Abstract: The present invention provides PD-1 monoclonal antibodies, particularly human monoclonal antibodies of PD-1, which specifically bind to PD-1 with high affinity and comprise a heavy chain and a light chain. The present invention further provides nucleic acid sequence encoding the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. Immunoconjugates, therapeutic compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating various cancers with anti-PD-1 antibodies.

Abstract: A strict reverse navigation method for optimal estimation of fine alignment is provided. The strict reverse navigation method including: establishing an adaptive control function; performing a forward navigation calculation process; performing a reverse navigation calculation process; and performing the adaptive control for a number of forward and reverse calculations. The strict reverse navigation method shortens an alignment time for the optimal estimation of fine alignment while ensuring an alignment accuracy. The strict reverse navigation method provided effectively solves a problem that an error of an initial value of filtering in an initial stage of the optimal estimation of fine alignment affects convergence speeds of subsequent stages. In the initial stage, a larger number of the forward and reverse navigation calculations are adopted to reduce an error of the initial value as much as possible and increase a convergence speed of the filtering.

Abstract: A strict reverse navigation method for optimal estimation of fine alignment is provided. The strict reverse navigation method including: establishing an adaptive control function; performing a forward navigation calculation process; performing a reverse navigation calculation process; and performing the adaptive control for a number of forward and reverse calculations. The strict reverse navigation method shortens an alignment time for the optimal estimation of fine alignment while ensuring an alignment accuracy. The strict reverse navigation method provided effectively solves a problem that an error of an initial value of filtering in an initial stage of the optimal estimation of fine alignment affects convergence speeds of subsequent stages. In the initial stage, a larger number of the forward and reverse navigation calculations are adopted to reduce an error of the initial value as much as possible and increase a convergence speed of the filtering.

Abstract: The present invention discloses a joint non-coherent integral vector tracking method based on a spatial domain, which is used for further improving the performance of a vector tracking GPS (Global Positioning System) receiver. In a new vector tracking strategy design, a phase discriminator/a frequency discriminator in a traditional vector tracking loop is discarded, and baseband signals of visible satellites in each channel are taken as an observation value after performing non-coherent integration, and EKF (abbreviation of Extended Kalman Filter) is used to estimate directly and to solve the position, the velocity, a clock error, etc. of the GPS receiver. Because of the existence of non-coherent integral calculation, when GPS satellite signals are relatively weak, a carrier to noise ratio of an observation value may be effectively improved, and the tracking sensitivity is improved.

Abstract: The present invention discloses a joint non-coherent integral vector tracking method based on a spatial domain, which is used for further improving the performance of a vector tracking GPS (Global Positioning System) receiver. In a new vector tracking strategy design, a phase discriminator/a frequency discriminator in a traditional vector tracking loop is discarded, and baseband signals of visible satellites in each channel are taken as an observation value after performing non-coherent integration, and EKE (abbreviation of Extended Kalman Filter) is used to estimate directly and to solve the position, the velocity, a clock error, etc. of the GPS receiver. Because of the existence of non-coherent integral calculation, when GPS satellite signals are relatively weak, a carrier to noise ratio of an observation value may be effectively improved, and the tracking sensitivity is improved.