Abstract: Disclosed are a method and system for generating a data analysis report of a multi-parameter monitoring device. The method includes: receiving, by an application server, multi-parameter data transmitted in real time by the multi-parameter monitoring device, and storing the received multi-parameter data in a database server; the application server receiving a report generation instruction transmitted by a client, the instruction including a client identifier used for indicating a permission of the client; if the permission is a first mode permission, transmitting the multi-parameter data to the client, to allow the client to process the multi-parameter data, so as to generate a multi-parameter analysis report and a report attachment; and if the permission is a second mode permission, the application server processing the multi-parameter data to generate the multi-parameter analysis report and the report attachment, and transmitting the multi-parameter analysis report and the report attachment to the client.

Abstract: Methods for differentiating compounds that modulate the extrinsic and/or intrinsic coagulation pathways are provided. Also provided are methods for identifying a compound that modulates the extrinsic coagulation pathway. In addition, methods for determining an effective dosage of an anticoagulant in a patient are provided.

Abstract: The present invention includes animal models useful for the study of thrombosis and the use of such models in drug discovery and development. The present invention relates to the induction of thrombus formation in a murine animal model by contacting a blood vessel with a low concentration of ferric chloride (FeCl3). It is found for the first time in the present invention that the use of low ferric chloride concentrations permits thrombus formation which can be treated by known antithrombotic agents at desirable concentrations. Thus, the present invention permits the study of compounds for their possible use as antithrombotic agents under conditions which provide clinically meaningful results. Compounds discovered using the inventive animal models and methods of treatment using such compounds are also included. Gunmetal mice useful as animal thrombosis models are also included.

Abstract: The present invention includes methods of reducing the activity, such as enzymatic activity and expression, of mitogen-activated protein kinase-activated protein kinase 2. The present invention further includes methods for identifying compounds useful for reducing such activity, and methods for reducing ischemic injury by the administration of such compounds.

Abstract: This invention relates to a method for inhibiting stress-activated protein kinases (SAPKs) which comprises administering to a mammal in need thereof an effective amount of a compound which is a dual non-selective &bgr;-adrenoceptor and &agr;1-adrenoceptor antagonist.