Abstract: The present invention relates to a method for the industrial preparation of ((2S)-3-([1,1?-biphenyl]-4-yl)-2-((((R)-1-aminoethyl)(hydroxy)phosphoryl)methyl)propanoyl)-L-alanine acid of following formula (E): from (S)-1-phenylethylamine via a multi-step synthesis. The present invention pertains to a method for the industrial preparation of the disodium salt of ((2S)-3-([1,1?-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl)methyl)propanoyl)-L-alanine of following formula (I): in two additional steps from the compound (E) such as defined above. The present invention also pertains to a method for diastereoisomeric enrichment of the intermediates of the method for the industrial preparation of the compound of formula (E) of the present invention.

Abstract: The present invention relates to an industrial process for the preparation of (5S,10S)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (E)-3-carboxyacrylate salt of following formula (I): wherein X is fumarate. This process comprises the following successive key steps: a kinetic resolution, formation of disulfide compound, peptide coupling, and anion exchange reaction to obtain the desired product of formula (I).

Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.

Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.

Abstract: The present invention relates to an industrial process for the preparation of (5S,10S)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (E)-3-carboxyacrylate salt of following formula (I): wherein X is fumarate. This process comprises the following successive key steps: a kinetic resolution, formation of disulfide compound, peptide coupling, and anion exchange reaction to obtain the desired product of formula (I).

Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.

Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.

Abstract: The present disclosure provides processes for the preparation of a compound of formula: which is a selective late sodium current inhibitor. The disclosure also provides compounds that are synthetic intermediates.

Abstract: The present disclosure provides processes for the preparation of a compound of formula: which is a selective late sodium current inhibitor. The disclosure also provides compounds that are synthetic intermediates.

Abstract: The present disclosure provides processes for the preparation of a compound of formula: which is a selective late sodium current inhibitor. The disclosure also provides compounds that are synthetic intermediates.

Abstract: A multifunctional humidifying and heating device with 3D simulated flame comprising a cabinet, a simulated charcoal burning area, a water vapor generator device, a light source, a water tank and a vapor guiding device; vapor channels are disposed on the vapor guiding device; the light source is disposed right below the vapor channels; the simulated charcoal burning area is disposed above the vapor channels; wherein a water inlet and a vapor outlet are disposed at an upper end of the water vapor generator; the water tank is removably connected with the water inlet of the water vapor generator; the vapor guiding device is removably connected with the vapor outlet of the water vapor generator.

Abstract: A method, system, and apparatus for tracing a user in a network are provided. The method includes activating a task for tracing a user in a network according to a tracing task message sent by an Element Management System (EMS), and sending the tracing task to an Evolved NodeB (eNodeB) through an S1 link. Therefore, the activated task for tracing user in a network can be sent through the S1 link, so as to realize tracing the user in the network in the network.

Abstract: The invention presents a reflecting assembly of a simulated fireplace which comprises a shaft and a reflecting strip arranged with a plurality of reflectors, wherein a plurality of through openings being configured on the reflecting strip along the length direction, and the shaft extending inside the through openings sequentially. With the above solutions, the reflecting assembly according to the present invention has an advantage in that the shaft could be a simple round rod without any openings on it. After the shaft goes through the through openings sequentially, each of the reflectors is simply twisted towards a certain direction so as to form the reflecting assembly. The present invention has the advantages over the prior art in that the fabrication is easier, and in that the reflecting strip could be replaced as required since it's detachable from the shaft.