Patents by Inventor Xini Xhang

Xini Xhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening assay for the identification of inhibitors of macrophage migration inhibitory factor
    Publication number: 20080167228
    Abstract: The present invention encompasses assays to identify compounds that inhibit the enzymatic activity of MIF which catalyzes the tautomerization of MIF-substrates, such as D-dopachrome to DHICA. In general, the assay is conducted in vitro by adding, mixing or combining MIF and a suitable substrate in the presence or absence of a test compound, and measuring the tautomerization of the substrate. The test compounds that inhibit tautomerization in the assay are identified as MIF inhibitors.
    Type: Application
    Filed: June 14, 2007
    Publication date: July 10, 2008
    Inventors: Richard Bucala, Peter C. Ulrich, Xini Xhang, Anthony Cerami
  • Screening assay for the identification of inhibitors of macrophage migration inhibitory factor
    Publication number: 20030105014
    Abstract: The present invention encompasses assays to identify compounds that inhibit the enzymatic activity of MIF which catalyzes the tautomerization of MIF-substrates, such as D-dopachrome to DHICA. In general, the assay is conducted in vitro by adding, mixing or combining MIF and a suitable substrate in the presence or absence of a test compound, and measuring the tautomerization of the substrate. The test compounds that inhibit tautomerization in the assay are identified as MIF inhibitors.
    Type: Application
    Filed: August 23, 2002
    Publication date: June 5, 2003
    Inventors: Richard Bucala, Peter C. Ulrich, Xini Xhang, Anthony Cerami
  • Screening assay for the identification of inhibitors for macrophage migration inhibitory factor
    Patent number: 6420188
    Abstract: The present invention encompasses assays to identify compounds that inhibit the enzymatic activity of MIF which catalyzes the tautomerization of MIF-substrates, such as D-dopachrome to DHICA. In general, the assay is conducted in vitro by adding, mixing or combining MIF and a suitable substrate in the presence or absence of a test compound, and measuring the tautomerization of the substrate. The test compounds that inhibit tautomerization in the assay are identified as MIF inhibitors.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: July 16, 2002
    Assignee: The Picower Institute for Medical Research
    Inventors: Richard Bucala, Peter C. Ulrich, Xini Xhang, Anthony Cerami