Abstract: The present invention provides PD-1 monoclonal antibodies, particularly human monoclonal antibodies of PD-1, which specifically bind to PD-1 with high affinity and comprise a heavy chain and a light chain. The present invention further provides nucleic acid sequence encoding the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. Immunoconjugates, therapeutic compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating various cancers with anti-PD-1 antibodies.

Abstract: A holder for nail polish container is provided, including a receiving portion, a handle portion and an adhesion portion. The receiving portion is provided with a receiving chamber configured to receive and fix a nail polish container. The handle portion has one end connected to a bottom of the receiving portion and is configured to be gripped by fingers of a user. The adhesion portion is connected to an other end of the handle portion and configured to be adhered onto a carrier to fix the receiving portion.

Abstract: Disclosed is a mobile socket device that can be quickly fixed and disassembled, including a socket and a fixed socket. The socket has a placement surface provided with a clamp hole, and at least one power collecting surface each provided with at least one set of jacks. The fixed seat has a receiving surface provided with a buckle buckled with the clamp hole, and a mounting surface suitable for being mounted to a carrier. The mobile socket device takes into account the advantages of both a fixed socket and a mobile socket. On the one hand, the socket can be fixed in any place at any time through the fixed socket. On the other hand, the socket can be removed from the fixed seat and used as a mobile socket. In addition, the socket and the fixed seat are connected by buckle connection, facilitating mounting and disassembly.

Abstract: Disclosed is a mobile socket device that can be quickly fixed and disassembled, including a socket and a fixed socket. The socket has a placement surface provided with a clamp hole, and at least one power collecting surface each provided with at least one set of jacks. The fixed seat has a receiving surface provided with a buckle buckled with the clamp hole, and a mounting surface suitable for being mounted to a carrier. The mobile socket device takes into account the advantages of both a fixed socket and a mobile socket. On the one hand, the socket can be fixed in any place at any time through the fixed socket. On the other hand, the socket can be removed from the fixed seat and used as a mobile socket. In addition, the socket and the fixed seat are connected by buckle connection, facilitating mounting and disassembly.

Abstract: Provided is a smart matching step-down circuit, comprising an alternating current input terminal (10), a rectifier filter circuit (20), a switching circuit (30), a high voltage BUCK control step-down circuit (40), a floating zero potential control circuit (41), a voltage detection and feedback circuit (50), a PWM controller (52), a full-bridge DC/AC converter circuit (60), an alternating current output terminal (70), an output voltage detection circuit (62), and a conversion controller (80); the high voltage BUCK control step-down circuit comprises a step-down inductor (L1) and a step-down capacitor (C18); the first end of the step-down inductor is connected to the output terminal of the switching circuit; the second end of the step-down inductor is connected to the positive electrode of the step-down filter capacitor, and is used for stepping down and filtering the pulse voltage, then outputting a second current; the floating zero potential control circuit comprises a flyback diode (D11, D12); the cathode of