Abstract: The present invention discloses a method of treating tumor using a novel pyrimidine derivative. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.

Abstract: The present invention discloses a novel pyrimidine derivative and a preparation process thereof and a use thereof in anti-tumor drugs. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.

Abstract: The present invention discloses a pyrimidine derivative containing one deuterium atom, a preparation process thereof and a use thereof. It is demonstrated through in vivo and in vitro animal experiments that the antitumor activity of the pyrimidine derivative containing one deuterium atom provided in the disclosure is significantly superior to that of the positive drug Tepotinib, and the preparation process is simple and low in cost.

Abstract: Disclosed are a dynamic non-wicking PU foam and preparation and application thereof The PU foam is prepared from polyether polyol, toluene-2,4-diisocyanate, non-wicking additive and auxiliary agent. The dynamic non-wicking additive is composed of carboxylic acids, amines and alkyl alcohols in any proportion. The auxiliary agent is composed of silicone surfactant, amine promoter, tin catalyst, pigment and water. The dynamic non-wicking PU foam has a high stability and an extremely non-wicking effect. The shoes made of the dynamic non-wicking PU foam also have extremely good dynamic non-wicking and waterproof effects, thus ensuring both comfort and stability of quality.

Abstract: Disclosed is a curved trench ball bearing, which includes an outer ring 1, a set of steel balls 2, a set of retainers 3 and an inner ring 4. The raceways of outer ring 1 and inner ring 4 are used for inlaying steel balls. At least one of them is “S”-shaped curve arc raceway end to end, the other is linear or “S”-shaped curve arc raceway. The number of the “peak” and the number of the “valley” of the curve arc raceway are equal to or an integer times of the number of steel balls. By means of this structure, a bearing can achieve the displacement of reciprocating rectilinear motion while rotating, thereby simplifying a mechanical structure of a kneading roller.

Abstract: Disclosed are a dynamic non-wicking PU foam and preparation and application thereof The PU foam is prepared from polyether polyol, toluene-2,4-diisocyanate, non-wicking additive and auxiliary agent. The dynamic non-wicking additive is composed of carboxylic acids, amines and alkyl alcohols in any proportion. The auxiliary agent is composed of silicone surfactant, amine promoter, tin catalyst, pigment and water. The dynamic non-wicking PU foam has a high stability and an extremely non-wicking effect. The shoes made of the dynamic non-wicking PU foam also have extremely good dynamic non-wicking and waterproof effects, thus ensuring both comfort and stability of quality.

Abstract: Disclosed is a curved trench ball bearing, which includes an outer ring 1, a set of steel balls 2, a set of retainers 3 and an inner ring 4. The raceways of outer ring 1 and inner ring 4 are used for inlaying steel balls. At least one of them is “S”-shaped curve arc raceway end to end, the other is linear or “S”-shaped curve arc raceway. The number of the “peak” and the number of the “valley” of the curve arc raceway are equal to or an integer times of the number of steel balls. By means of this structure, a bearing can achieve the displacement of reciprocating rectilinear motion while rotating, thereby simplifying a mechanical structure of a kneading roller.