Patents by Inventor Xinle Wu

Xinle Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptide conjugates and methods of uses
    Patent number: 11529394
    Abstract: The present disclosure provides a polypeptide conjugates comprising GLP-1 receptor agonist and a peptide linker, and pharmaceutical compositions comprising the same. Methods of using such for treating diseases are also provided.
    Type: Grant
    Filed: December 27, 2021
    Date of Patent: December 20, 2022
    Assignee: BEIJING QL BIOPHARMACEUTICAL CO., LTD.
    Inventors: Yuanyuan Zhang, Xinle Wu, Haixia Zou, Peng Zhai, Yaoguang Jin, Bo Wu, Xu Chen, Wei Guo, Xinyu Zhao, Zuobin Wang, Lingli Zeng
  • Conjugates of fusion proteins of GLP-1 and FGF21
    Patent number: 11510990
    Abstract: The present disclosure provides conjugates of polypeptides comprising GLP-1, polypeptide linker and FGF21. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.
    Type: Grant
    Filed: September 26, 2021
    Date of Patent: November 29, 2022
    Assignee: BEIJING QL BIOPHARMACEUTICAL CO., LTD.
    Inventors: Xinle Wu, Haixia Zou, Yuanyuan Zhang, Bo Wu, Wei Guo
  • POLYPEPTIDE CONJUGATES AND METHODS OF USES
    Publication number: 20220133856
    Abstract: The present disclosure provides a polypeptide conjugates comprising GLP-1 receptor agonist and a peptide linker, and pharmaceutical compositions comprising the same. Methods of using such for treating diseases are also provided.
    Type: Application
    Filed: December 27, 2021
    Publication date: May 5, 2022
    Inventors: Yuanyuan ZHANG, Xinle WU, Haixia ZOU, Peng ZHAI, Yaoguang JIN, Bo WU, Xu CHEN, Wei GUO, Xinyu ZHAO, Zuobin WANG, Lingli ZENG
  • CONJUGATES OF FUSION PROTEINS OF GLP-1 AND FGF21
    Publication number: 20220016254
    Abstract: The present disclosure provides conjugates of polypeptides comprising GLP-1, polypeptide linker and FGF21. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.
    Type: Application
    Filed: September 26, 2021
    Publication date: January 20, 2022
    Inventors: Xinle WU, Haixia ZOU, Yuanyuan ZHANG, Bo WU, Wei GUO
  • METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING CLEC-2
    Publication number: 20140227265
    Abstract: Methods of treating metabolic diseases and disorders using a Clec-2 extracellular domain are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, elevated glucose levels, elevated insulin levels and elevated triglyceride levels.
    Type: Application
    Filed: June 18, 2012
    Publication date: August 14, 2014
    Applicant: AMGEN INC.
    Inventors: Xinle Wu, Yang Li
  • METHOD OF IDENTIFYING COMPOUNDS THAT SPECIFICALLY MODULATE THE INTERACTION OF FGFR1 AND BETA KLOTHO
    Publication number: 20140189893
    Abstract: Methods of identifying compounds that specifically modulate the interaction of FGFR1 and ?-Klotho are disclosed. Identified compounds can be useful in treating metabolic diseases and disorders that involve the interaction of FGFR1 and ?-Klotho. In various embodiments the metabolic disease or disorder is diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
    Type: Application
    Filed: February 20, 2012
    Publication date: July 3, 2014
    Applicant: AMGEN INC.
    Inventors: Yang Li, Xinle Wu, Hongfei Ge, Helene Baribault, Bryan Lemon, Jackie Z. Sheng, Steven Vonderfecht, Jennifer Veronica Weiszmann, Jonitha Gardner, Grace Ki Jeong Lee
  • Chimeric polypeptides and uses thereof
    Patent number: 8324160
    Abstract: The disclosure provides nucleic acid molecules encoding chimeric polypeptides, chimeric polypeptides, pharmaceutical compositions comprising chimeric polypeptides, and methods for treating metabolic disorders such as diabetes and obesity using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: December 4, 2012
    Assignee: Amgen Inc.
    Inventors: Yang Li, Xinle Wu, Zhulun Wang
  • CHIMERIC POLYPEPTIDES AND USES THEREOF
    Publication number: 20100323954
    Abstract: The disclosure provides nucleic acid molecules encoding chimeric polypeptides, chimeric polypeptides, pharmaceutical compositions comprising chimeric polypeptides, and methods for treating metabolic disorders such as diabetes and obesity using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: June 16, 2010
    Publication date: December 23, 2010
    Applicant: AMGEN INC.
    Inventors: Yang LI, Xinle Wu, Zhulun Wang
  • Sprouty and SPRED protein biosensors
    Publication number: 20060148027
    Abstract: Sprouty/SPRED protein cysteine-rich domain (SCRD) modules comprising an iron:sulfer complex are used to sense electro/chemical signals.
    Type: Application
    Filed: January 5, 2006
    Publication date: July 6, 2006
    Inventors: Steven McKnight, Xinle Wu, Pia Vogel, Peter Alexander, Julian Peterson