Patents by Inventor Xinkai Xie

Xinkai Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CBH1A VARIANTS
    Publication number: 20150087028
    Abstract: The invention relates to recombinant expression of variant forms of M. thermophila CBH1a and homologs thereof, having improved thermoactivity, specific activity, and other desirable properties. Also provided are methods for producing ethanol and other valuable organic compounds by combining cellobiohydrolase variants with cellulosic materials.
    Type: Application
    Filed: March 12, 2013
    Publication date: March 26, 2015
    Inventors: Behnaz Behrouzian, Xinkai Xie, Kui Chan, Xiyun Zhang, Vesna Mitchell, Douglas A. Hattendorf
  • Variant LovD polypeptide
    Patent number: 8981056
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: March 17, 2015
    Assignee: The Regents of the University of California
    Inventors: Yi Tang, Xue Gao, Xinkai Xie
  • Methods and materials for making simvastatin and related compounds
    Patent number: 8951754
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: February 10, 2015
    Assignee: The Regents of the University of California
    Inventors: Yi Tang, Xinkai Xie
  • METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS
    Publication number: 20120315680
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
    Type: Application
    Filed: July 2, 2012
    Publication date: December 13, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yi Tang, Xinkai Xie
  • LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS
    Publication number: 20120190038
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.
    Type: Application
    Filed: October 8, 2010
    Publication date: July 26, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yi Tang, Xue Gao, Xinkai Xie
  • Methods and materials for making simvastatin and related compounds
    Patent number: 8211664
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: July 3, 2012
    Assignee: The Regents of the University of California
    Inventors: Yi Tang, Xinkai Xie
  • Methods and Materials for Making Simvastatin and Related Compounds
    Publication number: 20090191602
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
    Type: Application
    Filed: May 24, 2007
    Publication date: July 30, 2009
    Inventors: Yi Tang, Xinkai Xie