Patents by Inventor Xingyu Lu
Xingyu Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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ECCENTRIC EXTREME HIGH-SPEED-RATE LASER HYBRID MANUFACTURING METHOD FOR ROTARY ENGINEERING COMPONENT
Publication number: 20240139813Abstract: The present disclosure relates to an eccentric extreme high-speed-rate laser hybrid manufacturing method for a rotary engineering component. By positioning an extreme high-speed-rate laser direct energy deposition machining head at a predetermined eccentric distance, the damage caused by reflected light to the machining head is effectively reduced, to prolong a service life of the machining head. Also a conventional form of a molten pool in extreme high-speed-rate laser direct energy deposition can be changed, namely from a “falling” form caused by a high-speed movement and a gravity to a “climbing” form. Thus, in extreme high-speed-rate laser direct energy deposition machining, the molten pool has a longer time to fully contact a surface of the rotary engineering component to form desirable bonding performance.Type: ApplicationFiled: February 25, 2022Publication date: May 2, 2024Applicant: Jiangsu UniversityInventors: Jinzhong LU, Xiang XU, Kaiyu LUO, Jialong DU, Xingyu BU -
Publication number: 20240104351Abstract: Implementations of this specification provide prediction methods and apparatuses for adjusting computing power. One method comprises receiving a prediction request, wherein the prediction request comprises a sample to be tested, determining a computing power coefficient allocated to the prediction request, wherein the computing power coefficient indicates a proportion of hardware computing power resources allocated to the prediction request to total hardware computing power resources needed for a neural network model to run on a computing platform, determining k sub-networks inn sub-networks of the neural network model to be used for a present time based on the computing power coefficient, where n>2, and inputting the sample to be tested to the k sub-networks to obtain a prediction result.Type: ApplicationFiled: September 25, 2023Publication date: March 28, 2024Applicant: Alipay (Hangzhou) Information Technology Co., Ltd.Inventors: Jinjie Gu, Yuze Lang, Xingyu Lu, Wenliang Zhong, Wenqi MA, Xiaodong Zeng, Guannan Zhang
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Publication number: 20240046305Abstract: A multi-booth traffic allocation scheme for multiple users if provided. In an implementation, an exposure probability of each booth and a unit traffic revenue and corresponding unit resource consumption of each candidate display object for each user are obtained. An optimization objective and a resource consumption constraint corresponding to a multi-booth traffic allocation scheme are constructed. The constructed optimization objective includes a sum value of traffic revenues for each user under the multi-booth traffic allocation scheme. The traffic revenues for each user are determined based on the exposure probability of each booth, a booth allocation scheme of candidate display objects, and the unit traffic revenue of each candidate display object. A multi-booth traffic allocation scheme when the resource consumption constraint is satisfied and the optimization objective is maximized is determined.Type: ApplicationFiled: July 28, 2023Publication date: February 8, 2024Applicant: Alipay (Hangzhou) Information Technology Co., Ltd.Inventors: Xingyu Lu, Qintong Wu, Wenliang Zhong
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Patent number: 11162139Abstract: The present invention provides a method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine, comprising the following steps: (1) DNA purification and fragmentation pretreatment: the target DNA is extracted and then broken to an average of 50 nucleotides to 10,000 nucleotides in length; (2) the repair of trace amount of DNA and the ligation thereof to the adaptor: the pre-treated DNA fragments are repaired and ligated with the sequencing adaptor required for the second-generation sequencing, (3) covalently labeling 5-methylcytosine and 5-hydroxymethylcytosine, (4) solid-phase enrichment of the labeled DNA fragments having cytosine with 5-position modification; (5) the PCR amplification of the solid-phase enriched DNA fragments, the PCR product is obtained and purified to obtain a library for the second-generation sequencing, after mapping the sequencing reads to the genome, the distribution map of the cytosine with 5-position modification in the DNA sample could be generated.Type: GrantFiled: April 26, 2017Date of Patent: November 2, 2021Assignee: Shanghai Epican Genetech Co. Ltd.Inventors: Xingyu Lu, Yanqun Song
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Publication number: 20200190581Abstract: The current disclosure provides a method that can specifically label and directly amplify 5hmC site on genomic DNA without pull-down or bisulfite treatment, which enables one to map the 5hmC site from a single DNA molecule. Aspects of the disclosure relate to a method for detecting 5-hydroxymethylcytosine (5hmC) nucleic acid bases in a nucleic acid molecule or a plurality of nucleic acid molecules, the method comprising: a. modifying the 5hmC nucleic acid base with a first functional group; b. covalently attaching a modified nucleic acid probe comprising a second functional group to the first functional group; wherein the nucleic acid probe and nucleic acid molecule are covalently linked through the first and second functional groups; c. annealing a primer to the nucleic acid probe; d. performing primer extension of the annealed primer to make a new strand; and e. detecting the new strand.Type: ApplicationFiled: January 4, 2018Publication date: June 18, 2020Inventors: Chuan HE, Xingyu LU, Lulu HU
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Patent number: 10648032Abstract: Disclosed is a high-throughput sequencing method for methylated CpG island in trace DNA, comprising the steps of: 1) treating a DNA sample with bisulfite; 2) adding the treated sample obtained in step 1) to a PCR system containing a primer A for linear amplification; 3) adding an exonuclease having single-stranded DNA cleaving activity to the PCR product in step 2) and inactivating the exonuclease after the reaction; 4) adding the product in step 3) to a PCR system containing a primer B for linear amplification; 5) adding the product in step 4) to a PCR system containing the corresponding adapter primer C and adapter primer D for amplification; and 6) purifying the PCR product in step 5) to obtain a DNA library with a specific length and carrying out the sequencing.Type: GrantFiled: May 30, 2018Date of Patent: May 12, 2020Assignee: SHANGHAI EPICAN GENETECH CO., LTD.Inventors: Xingyu Lu, Yanqun Song
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Publication number: 20180312919Abstract: Disclosed is a high-throughput sequencing method for methylated CpG island in trace DNA, comprising the steps of: 1) treating a DNA sample with bisulfite; 2) adding the treated sample obtained in step 1) to a PCR system containing a primer A for linear amplification; 3) adding an exonuclease having single-stranded DNA cleaving activity to the PCR product in step 2) and inactivating the exonuclease after the reaction; 4) adding the product in step 3) to a PCR system containing a primer B for linear amplification; 5) adding the product in step 4) to a PCR system containing the corresponding adapter primer C and adapter primer D for amplification; and 6) purifying the PCR product in step 5) to obtain a DNA library with a specific length and carrying out the sequencing.Type: ApplicationFiled: May 30, 2018Publication date: November 1, 2018Inventors: Xingyu LU, Yanqun SONG
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Publication number: 20170253924Abstract: The present invention provides a method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine, comprising the following steps: (1) DNA purification and fragmentation pretreatment: the target DNA is extracted and then broken to an average of 50 nucleotides to 10,000 nucleotides in length; (2) the repair of trace amount of DNA and the ligation thereof to the adaptor: the pre-treated DNA fragments are repaired and ligated with the sequencing adaptor required for the second-generation sequencing, (3) covalently labeling 5-methylcytosine and 5-hydroxymethylcytosine, (4) solid-phase enrichment of the labeled DNA fragments having cytosine with 5-position modification; (5) the PCR amplification of the solid-phase enriched DNA fragments, the PCR product is obtained and purified to obtain a library for the second-generation sequencing, after mapping the sequencing reads to the genome, the distribution map of the cytosine with 5-position modification in the DNA sample could be generated.Type: ApplicationFiled: April 26, 2017Publication date: September 7, 2017Inventors: Xingyu Lu, Yanqun Song
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Patent number: 9175348Abstract: A method for identifying a 5-MeC in a template nucleic is provided. The method comprises providing a template having 5-MeC, converting the 5-MeC into a further modification selected from 5-caC and 5-FC. The converted template is then sequenced, and a change in sequencing is detected that is indicative of the further modification, allowing for identifying the 5-MeC in the template nucleic acid.Type: GrantFiled: April 23, 2013Date of Patent: November 3, 2015Assignee: Pacific Biosciences of California, Inc.Inventors: Jonas Korlach, Chuan He, Tyson A. Clark, Liang Zhang, Xingyu Lu
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Publication number: 20140322707Abstract: The present invention relates to methods and compositions for detecting, evaluating, and/or mapping 5-methyl-modified and/or 5-hydroxylmethyl-modified cytosine bases within a nucleic acid molecule.Type: ApplicationFiled: April 6, 2012Publication date: October 30, 2014Applicant: The University of ChicagoInventors: Chuan He, Liang Zhang, Xingyu Lu
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Publication number: 20140004511Abstract: A method for identifying a 5-MeC in a template nucleic is provided. The method comprises providing a template having 5-MeC, converting the 5-MeC into a futher modification selected from 5-caC and 5-FC. The converted template is then sequenced, and a change in sequencing is detected that is indicative of the further modification, allowing for identifying the 5-MeC in the template nucleic acid.Type: ApplicationFiled: April 23, 2013Publication date: January 2, 2014Applicants: University of Chicago, Pacific Biosciences of California, Inc.Inventors: Jonas Korlach, Chuan He, Tyson A. Clark, Liang Zhang, Xingyu Lu