Abstract: Provided are an aromatic ring-containing biological antagonist as of general formula (I) or a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the preparation of a drug for treating diabetes, kidney diseases or hypertension.

Abstract: The present invention relates to a nitrogen-containing heterocyclic polycyclic compound, a preparation method therefor, and an application thereof. In particular, the present invention relates to a compound represented by general formula I, a preparation method for same, a pharmaceutical composition containing same, and an application of same as an Orexin receptor antagonist in the preparation of drugs related to nervous system diseases, wherein each substituent in general formula I is as defined in the description.

Abstract: Provided are a pyrazole-containing polycyclic derivative inhibitor, a preparation method therefor and an application thereof. In particular, provided are a compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and an application thereof as a P2X3 inhibitor in treatment of P2X3 receptor function disorders, particularly in treatment of neurogenic diseases, wherein the substituents in the formula (I) are the same as those in the description in definition.