Abstract: A wafer transfer cassette and an automated wafer transfer system. The wafer transfer cassette includes a wafer storage frame configured to accommodate wafers, a base, a casing, a cover and a rotary coupling mechanism. The base and the casing are fixedly connected to each other and together define a cavity in which the wafer storage frame is accommodated. The casing defines an opening through which a wafer can be placed in or taken out. The cover is pivotally coupled to the casing by means of the rotary coupling mechanism so that when the rotary coupling mechanism is rotated, the cover slides on the base and thus opens or closes the opening.