: July 19, 2005Publication date: April 6, 2006Applicant: Transave, Inc.Inventors: Lawrence Boni, Brian Miller, Vladimir Malinin, Xingong Li
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Publication number: 20060062839Abstract: A method for preparing liposomes containing at least one biologically active substance encapsulated therein under mild conditions comprises the following steps: (A) providing liposomes, wherein the liposomes are prepared by a method other than the instant method; (B) mixing the product of step (A) with a water-miscible organic solvent to form a gel or a liquid containing gel particles; and thereafter (C) (a) mixing the gel or liquid containing gel particles with aqueous medium V to directly form the liposomes containing the at least one biologically active substance encapsulated therein, (b) (i) mixing the gel or liquid containing gel particles with aqueous medium V to form a curd or curdy substance; and (ii) mixing the curd or curdy substance with aqueous medium W to directly form the liposomes containing the at least one biologically active substance encapsulated therein, or (c) (i) cooling the gel or liquid containing gel particles to form a waxy substance; and (ii) mixing the waxy substance with aqueous mType: ApplicationFiled: January 8, 2003Publication date: March 23, 2006Applicant: Elan Pharmaceuticals, Inc.Inventors: Alla Polozova, Xingong Li, Walter Perkins
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Publication number: 20060058249Abstract: A method for preparing liposomes containing at least one nucleic acid encapsulated therein comprising the following steps: (A) mixing a gel or a liquid containing gel particles with aqueous medium Z1 to directly form the liposomes containing the at least one nucleic acid encapsulated therein; (B)(i) mixing a gel or a liquid containing gel particles with aqueous medium Z1 to form a curd or curdy substance; and (ii) mixing the curd or curdy substance with aqueous medium Z2 to directly form the liposomes containing the at least one nucleic acid encapsulated therein; or (C)(i) cooling a gel or a liquid containing gel particles to form a waxy substance; and (ii) mixing the waxy substance with aqueous medium Z1 to directly form the liposomes containing the at least one nucleic acid encapsulated therein; wherein said gel or liquid containing gel particles comprises at least one liposome-forming lipid, at least one fusogenic lipid, a water-miscible organic solvent and the at least one nucleic acid; wherein an amountType: ApplicationFiled: January 8, 2003Publication date: March 16, 2006Inventors: Shangguan Tong, Xingong Li, Paul Meers, Walter Perkins
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Patent number: 6500461Abstract: This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for a number of uses in animals, particularly the administration thereto of high concentrations of therapeutically useful compound, without an undue level of side effects.Type: GrantFiled: May 19, 1999Date of Patent: December 31, 2002Assignee: The Liposome CompanyInventors: Walter Perkins, Xingong Li, Donald Hirsh, Eric Mayhew, Imran Ahmad, Shaukat Ali, Andrew Janoff
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Publication number: 20020034536Abstract: This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for a number of uses in animals, particularly the administration thereto of high concentrations of therapeutically useful compound, without an undue level of side effects.Type: ApplicationFiled: May 19, 1999Publication date: March 21, 2002Inventors: WALTER PERKINS, XINGONG LI, DONALD HIRSH, ERIC MAYHEW, IMRAN AHMAD, SHAUKAT ALI, ANDREW JANOFF