Abstract: A multi-area artificial fog pipe network control method and system based on a YOLOv5 algorithm are provided. The method includes: obtaining thermal sensation data of each target person based on facial skin temperature; calculating group thermal sensation data of each subarea and total group thermal sensation data of an artificial fog pipe network area; determining a total flow of fog-making water introduced into the artificial fog pipe network according to target number of people and total group thermal sensation data; controlling opening gears of atomization nozzles on the artificial fog pipe networks in subareas according to a number of the target person in each subarea, the group thermal sensation data and a micro-action type of each target person. The method can realize purposes of saving energy, reducing emission, accurately controlling the flow of the fog-making water, and the people-oriented aim and outdoor group heat comfort maximization.