Patents by Inventor Xingru ZHOU

Xingru ZHOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11697805
    Abstract: The disclosure provides a high-fidelity polymerase with preference for gapped DNA and use thereof. The Klenow fragment (KlenDr) derived from Deinococcus radiodurans DNA polymerase I, which has the high-fidelity polymerization characteristics, is independent of 3?-5? proofreading exonuclease activity, has the preference for binding gapped DNA, and is different from the existing commercial high-fidelity polymerase. Due to the specific affinity of KlenDr to gapped DNA substrate, the 3? end of the forward primer will not be cut off, and the downstream nucleotide chain is rarely replaced.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: July 11, 2023
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Yuejin Hua, Xingru Zhou, Liangyan Wang, Xuanyi Chen
  • Publication number: 20220017880
    Abstract: The disclosure provides a high-fidelity polymerase with preference for gapped DNA and use thereof. The Klenow fragment (KlenDr) derived from Deinococcus radiodurans DNA polymerase I, which has the high-fidelity polymerization characteristics, is independent of 3?-5? proofreading exonuclease activity, has the preference for binding gapped DNA, and is different from the existing commercial high-fidelity polymerase. Due to the specific affinity of KlenDr to gapped DNA substrate, the 3? end of the forward primer will not be cut off, and the downstream nucleotide chain is rarely replaced.
    Type: Application
    Filed: April 13, 2021
    Publication date: January 20, 2022
    Inventors: Yuejin HUA, Xingru ZHOU, Liangyan WANG, Xuanyi CHEN